ID   FBXL8_BOVIN             Reviewed;         374 AA.
AC   Q08DG4;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=F-box/LRR-repeat protein 8;
DE   AltName: Full=F-box and leucine-rich repeat protein 8;
GN   Name=FBXL8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- CAUTION: While the gene symbol and protein names are indicative of the
CC       presence of LRR repeats, such repeats are not present in this protein.
CC       {ECO:0000305}.
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DR   EMBL; BC123762; AAI23763.1; -; mRNA.
DR   RefSeq; NP_001070405.1; NM_001076937.1.
DR   AlphaFoldDB; Q08DG4; -.
DR   SMR; Q08DG4; -.
DR   STRING; 9913.ENSBTAP00000032274; -.
DR   PaxDb; Q08DG4; -.
DR   GeneID; 614765; -.
DR   KEGG; bta:614765; -.
DR   CTD; 55336; -.
DR   eggNOG; ENOG502QU59; Eukaryota.
DR   InParanoid; Q08DG4; -.
DR   OrthoDB; 1216869at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR039592; Fbxl8.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR16134:SF0; PTHR16134:SF0; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..374
FT                   /note="F-box/LRR-repeat protein 8"
FT                   /id="PRO_0000274488"
FT   DOMAIN          2..48
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   374 AA;  40594 MW;  7E798674990C6FE1 CRC64;
     MAEPGEQLPE EVLALIFRHL PLPDRAAAAR VCRAWAAAAT CSAVWHDTSI SCDCELEGML
     PPYLSACLDH VQNLWLEFEP SRKSSRRAAT DLLTALTGRT PGLRGLCLEC RGEKPLFDAG
     RDVLDAVHAL CGAASALRHL DLRRLPFSLD DALVLQVAHG CPELRSLFLD NRTLVGSVGP
     GSVLELLEAC PCLRALGLHL ASLSRTALEA LAAPERAPFE LLALRCACPE DARAPPLPDE
     AWAALSLRHP GLQVELELEP VLPAESVTRV LQPAVPVATL RLSLSGDTVG PVRFAARHYA
     ATLRALEVRA AASAELDAAL EELAARCARL REVHCFCVVR PSVLHAFRAR CPRLRSYTLK
     VTREPHPWRP TLVA