AIM6_YEAST
ID AIM6_YEAST Reviewed; 390 AA.
AC Q07716; D6VRB9; Q6B312;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Altered inheritance of mitochondria protein 6 {ECO:0000303|PubMed:19300474};
DE Flags: Precursor;
GN Name=AIM6 {ECO:0000303|PubMed:19300474};
GN OrderedLocusNames=YDL237W {ECO:0000312|SGD:S000002396};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 44.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=29897761; DOI=10.1021/acs.jproteome.8b00032;
RA He C., Jia C., Zhang Y., Xu P.;
RT "Enrichment-based proteogenomics identifies microproteins, missing
RT proteins, and novel smORFs in Saccharomyces cerevisiae.";
RL J. Proteome Res. 17:2335-2344(2018).
CC -!- DISRUPTION PHENOTYPE: Impairs respiratory growth.
CC {ECO:0000269|PubMed:19300474}.
CC -!- SIMILARITY: Belongs to the AIM6 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z74285; CAA98817.1; -; Genomic_DNA.
DR EMBL; AY692568; AAT92587.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11629.2; -; Genomic_DNA.
DR PIR; S67801; S67801.
DR RefSeq; NP_010044.2; NM_001180297.2.
DR AlphaFoldDB; Q07716; -.
DR BioGRID; 31874; 31.
DR DIP; DIP-3809N; -.
DR IntAct; Q07716; 1.
DR STRING; 4932.YDL237W; -.
DR iPTMnet; Q07716; -.
DR MaxQB; Q07716; -.
DR PaxDb; Q07716; -.
DR PRIDE; Q07716; -.
DR EnsemblFungi; YDL237W_mRNA; YDL237W; YDL237W.
DR GeneID; 851361; -.
DR KEGG; sce:YDL237W; -.
DR SGD; S000002396; AIM6.
DR VEuPathDB; FungiDB:YDL237W; -.
DR eggNOG; ENOG502QVA8; Eukaryota.
DR GeneTree; ENSGT00940000176814; -.
DR HOGENOM; CLU_031561_1_1_1; -.
DR InParanoid; Q07716; -.
DR OMA; WGCTGVE; -.
DR BioCyc; YEAST:G3O-29614-MON; -.
DR PRO; PR:Q07716; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q07716; protein.
DR GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd08577; PI-PLCc_GDPD_SF_unchar3; 1.
DR InterPro; IPR039559; AIM6_PI-PLC-like_dom.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR SUPFAM; SSF51695; SSF51695; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..390
FT /note="Altered inheritance of mitochondria protein 6"
FT /id="PRO_0000242484"
FT CONFLICT 44
FT /note="N -> D (in Ref. 1; CAA98817)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 390 AA; 44383 MW; 44A0854F903166A5 CRC64;
MLGLKGCLTI LIGYVIAVCA LFSSRGRNPS LTDWEKLKDQ KISNIDNFGL TGQHLLEFFQ
ENLPFLSFSE EKYRHKHVSL YYDVFKEYIL RRASSKKCLP VDSAIAKLNK DVNPMPVHSH
NDYWRKLPLF EGLAYGASST EADVWNIDEK ILAVGHNEAY LDPVELTLDK LYTGPLLEIL
DEVNCQDSDA DRKNGVFFNS PETSLFFYID FKSDDNELTY KLLMEQYFKS LIDSGYLTYY
DMKKDEIIWR PVTVILTGNY PTSLDILDNG NDNGYFESSQ RFAFLDAPLL SLEPKYSKLS
VAATVSFSQL MKHCGSDHWK VSLRGRMDSN EISCAKSIID GAHALKLKTR IWGAPTWPAN
LVETISRQII HDLGSDLLNL DNLFMASSLI
