ID   FBX8_MOUSE              Reviewed;         319 AA.
AC   Q9QZN3; Q8JZY7;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=F-box only protein 8;
GN   Name=Fbxo8; Synonyms=Fbx8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA   Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT   "A family of mammalian F-box proteins.";
RL   Curr. Biol. 9:1180-1182(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May promote guanine-nucleotide exchange on an ARF. Promotes
CC       the activation of ARF through replacement of GDP with GTP (Potential).
CC       {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: High expression in brain, heart, kidney, liver,
CC       lung, skeletal muscle, testis, and day-7 embryos.
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DR   EMBL; AF176527; AAF09136.1; -; mRNA.
DR   EMBL; AK029989; BAC26720.1; -; mRNA.
DR   EMBL; AK078111; BAC37130.1; -; mRNA.
DR   EMBL; AK147748; BAE28112.1; -; mRNA.
DR   EMBL; CH466569; EDL28608.1; -; Genomic_DNA.
DR   EMBL; CH466569; EDL28609.1; -; Genomic_DNA.
DR   EMBL; BC034854; AAH34854.1; -; mRNA.
DR   CCDS; CCDS22314.1; -.
DR   RefSeq; NP_056606.2; NM_015791.3.
DR   AlphaFoldDB; Q9QZN3; -.
DR   SMR; Q9QZN3; -.
DR   STRING; 10090.ENSMUSP00000037544; -.
DR   PhosphoSitePlus; Q9QZN3; -.
DR   PaxDb; Q9QZN3; -.
DR   PRIDE; Q9QZN3; -.
DR   ProteomicsDB; 271887; -.
DR   Antibodypedia; 1238; 233 antibodies from 24 providers.
DR   Ensembl; ENSMUST00000040218; ENSMUSP00000037544; ENSMUSG00000038206.
DR   GeneID; 50753; -.
DR   KEGG; mmu:50753; -.
DR   UCSC; uc009lsr.1; mouse.
DR   CTD; 26269; -.
DR   MGI; MGI:1354696; Fbxo8.
DR   VEuPathDB; HostDB:ENSMUSG00000038206; -.
DR   eggNOG; KOG0929; Eukaryota.
DR   GeneTree; ENSGT00940000158356; -.
DR   HOGENOM; CLU_057531_0_0_1; -.
DR   InParanoid; Q9QZN3; -.
DR   OMA; FFKHIHA; -.
DR   OrthoDB; 815698at2759; -.
DR   PhylomeDB; Q9QZN3; -.
DR   BioGRID-ORCS; 50753; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Fbxo8; mouse.
DR   PRO; PR:Q9QZN3; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9QZN3; protein.
DR   Bgee; ENSMUSG00000038206; Expressed in secondary oocyte and 251 other tissues.
DR   ExpressionAtlas; Q9QZN3; baseline and differential.
DR   Genevisible; Q9QZN3; MM.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IPI:MGI.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IPI:MGI.
DR   CDD; cd00171; Sec7; 1.
DR   Gene3D; 1.10.1000.11; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR023394; Sec7_C_sf.
DR   InterPro; IPR000904; Sec7_dom.
DR   InterPro; IPR035999; Sec7_dom_sf.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF01369; Sec7; 1.
DR   SMART; SM00222; Sec7; 1.
DR   SUPFAM; SSF48425; SSF48425; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS50190; SEC7; 1.
PE   2: Evidence at transcript level;
KW   Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..319
FT                   /note="F-box only protein 8"
FT                   /id="PRO_0000120219"
FT   DOMAIN          68..111
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          146..276
FT                   /note="SEC7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00189"
FT   CONFLICT        89
FT                   /note="T -> I (in Ref. 1; AAF09136)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   319 AA;  36970 MW;  B6A14F089FD83261 CRC64;
     MGQGLWRVAR NHHLQQEAYS ETGYLSREQS RRVASSNISH TSHRKQAQGG IDIYHLLKAR
     KSKEQEGFIN LEMLPPELSF TILSYLNATD LCLASCVWQD LANDELLWQG LCKSTWGHCS
     IYNKNPPLGF SFRKLYMQLD EGSLTFNANP EEGVSYFMSK GILDDSPKEI AKFIFCTRTL
     NWKKLRIYLD ERRDVLDDLV TLHNFRNQFL PNALREFFRH IHAPEERGEY LETLITKFSH
     RFCACNPDLM RELGLSPDAV YVLCYSLILL SIDLTSPHVK NKMSKREFIR NTRRAAQNIS
     EDFVGHLYDN IYLIGHVAA