FBXL8_HUMAN
ID FBXL8_HUMAN Reviewed; 374 AA.
AC Q96CD0; Q9NUM0;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=F-box/LRR-repeat protein 8;
DE AltName: Full=F-box and leucine-rich repeat protein 8;
DE AltName: Full=F-box protein FBL8;
GN Name=FBXL8; Synonyms=FBL8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96CD0; P13196: ALAS1; NbExp=3; IntAct=EBI-2321097, EBI-3905054;
CC Q96CD0; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-2321097, EBI-79165;
CC Q96CD0; P63208: SKP1; NbExp=14; IntAct=EBI-2321097, EBI-307486;
CC -!- CAUTION: While the gene symbol and protein names are indicative of the
CC presence of LRR repeats, such repeats are not present in this protein.
CC {ECO:0000305}.
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DR EMBL; AK002140; BAA92103.1; -; mRNA.
DR EMBL; BC014414; AAH14414.1; -; mRNA.
DR CCDS; CCDS10831.1; -.
DR RefSeq; NP_060848.2; NM_018378.2.
DR AlphaFoldDB; Q96CD0; -.
DR SMR; Q96CD0; -.
DR BioGRID; 120617; 10.
DR IntAct; Q96CD0; 8.
DR STRING; 9606.ENSP00000258200; -.
DR BioMuta; FBXL8; -.
DR DMDM; 38257737; -.
DR EPD; Q96CD0; -.
DR jPOST; Q96CD0; -.
DR MassIVE; Q96CD0; -.
DR MaxQB; Q96CD0; -.
DR PaxDb; Q96CD0; -.
DR PeptideAtlas; Q96CD0; -.
DR PRIDE; Q96CD0; -.
DR ProteomicsDB; 76179; -.
DR Antibodypedia; 29422; 154 antibodies from 21 providers.
DR DNASU; 55336; -.
DR Ensembl; ENST00000258200.8; ENSP00000258200.3; ENSG00000135722.9.
DR Ensembl; ENST00000519917.5; ENSP00000430490.1; ENSG00000135722.9.
DR GeneID; 55336; -.
DR KEGG; hsa:55336; -.
DR MANE-Select; ENST00000258200.8; ENSP00000258200.3; NM_018378.3; NP_060848.2.
DR UCSC; uc002erk.2; human.
DR CTD; 55336; -.
DR DisGeNET; 55336; -.
DR GeneCards; FBXL8; -.
DR HGNC; HGNC:17875; FBXL8.
DR HPA; ENSG00000135722; Low tissue specificity.
DR MIM; 609077; gene.
DR neXtProt; NX_Q96CD0; -.
DR OpenTargets; ENSG00000135722; -.
DR PharmGKB; PA28028; -.
DR VEuPathDB; HostDB:ENSG00000135722; -.
DR eggNOG; ENOG502QU59; Eukaryota.
DR GeneTree; ENSGT00420000029943; -.
DR HOGENOM; CLU_062031_1_0_1; -.
DR InParanoid; Q96CD0; -.
DR OMA; KREPHPW; -.
DR OrthoDB; 1216869at2759; -.
DR PhylomeDB; Q96CD0; -.
DR TreeFam; TF321665; -.
DR PathwayCommons; Q96CD0; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q96CD0; -.
DR BioGRID-ORCS; 55336; 8 hits in 1111 CRISPR screens.
DR GenomeRNAi; 55336; -.
DR Pharos; Q96CD0; Tdark.
DR PRO; PR:Q96CD0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q96CD0; protein.
DR Bgee; ENSG00000135722; Expressed in body of pancreas and 95 other tissues.
DR ExpressionAtlas; Q96CD0; baseline and differential.
DR Genevisible; Q96CD0; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039592; Fbxl8.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR16134:SF0; PTHR16134:SF0; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..374
FT /note="F-box/LRR-repeat protein 8"
FT /id="PRO_0000119850"
FT DOMAIN 2..48
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT CONFLICT 135
FT /note="S -> N (in Ref. 1; BAA92103)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 374 AA; 40516 MW; 7B91444E31E95931 CRC64;
MAEPGEGLPE EVLALIFRHL SLRDRAAAAR VCRAWAAAAT CSAVWHDTKI SCECELEGML
PPYLSACLDH IHNLRLEFEP SRKPSRRAAI ELLMVLAGRA PGLRGLRLEC RGEKPLFDAG
RDVLEAVHAV CGAASQLRHL DLRRLSFTLD DALVLQAARS CPELHSLFLD NSTLVGSVGP
GSVLELLEAC PRLRALGLHL ASLSHAILEA LAAPDRAPFA LLALRCACPE DARASPLPNE
AWVALRRRHP GLAVELELEP ALPAESVTRV LQPAVPVAAL RLNLSGDTVG PVRFAAHHYA
ATLCALEVRA AASAELNAAL EELAARCAAL REVHCFCVVS HSVLDAFRAH CPRLRTYTLK
LTREPHPWRP TLVA
