ID   FBXL4_BOVIN             Reviewed;         621 AA.
AC   Q0VD31;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=F-box/LRR-repeat protein 4;
DE   AltName: Full=F-box and leucine-rich repeat protein 4;
GN   Name=FBXL4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}.
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DR   EMBL; BC119862; AAI19863.1; -; mRNA.
DR   RefSeq; NP_001069527.1; NM_001076059.1.
DR   AlphaFoldDB; Q0VD31; -.
DR   SMR; Q0VD31; -.
DR   STRING; 9913.ENSBTAP00000007531; -.
DR   GeneID; 535452; -.
DR   KEGG; bta:535452; -.
DR   CTD; 26235; -.
DR   InParanoid; Q0VD31; -.
DR   OrthoDB; 672780at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF00646; F-box; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00367; LRR_CC; 7.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Leucine-rich repeat; Methylation; Mitochondrion; Nucleus;
KW   Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..621
FT                   /note="F-box/LRR-repeat protein 4"
FT                   /id="PRO_0000284976"
FT   DOMAIN          277..332
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          376..397
FT                   /note="LRR 1"
FT   REPEAT          402..421
FT                   /note="LRR 2"
FT   REPEAT          427..448
FT                   /note="LRR 3"
FT   REPEAT          452..474
FT                   /note="LRR 4"
FT   REPEAT          480..501
FT                   /note="LRR 5"
FT   REPEAT          504..524
FT                   /note="LRR 6"
FT   REPEAT          532..558
FT                   /note="LRR 7"
FT   REPEAT          559..583
FT                   /note="LRR 8"
FT   REPEAT          584..609
FT                   /note="LRR 9"
FT   MOD_RES         28
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BH70"
SQ   SEQUENCE   621 AA;  70295 MW;  B33A5B9AC3F9790C CRC64;
     MSPVFPMLTV LTMFYYMCLR RRARTATRGE IMNSHRTVES NSRTSPLNAE VVQYAKEVVD
     FSSHYGSENS MSYTMWNLAG VPNVFPSSGD FTQTAVFRTY GTWWDQCPSA PVPFKRTPAN
     FQSQDYVELA FEQQVYPTAV HVLETYHPGA VIRILACSAN PYSPGPPAEV RWETLWSEKP
     TKVNASQARQ FKPCIKQINF PTNLIRLEIN SSLLDYYTEL DAVVLHGMKD KPMLSLKTSL
     IDMNDLDEDD YEEKDDCEID NLNKKFSSTA LREGPSNGYF DKLPYELIQL ILNHLTLPDL
     CRLAQTCKLL NQHCCDPLQY IHLNLQPYWA KLNDTSLEFL QARCTLVQWL NLSWTGNRGF
     ISVAGFSRFL KVCGSELVRL ELSCSHFLNE TCLEIISEMC PNLQDLNLSS CDKLPPQAFS
     HIAKLCGLKR LVLYRTKVEQ TALLSILNFC SDLQHLSLGS CVMIEDYDVT ASMIGAKCKK
     LRTLDLWRCK NITESGIAEL ASGCPLLEEL DLGWCPTLQS STGCFARLAR QLPNLQKLFL
     TANRSVCDTD IEELASNCTR LRQLDILGTR MVSPASLRKL LESCKDLSLL DVSFCSQIDN
     RAVLELSASF PKVFIKKSFT Q