FBXL6_MOUSE
ID FBXL6_MOUSE Reviewed; 535 AA.
AC Q9QXW0; Q9JJD7;
DT 03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2003, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=F-box/LRR-repeat protein 6;
DE AltName: Full=F-box and leucine-rich repeat protein 6;
DE AltName: Full=F-box protein FBL6;
GN Name=Fbxl6; Synonyms=Fbl6; ORFNames=MNCb-1275;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT "A family of mammalian F-box proteins.";
RL Curr. Biol. 9:1180-1182(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9QXW0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9QXW0-2; Sequence=VSP_008500;
CC Name=3;
CC IsoId=Q9QXW0-3; Sequence=VSP_008499;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF22828.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF176522; AAF22828.1; ALT_FRAME; mRNA.
DR EMBL; AB041571; BAA95055.1; -; mRNA.
DR EMBL; BC054377; AAH54377.1; -; mRNA.
DR CCDS; CCDS49653.1; -. [Q9QXW0-1]
DR RefSeq; NP_038937.2; NM_013909.2. [Q9QXW0-1]
DR AlphaFoldDB; Q9QXW0; -.
DR SMR; Q9QXW0; -.
DR STRING; 10090.ENSMUSP00000023219; -.
DR iPTMnet; Q9QXW0; -.
DR PhosphoSitePlus; Q9QXW0; -.
DR EPD; Q9QXW0; -.
DR MaxQB; Q9QXW0; -.
DR PaxDb; Q9QXW0; -.
DR PeptideAtlas; Q9QXW0; -.
DR PRIDE; Q9QXW0; -.
DR ProteomicsDB; 267357; -. [Q9QXW0-1]
DR ProteomicsDB; 267358; -. [Q9QXW0-2]
DR ProteomicsDB; 267359; -. [Q9QXW0-3]
DR Antibodypedia; 28465; 62 antibodies from 19 providers.
DR DNASU; 30840; -.
DR Ensembl; ENSMUST00000023219; ENSMUSP00000023219; ENSMUSG00000022559. [Q9QXW0-1]
DR GeneID; 30840; -.
DR KEGG; mmu:30840; -.
DR UCSC; uc007wkp.2; mouse. [Q9QXW0-1]
DR UCSC; uc007wks.2; mouse. [Q9QXW0-3]
DR CTD; 26233; -.
DR MGI; MGI:1354705; Fbxl6.
DR VEuPathDB; HostDB:ENSMUSG00000022559; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00390000009358; -.
DR HOGENOM; CLU_023545_1_1_1; -.
DR InParanoid; Q9QXW0; -.
DR OMA; INCFLAK; -.
DR OrthoDB; 1606135at2759; -.
DR PhylomeDB; Q9QXW0; -.
DR TreeFam; TF324422; -.
DR BioGRID-ORCS; 30840; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Fbxl6; mouse.
DR PRO; PR:Q9QXW0; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9QXW0; protein.
DR Bgee; ENSMUSG00000022559; Expressed in granulocyte and 168 other tissues.
DR Genevisible; Q9QXW0; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00367; LRR_CC; 3.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Leucine-rich repeat; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..535
FT /note="F-box/LRR-repeat protein 6"
FT /id="PRO_0000119848"
FT DOMAIN 54..106
FT /note="F-box"
FT REPEAT 169..195
FT /note="LRR 1"
FT REPEAT 196..221
FT /note="LRR 2"
FT REPEAT 222..247
FT /note="LRR 3"
FT REPEAT 273..299
FT /note="LRR 4"
FT REPEAT 304..329
FT /note="LRR 5"
FT REPEAT 330..357
FT /note="LRR 6"
FT REPEAT 360..385
FT /note="LRR 7"
FT REPEAT 386..411
FT /note="LRR 8"
FT REPEAT 415..441
FT /note="LRR 9"
FT REPEAT 474..499
FT /note="LRR 10"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..231
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_008499"
FT VAR_SEQ 187..238
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_008500"
SQ SEQUENCE 535 AA; 59268 MW; AEF85C18AD3A80FC CRC64;
MAPVASRRVR RRVRSSKRPD ARGRSAEDWW WDRLAPRGSG YHLLQADSML LVLPDLEPPR
ARAHRRARRR APRSLARGPT AVAKPRTKPR PEPSLDQGLD SGWGDRIPLE VLVHIFGLLV
AAHGPMPFLG RAARVCRHWH EATSHPSLWH TVTLSPSLVG RAGKGNLKGE KKLLACLEWL
VPNRFSQLQS LTLIHWKSQV HSVLELVSKF CPRLTFLKLS DCHTVTAETL VMLARACCQL
HSLDLHHSMV ESTAVVSFLE EAGSRMRKLW LTYSSQTTAI LGALLDNCCP QLQVLQVSTG
MNCNNTPLQL PVEALQKGCP QLQVLRLLNL IWLPKPCGRG VPQGPGFPSL EELCLAGSTC
NFVSNEVLGR LLHRSPKLRM LDLRGCARVT PSGLCHLPCQ ELEQLYLGLY GISDGLTLAK
DGSPLLTRKW YHTLRELDFS GQGFSEKDLE QALAVFSGTP GGLHPALCSL NLRGTRVTPS
TVSSVISGCP GLLYLNLESC RCLPRGLKRV YRGLEEVQWC LEQLLTSPPS AKEPT
