ID   FBX9_XENTR              Reviewed;         431 AA.
AC   F6Y9J3;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=F-box only protein 9;
GN   Name=fbxo9;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC       protein) E3 ubiquitin-protein ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins and acts as a regulator of mTOR signaling. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC       complex SCF(fbxo9). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAMC01037869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01037870; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_012818287.1; XM_012962833.2.
DR   AlphaFoldDB; F6Y9J3; -.
DR   SMR; F6Y9J3; -.
DR   STRING; 8364.ENSXETP00000034875; -.
DR   PaxDb; F6Y9J3; -.
DR   Ensembl; ENSXETT00000073985; ENSXETP00000091061; ENSXETG00000015980.
DR   GeneID; 394601; -.
DR   CTD; 26268; -.
DR   Xenbase; XB-GENE-1002447; fbxo9.
DR   eggNOG; KOG2997; Eukaryota.
DR   HOGENOM; CLU_041758_0_0_1; -.
DR   InParanoid; F6Y9J3; -.
DR   OMA; DEFRENW; -.
DR   OrthoDB; 1407789at2759; -.
DR   PhylomeDB; F6Y9J3; -.
DR   TreeFam; TF324797; -.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Reactome; R-XTR-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015980; Expressed in testis and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0032006; P:regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR045118; FBXO9/FBXO48.
DR   InterPro; IPR045464; Hrt3/FBXO9_C.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   PANTHER; PTHR12874; PTHR12874; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF19270; FBO_C; 1.
DR   SUPFAM; SSF116846; SSF116846; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; TPR repeat; Ubl conjugation pathway.
FT   CHAIN           1..431
FT                   /note="F-box only protein 9"
FT                   /id="PRO_0000421762"
FT   REPEAT          81..114
FT                   /note="TPR"
FT   DOMAIN          168..219
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   431 AA;  50249 MW;  89D482B05D6676BE CRC64;
     MAEGDEDSYT DSLMSNENGR PGETNLQEEL QMFRARWMSE LTPGLSSGGL ENRPCNAAAR
     GPVGKVSETK AKQELAKEAK ARELFLKAAE EEQNGALYEA IKFYRQAMQL VPDIEFKINY
     TWSPDGDTKN FLDDANNDSK MADLLSYFQQ QLTFQQSKLC QPDIDVTQTH ISVLPMEVLM
     YIFRWVVSSD LDLRALEQLS LVCKGFYICA RDPEIWRLAC LKVWGRNCVK IVPYTTWRQM
     FLERPRVRFD GVYISKTTYI RQGEQSLDGF YRAWHQVEYY RYLRFFPDGH VMMLTTPEDP
     QTIVPRLRTK NARTDAMLLG HYRLSQDTDN QTKVFAVITN KKEEKPSDYQ KYRYFRRPQV
     QETERSFHVG LQLCSSGRHK FNKLVWIHHS CHITYKSTGE TAVTAFDIDK MYTPMFFVRV
     KSFTAVSERP L