FBXL6_HUMAN
ID FBXL6_HUMAN Reviewed; 539 AA.
AC Q8N531; Q53G43; Q9H5W9; Q9UKC7;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=F-box/LRR-repeat protein 6 {ECO:0000305};
DE AltName: Full=F-box and leucine-rich repeat protein 6;
DE AltName: Full=F-box protein FBL6;
DE AltName: Full=FBL6A;
GN Name=FBXL6 {ECO:0000312|HGNC:HGNC:13603}; Synonyms=FBL6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-496.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-496.
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT SER-496.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 90-372 (ISOFORMS 1/2).
RX PubMed=10531035; DOI=10.1016/s0960-9822(00)80020-2;
RA Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M.,
RA Pagano M.;
RT "Identification of a family of human F-box proteins.";
RL Curr. Biol. 9:1177-1179(1999).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N531-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N531-2; Sequence=VSP_008498;
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DR EMBL; AK026541; BAB15499.1; -; mRNA.
DR EMBL; AK223088; BAD96808.1; -; mRNA.
DR EMBL; BC033066; AAH33066.1; -; mRNA.
DR EMBL; AF174592; AAF04513.1; -; mRNA.
DR CCDS; CCDS47942.1; -. [Q8N531-2]
DR CCDS; CCDS6422.1; -. [Q8N531-1]
DR RefSeq; NP_036294.2; NM_012162.3.
DR RefSeq; NP_078831.4; NM_024555.5.
DR AlphaFoldDB; Q8N531; -.
DR BioGRID; 117624; 60.
DR IntAct; Q8N531; 19.
DR STRING; 9606.ENSP00000330098; -.
DR iPTMnet; Q8N531; -.
DR PhosphoSitePlus; Q8N531; -.
DR BioMuta; FBXL6; -.
DR DMDM; 37537803; -.
DR EPD; Q8N531; -.
DR jPOST; Q8N531; -.
DR MassIVE; Q8N531; -.
DR MaxQB; Q8N531; -.
DR PaxDb; Q8N531; -.
DR PeptideAtlas; Q8N531; -.
DR PRIDE; Q8N531; -.
DR ProteomicsDB; 71995; -. [Q8N531-1]
DR ProteomicsDB; 71996; -. [Q8N531-2]
DR Antibodypedia; 28465; 62 antibodies from 19 providers.
DR DNASU; 26233; -.
DR Ensembl; ENST00000331890.6; ENSP00000330098.5; ENSG00000182325.11. [Q8N531-1]
DR Ensembl; ENST00000455319.6; ENSP00000403873.2; ENSG00000182325.11. [Q8N531-2]
DR Ensembl; ENST00000644788.2; ENSP00000495082.1; ENSG00000285442.2. [Q8N531-1]
DR Ensembl; ENST00000646393.1; ENSP00000496284.1; ENSG00000285442.2. [Q8N531-2]
DR GeneID; 26233; -.
DR KEGG; hsa:26233; -.
DR MANE-Select; ENST00000331890.6; ENSP00000330098.5; NM_012162.4; NP_036294.2.
DR UCSC; uc003zca.4; human. [Q8N531-1]
DR CTD; 26233; -.
DR DisGeNET; 26233; -.
DR GeneCards; FBXL6; -.
DR HGNC; HGNC:13603; FBXL6.
DR HPA; ENSG00000182325; Low tissue specificity.
DR MIM; 609076; gene.
DR neXtProt; NX_Q8N531; -.
DR OpenTargets; ENSG00000182325; -.
DR PharmGKB; PA28026; -.
DR VEuPathDB; HostDB:ENSG00000182325; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00390000009358; -.
DR HOGENOM; CLU_023545_1_1_1; -.
DR InParanoid; Q8N531; -.
DR OrthoDB; 1606135at2759; -.
DR PhylomeDB; Q8N531; -.
DR TreeFam; TF324422; -.
DR PathwayCommons; Q8N531; -.
DR SignaLink; Q8N531; -.
DR BioGRID-ORCS; 26233; 23 hits in 1120 CRISPR screens.
DR ChiTaRS; FBXL6; human.
DR GenomeRNAi; 26233; -.
DR Pharos; Q8N531; Tdark.
DR PRO; PR:Q8N531; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8N531; protein.
DR Bgee; ENSG00000182325; Expressed in mucosa of transverse colon and 94 other tissues.
DR Genevisible; Q8N531; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; TAS:ProtInc.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; TAS:ProtInc.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF13516; LRR_6; 1.
DR SMART; SM00367; LRR_CC; 3.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..539
FT /note="F-box/LRR-repeat protein 6"
FT /id="PRO_0000119847"
FT DOMAIN 10..162
FT /note="F-box"
FT REPEAT 177..203
FT /note="LRR 1"
FT REPEAT 204..229
FT /note="LRR 2"
FT REPEAT 230..255
FT /note="LRR 3"
FT REPEAT 281..307
FT /note="LRR 4"
FT REPEAT 312..337
FT /note="LRR 5"
FT REPEAT 341..365
FT /note="LRR 6"
FT REPEAT 368..393
FT /note="LRR 7"
FT REPEAT 394..419
FT /note="LRR 8"
FT REPEAT 423..449
FT /note="LRR 9"
FT REPEAT 453..481
FT /note="LRR 10"
FT REPEAT 482..507
FT /note="LRR 11"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 49..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 208..213
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.2"
FT /id="VSP_008498"
FT VARIANT 496
FT /note="G -> S (in dbSNP:rs114720164)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_085739"
SQ SEQUENCE 539 AA; 58558 MW; 8153184415203FB2 CRC64;
MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS EPGPARPRAQ
RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT PTPEEGPDAG WGDRIPLEIL
VQIFGLLVAA DGPMPFLGRA ARVCRRWQEA ASQPALWHTV TLSSPLVGRP AKGGVKAEKK
LLASLEWLMP NRFSQLQRLT LIHWKSQVHP VLKLVGECCP RLTFLKLSGC HGVTADALVM
LAKACCQLHS LDLQHSMVES TAVVSFLEEA GSRMRKLWLT YSSQTTAILG ALLGSCCPQL
QVLEVSTGIN RNSIPLQLPV EALQKGCPQL QVLRLLNLMW LPKPPGRGVA PGPGFPSLEE
LCLASSTCNF VSNEVLGRLL HGSPNLRLLD LRGCARITPA GLQDLPCREL EQLHLGLYGT
SDRLTLAKEG SPFLTQKWCH TLRELDLSGQ GFSEKDLEQA LAAFLSTPGG SHPALCSLNL
RGTRVTPSTV SSVISGCPGL LYLNLESCRC LPRGLKRAYR GLEEVQWCLE QLLTSPSPS
