ID   FBXW2_BOVIN             Reviewed;         454 AA.
AC   Q58D00; Q58DP3;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=F-box/WD repeat-containing protein 2;
DE   AltName: Full=F-box and WD-40 domain-containing protein 2;
GN   Name=FBXW2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; BT021554; AAX46401.1; -; mRNA.
DR   EMBL; BT021797; AAX46644.1; -; mRNA.
DR   EMBL; BC120224; AAI20225.1; -; mRNA.
DR   RefSeq; NP_001070442.1; NM_001076974.1.
DR   AlphaFoldDB; Q58D00; -.
DR   SMR; Q58D00; -.
DR   STRING; 9913.ENSBTAP00000000956; -.
DR   PaxDb; Q58D00; -.
DR   Ensembl; ENSBTAT00000000956; ENSBTAP00000000956; ENSBTAG00000000712.
DR   Ensembl; ENSBTAT00000085937; ENSBTAP00000067173; ENSBTAG00000000712.
DR   GeneID; 767863; -.
DR   KEGG; bta:767863; -.
DR   CTD; 26190; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000712; -.
DR   VGNC; VGNC:28923; FBXW2.
DR   eggNOG; KOG0274; Eukaryota.
DR   GeneTree; ENSGT00930000151016; -.
DR   HOGENOM; CLU_041488_0_0_1; -.
DR   InParanoid; Q58D00; -.
DR   OMA; ASHWKGI; -.
DR   OrthoDB; 1121375at2759; -.
DR   TreeFam; TF333134; -.
DR   Reactome; R-BTA-8951664; Neddylation.
DR   Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000000712; Expressed in ruminant reticulum and 106 other tissues.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR042627; FBXW2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR44436; PTHR44436; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Reference proteome; Repeat; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN           1..454
FT                   /note="F-box/WD repeat-containing protein 2"
FT                   /id="PRO_0000259958"
FT   DOMAIN          54..101
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          146..183
FT                   /note="WD 1"
FT   REPEAT          185..221
FT                   /note="WD 2"
FT   REPEAT          224..265
FT                   /note="WD 3"
FT   REPEAT          276..314
FT                   /note="WD 4"
FT   MOD_RES         298
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UKT8"
SQ   SEQUENCE   454 AA;  51467 MW;  5E9BC766ABD2362A CRC64;
     MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL
     PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKSLGWQID DSVQDALHWK
     KVYLKAILRM KQLEDHEAFE TSSLIGHSAR VYALYYKDGL LCTGSDDLSA KLWDVSTGQC
     VYGIQTHTCA AVKFDEQKLV TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYNDELDI
     LVSGSADFTV KVWALSAGTC LNTLTGHTEW VTKVVLQKCK VKSLLHSPGD YILLSADKYE
     IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW DFASYDILRV
     IKTPEIANLA LLGFGDIFAL LFDNRYLYIL DLRTESLISR WPLPEYRKSK RGSSFLAGEA
     SWLNGLDGHN DTGLVFATSM PDHSIHLVLW KEHG