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FBX8_BOVIN
ID   FBX8_BOVIN              Reviewed;         319 AA.
AC   Q5E9G6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=F-box only protein 8;
GN   Name=FBXO8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May promote guanine-nucleotide exchange on an ARF. Promotes
CC       the activation of ARF through replacement of GDP with GTP (Potential).
CC       {ECO:0000305}.
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DR   EMBL; BT020782; AAX08799.1; -; mRNA.
DR   EMBL; BT020954; AAX08971.1; -; mRNA.
DR   EMBL; BC103444; AAI03445.1; -; mRNA.
DR   RefSeq; NP_001015667.1; NM_001015667.3.
DR   RefSeq; XP_010805991.1; XM_010807689.2.
DR   AlphaFoldDB; Q5E9G6; -.
DR   SMR; Q5E9G6; -.
DR   STRING; 9913.ENSBTAP00000008831; -.
DR   PaxDb; Q5E9G6; -.
DR   PRIDE; Q5E9G6; -.
DR   Ensembl; ENSBTAT00000008831; ENSBTAP00000008831; ENSBTAG00000006715.
DR   GeneID; 538528; -.
DR   KEGG; bta:538528; -.
DR   CTD; 26269; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006715; -.
DR   VGNC; VGNC:28920; FBXO8.
DR   eggNOG; KOG0929; Eukaryota.
DR   GeneTree; ENSGT00940000158356; -.
DR   HOGENOM; CLU_057531_0_0_1; -.
DR   InParanoid; Q5E9G6; -.
DR   OMA; FFKHIHA; -.
DR   OrthoDB; 815698at2759; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000006715; Expressed in oocyte and 103 other tissues.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48425; SSF48425; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..319
FT                   /note="F-box only protein 8"
FT                   /id="PRO_0000244602"
FT   DOMAIN          68..111
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          146..276
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
SQ   SEQUENCE   319 AA;  37017 MW;  D736778E82049BB5 CRC64;
     MGQGLWRVAR NQQLQQEGYG EQGYLSREQS RRVAASNMSH TSHRKHVQGG IDIYHLLKTR
     KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD LANDELLWQG LCKSTWGHCS
     IYNKNPPLGF SFRKLYMQLD EGSLTFNANP DEGVNYFMSK GILDDSPKEI AKFIFCTRTL
     NWKKLRIYLD ERRDVLDDLV TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH
     RFCACNPDLM RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS
     EDFVGHLYDN IYLIGHVAA
 
 
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