FBXAL_DICDI
ID FBXAL_DICDI Reviewed; 1178 AA.
AC Q54N86;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=F-box/WD repeat-containing protein A-like protein;
GN ORFNames=DDB_G0285445;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC protein) E3 ubiquitin-protein ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
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DR EMBL; AAFI02000079; EAL64560.1; -; Genomic_DNA.
DR RefSeq; XP_638057.1; XM_632965.1.
DR AlphaFoldDB; Q54N86; -.
DR SMR; Q54N86; -.
DR STRING; 44689.DDB0237749; -.
DR PaxDb; Q54N86; -.
DR EnsemblProtists; EAL64560; EAL64560; DDB_G0285445.
DR GeneID; 8625103; -.
DR KEGG; ddi:DDB_G0285445; -.
DR dictyBase; DDB_G0285445; -.
DR eggNOG; KOG0274; Eukaryota.
DR HOGENOM; CLU_273369_0_0_1; -.
DR InParanoid; Q54N86; -.
DR OMA; KSWNIAT; -.
DR Reactome; R-DDI-8951664; Neddylation.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q54N86; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 3.30.530.20; -; 2.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF01852; START; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50848; START; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; Ubl conjugation pathway; WD repeat.
FT CHAIN 1..1178
FT /note="F-box/WD repeat-containing protein A-like protein"
FT /id="PRO_0000327395"
FT DOMAIN 1..208
FT /note="START"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT DOMAIN 717..763
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 886..923
FT /note="WD 1"
FT REPEAT 925..979
FT /note="WD 2"
FT REPEAT 981..1017
FT /note="WD 3"
FT REPEAT 1020..1059
FT /note="WD 4"
FT REPEAT 1062..1100
FT /note="WD 5"
FT REPEAT 1104..1141
FT /note="WD 6"
FT REPEAT 1146..1178
FT /note="WD 7"
FT REGION 223..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..837
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 135674 MW; F396A48E4CA922FC CRC64;
MQYVNGMDIV KSVYDEVKYL INYTTMPWTD LGEYEECSVQ SIENPTEEGL IFKCIGEINT
SPEIPLNVLY NANLQQIWDE LCIESKKIEQ LDSCNSVDYY SFGSPLGGAP RDFVFLRNFS
VDFENKSAWV VIRSIHHESI PSPTYMKPSG WEFLQISPNK TRITLVVQIN DLTIAPYLRI
NSVDLKRIYR NTGIQITHTL PNLIKYIKKN YKKEIENNFK KFKTPDLFNP NLNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNQQQNIK NSNSNENNNN NSDSITNSNS NENLNEKDGK
KILLPQLSEE FEFLDVDEEL YDVDKTPTFM FKETSKTVGE LEVNPVETGW NCFRKFNDYT
FYYRDYDENS LDFACSGSSF IDASAEVIFS YIFSEYSCKI DQWTCGMKTL KKLDQVTSLE
RMSFRSVLAP KDVLSAVLVK QVNYFQKGII FLGYRSLLKP STIVKTGFWY SPSAYYIIPQ
ERGCIIRYIL KFRMYLPPST YKIYPKKQIL YVISEKTRAT VEMIKYYSIN PFYLHKRKQQ
EFPHWEGIDK FSELAEIFSN IQIRHSKPSL IINSPPNSNN HENEKKRKFR DNGINSTSIS
IPSTQFCFSS GGGSGGSSSS SSSTSSSLTF SPPQQLSSPT SSSSSSTFSN DSALIDNNQQ
LDINNNNDQE YLRFSENWES YITRKPFLLL ISSGLHLRKP PKKKSPRYLE SHNLKTCSLF
DLLPYEMIQY IFTLMDATHL IRMSRTCKYF NRICLDDNIW RDLYNREFTK NSSDSLFKWS
SIEDINLGTE KKQLLDLTFD HSKKKSNNSS PLSASSSSSS PSPPLLPPPP PPIPQLPDML
LENNNKYNNR EQIQKNEHYW LNMFREKETI NRHWRAGNGK VSNLRGHKGK ISCLQMAPNQ
IFTGSKDKEF KSWNIATKQC ESTTRCGASS VISFEKDNFT KLSTDIFPYC LFMHGIIRLG
CSNGAIQHYN IATKEIEKEQ RFLYVSNGFI FMKRDIYSYE SNTVKLYDSE TEQELQMIEI
ENTKINHCKI GRFENFCMIA CTDKTVKLWD IDSNKTELVL NGHKGSVNCL DFLNDYQLIT
GSSDKTIRMW DIRNPSSAIH NIKSHSSKVK AISIYNNLRM CTGDEDSICL WNLEGSNEPN
LLTTINNLSP VECLSIDDET MLAGFSDGEV SYYDFNSK
