ID   FBXW2_RAT               Reviewed;         454 AA.
AC   B2RZ17;
DT   09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=F-box/WD repeat-containing protein 2;
DE   AltName: Full=F-box and WD-40 domain-containing protein 2 {ECO:0000312|EMBL:AAI66990.1};
DE   AltName: Full=Protein MD6 {ECO:0000250|UniProtKB:Q9UKT8};
GN   Name=Fbxw2 {ECO:0000312|RGD:1310460};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:EDL93165.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAI66990.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway {ECO:0000312|EMBL:AAI66990.1};
RC   TISSUE=Kidney {ECO:0000312|EMBL:AAI66990.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex.
CC       {ECO:0000250|UniProtKB:Q9UKT8}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; CH474001; EDL93165.1; -; Genomic_DNA.
DR   EMBL; CH474001; EDL93166.1; -; Genomic_DNA.
DR   EMBL; BC166990; AAI66990.1; -; mRNA.
DR   RefSeq; NP_001101305.1; NM_001107835.2.
DR   RefSeq; XP_006234039.1; XM_006233977.3.
DR   RefSeq; XP_008759973.1; XM_008761751.2.
DR   RefSeq; XP_008759974.1; XM_008761752.2.
DR   AlphaFoldDB; B2RZ17; -.
DR   SMR; B2RZ17; -.
DR   STRING; 10116.ENSRNOP00000025399; -.
DR   iPTMnet; B2RZ17; -.
DR   PhosphoSitePlus; B2RZ17; -.
DR   PaxDb; B2RZ17; -.
DR   PeptideAtlas; B2RZ17; -.
DR   GeneID; 311881; -.
DR   KEGG; rno:311881; -.
DR   UCSC; RGD:1310460; rat.
DR   CTD; 26190; -.
DR   RGD; 1310460; Fbxw2.
DR   VEuPathDB; HostDB:ENSRNOG00000018687; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   HOGENOM; CLU_041488_0_0_1; -.
DR   InParanoid; B2RZ17; -.
DR   OMA; ASHWKGI; -.
DR   OrthoDB; 1121375at2759; -.
DR   PhylomeDB; B2RZ17; -.
DR   TreeFam; TF333134; -.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:B2RZ17; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Proteomes; UP000234681; Chromosome 3.
DR   Bgee; ENSRNOG00000018687; Expressed in lung and 19 other tissues.
DR   Genevisible; B2RZ17; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR042627; FBXW2.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR44436; PTHR44436; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Reference proteome; Repeat; Ubl conjugation pathway;
KW   WD repeat.
FT   CHAIN           1..454
FT                   /note="F-box/WD repeat-containing protein 2"
FT                   /id="PRO_0000391377"
FT   DOMAIN          54..101
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          146..183
FT                   /note="WD 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          185..221
FT                   /note="WD 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          224..265
FT                   /note="WD 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          276..314
FT                   /note="WD 4"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         298
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UKT8"
SQ   SEQUENCE   454 AA;  51408 MW;  FFF540F2CC34453A CRC64;
     MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET LLKRDFLKLL
     PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT ACKNLGWQID DSVQDALHWK
     KVYLKAILRM KQLEDHEAFE TSSLIGHSAR VYALYYKDGL LCTGSDDLSA KLWDVSTGQC
     VYGIQTHTCA AVKFDEQKLV TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI
     LVSGSADFAV KVWALSAGTC LNTLTGHTEW VTKVVLQQCK VKSLLHSPGD YILLSADKYE
     IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW DFASYDILRV
     IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR WPLPEYRKSK RGSSFLAGEA
     SWLNGLDGHN DTGLVFATSM PDHSIHLVLW KEHG