FBXL8_MOUSE
ID FBXL8_MOUSE Reviewed; 374 AA.
AC Q8CIG9; Q9QZN7;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=F-box/LRR-repeat protein 8;
DE AltName: Full=F-box and leucine-rich repeat protein 8;
DE AltName: Full=F-box protein FBL8;
GN Name=Fbxl8; Synonyms=Fbl8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SKP1, AND TISSUE SPECIFICITY.
RX PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT "A family of mammalian F-box proteins.";
RL Curr. Biol. 9:1180-1182(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed during embryogenesis and in adult
CC tissues. {ECO:0000269|PubMed:10531037}.
CC -!- CAUTION: While the gene symbol and protein names are indicative of the
CC presence of LRR repeats, such repeats are not present in this protein.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF176523; AAF09132.1; -; mRNA.
DR EMBL; BC023902; AAH23902.1; -; mRNA.
DR CCDS; CCDS22595.1; -.
DR RefSeq; NP_056636.2; NM_015821.2.
DR AlphaFoldDB; Q8CIG9; -.
DR SMR; Q8CIG9; -.
DR BioGRID; 206120; 1.
DR STRING; 10090.ENSMUSP00000038638; -.
DR EPD; Q8CIG9; -.
DR MaxQB; Q8CIG9; -.
DR PaxDb; Q8CIG9; -.
DR PRIDE; Q8CIG9; -.
DR ProteomicsDB; 267360; -.
DR DNASU; 50788; -.
DR Ensembl; ENSMUST00000036221; ENSMUSP00000038638; ENSMUSG00000033313.
DR GeneID; 50788; -.
DR KEGG; mmu:50788; -.
DR UCSC; uc009nbz.2; mouse.
DR CTD; 55336; -.
DR MGI; MGI:1354697; Fbxl8.
DR VEuPathDB; HostDB:ENSMUSG00000033313; -.
DR eggNOG; ENOG502QU59; Eukaryota.
DR GeneTree; ENSGT00420000029943; -.
DR HOGENOM; CLU_062031_1_0_1; -.
DR InParanoid; Q8CIG9; -.
DR OMA; KREPHPW; -.
DR OrthoDB; 1216869at2759; -.
DR PhylomeDB; Q8CIG9; -.
DR TreeFam; TF321665; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 50788; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Fbxl8; mouse.
DR PRO; PR:Q8CIG9; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8CIG9; protein.
DR Bgee; ENSMUSG00000033313; Expressed in granulocyte and 72 other tissues.
DR ExpressionAtlas; Q8CIG9; baseline and differential.
DR Genevisible; Q8CIG9; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IBA:GO_Central.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039592; Fbxl8.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR16134:SF0; PTHR16134:SF0; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..374
FT /note="F-box/LRR-repeat protein 8"
FT /id="PRO_0000119851"
FT DOMAIN 2..48
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT CONFLICT 288
FT /note="T -> N (in Ref. 1; AAF09132)"
FT /evidence="ECO:0000305"
FT CONFLICT 300
FT /note="A -> D (in Ref. 1; AAF09132)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 374 AA; 41145 MW; CBDFBF5B6656BEE4 CRC64;
MGELVDNLPE EVLALIFRDL PLRDLAVATR VCRAWAAAAA NSTVWSDKSI SCDCELEDLL
PPYLSSCLDH IHNLRLEYEP SKKPSRGTAT ELLTALASRA PRLRGLRLEC RGEKPLFDAG
QDILGAVHAV CGAAHQLRHL DLRHLPYTLD DTLVLKAAAG CPELRSLFLD NHALVNSVQP
TSVLKLLEAC PHLRALGLHL ASMSRAALEL LAAPHRSPFA LLALRCACPE DARASPLPDE
AWATLSCRHP GLEVELELEP VLPDEAVTRI LQPAVPVAVL RLNLSGDTVG PVRFATRHYA
ETLRALEVRA SASPELHTAL EELAARCAGL REIHCFCVVR PSVLDAFRAH CPRLRSYTLK
LKREPHPWRP TLVR
