FBX50_HUMAN
ID FBX50_HUMAN Reviewed; 275 AA.
AC Q6ZVX7; Q6NVV5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=F-box only protein 50;
DE AltName: Full=NCC receptor protein 1 homolog;
DE Short=NCCRP-1;
DE AltName: Full=Non-specific cytotoxic cell receptor protein 1 homolog;
GN Name=NCCRP1; Synonyms=FBXO50;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=22087255; DOI=10.1371/journal.pone.0027152;
RA Kallio H., Tolvanen M., Janis J., Pan P.W., Laurila E., Kallioniemi A.,
RA Kilpinen S., Tuominen V.J., Isola J., Valjakka J., Pastorekova S.,
RA Pastorek J., Parkkila S.;
RT "Characterization of non-specific cytotoxic cell receptor protein 1: a new
RT member of the lectin-type subfamily of F-box proteins.";
RL PLoS ONE 6:E27152-E27152(2011).
CC -!- FUNCTION: Promotes cell proliferation. {ECO:0000269|PubMed:22087255}.
CC -!- INTERACTION:
CC Q6ZVX7; Q8WTU0: DDI1; NbExp=3; IntAct=EBI-2877737, EBI-748248;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22087255}.
CC -!- TISSUE SPECIFICITY: Expressed in the esophagus, oral cavity, skin,
CC tongue and reproductive organs. {ECO:0000269|PubMed:22087255}.
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DR EMBL; AK123941; BAC85732.1; -; mRNA.
DR EMBL; AC011443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC067874; AAH67874.2; -; mRNA.
DR EMBL; BC092493; AAH92493.1; -; mRNA.
DR CCDS; CCDS12529.1; -.
DR RefSeq; NP_001001414.1; NM_001001414.1.
DR AlphaFoldDB; Q6ZVX7; -.
DR SMR; Q6ZVX7; -.
DR BioGRID; 131204; 109.
DR IntAct; Q6ZVX7; 29.
DR MINT; Q6ZVX7; -.
DR STRING; 9606.ENSP00000342137; -.
DR GlyGen; Q6ZVX7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q6ZVX7; -.
DR PhosphoSitePlus; Q6ZVX7; -.
DR BioMuta; NCCRP1; -.
DR DMDM; 74738333; -.
DR EPD; Q6ZVX7; -.
DR jPOST; Q6ZVX7; -.
DR MassIVE; Q6ZVX7; -.
DR MaxQB; Q6ZVX7; -.
DR PaxDb; Q6ZVX7; -.
DR PeptideAtlas; Q6ZVX7; -.
DR PRIDE; Q6ZVX7; -.
DR ProteomicsDB; 68447; -.
DR Antibodypedia; 45009; 73 antibodies from 17 providers.
DR DNASU; 342897; -.
DR Ensembl; ENST00000339852.5; ENSP00000342137.3; ENSG00000188505.5.
DR GeneID; 342897; -.
DR KEGG; hsa:342897; -.
DR MANE-Select; ENST00000339852.5; ENSP00000342137.3; NM_001001414.2; NP_001001414.1.
DR UCSC; uc002okq.2; human.
DR CTD; 342897; -.
DR DisGeNET; 342897; -.
DR GeneCards; NCCRP1; -.
DR HGNC; HGNC:33739; NCCRP1.
DR HPA; ENSG00000188505; Group enriched (esophagus, lymphoid tissue, skin, vagina).
DR MIM; 615901; gene.
DR neXtProt; NX_Q6ZVX7; -.
DR OpenTargets; ENSG00000188505; -.
DR PharmGKB; PA164723566; -.
DR VEuPathDB; HostDB:ENSG00000188505; -.
DR eggNOG; KOG3248; Eukaryota.
DR GeneTree; ENSGT00940000161313; -.
DR HOGENOM; CLU_068548_1_0_1; -.
DR InParanoid; Q6ZVX7; -.
DR OMA; DGDFSGW; -.
DR OrthoDB; 922544at2759; -.
DR PhylomeDB; Q6ZVX7; -.
DR TreeFam; TF320527; -.
DR PathwayCommons; Q6ZVX7; -.
DR SignaLink; Q6ZVX7; -.
DR BioGRID-ORCS; 342897; 15 hits in 1074 CRISPR screens.
DR GenomeRNAi; 342897; -.
DR Pharos; Q6ZVX7; Tbio.
DR PRO; PR:Q6ZVX7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZVX7; protein.
DR Bgee; ENSG00000188505; Expressed in lower esophagus mucosa and 80 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; IEA:GOC.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR InterPro; IPR007397; F-box-assoc_dom.
DR InterPro; IPR039752; F-box_only.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12125; PTHR12125; 1.
DR Pfam; PF04300; FBA; 1.
DR SMART; SM01198; FBA; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51114; FBA; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..275
FT /note="F-box only protein 50"
FT /id="PRO_0000326028"
FT DOMAIN 95..273
FT /note="FBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00482"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..60
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:G3X9C2"
FT MOD_RES 37
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:G3X9C2"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:G3X9C2"
SQ SEQUENCE 275 AA; 30847 MW; FB9C700E1799E50E CRC64;
MEEVREGHAL GGGMEADGPA SLQELPPSPR SPSPPPSPPP LPSPPSLPSP AAPEAPELPE
PAQPSEAHAR QLLLEEWGPL SGGLELPQRL TWKLLLLRRP LYRNLLRSPN PEGINIYEPA
PPTGPTQRPL ETLGNFRGWY IRTEKLQQNQ SWTVKQQCVD LLAEGLWEEL LDDEQPAITV
MDWFEDSRLD ACVYELHVWL LAADRRTVIA QHHVAPRTSG RGPPGRWVQV SHVFRHYGPG
VRFIHFLHKA KNRMEPGGLR RTRVTDSSVS VQLRE
