ID   FBXW9_BOVIN             Reviewed;         458 AA.
AC   Q2T9T9;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=F-box/WD repeat-containing protein 9;
DE   AltName: Full=F-box and WD-40 domain-containing protein 9;
GN   Name=FBXW9;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; BC111274; AAI11275.1; -; mRNA.
DR   RefSeq; NP_001033240.1; NM_001038151.2.
DR   AlphaFoldDB; Q2T9T9; -.
DR   SMR; Q2T9T9; -.
DR   STRING; 9913.ENSBTAP00000027872; -.
DR   PaxDb; Q2T9T9; -.
DR   PRIDE; Q2T9T9; -.
DR   GeneID; 532538; -.
DR   KEGG; bta:532538; -.
DR   CTD; 84261; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   InParanoid; Q2T9T9; -.
DR   OrthoDB; 1109214at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Reference proteome; Repeat;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..458
FT                   /note="F-box/WD repeat-containing protein 9"
FT                   /id="PRO_0000249466"
FT   DOMAIN          76..123
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          171..210
FT                   /note="WD 1"
FT   REPEAT          224..261
FT                   /note="WD 2"
FT   REPEAT          264..301
FT                   /note="WD 3"
FT   REPEAT          305..342
FT                   /note="WD 4"
FT   REPEAT          344..381
FT                   /note="WD 5"
FT   REPEAT          387..424
FT                   /note="WD 6"
FT   REPEAT          427..458
FT                   /note="WD 7"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5XUX1"
FT   MOD_RES         18
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5XUX1"
FT   MOD_RES         59
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5XUX1"
SQ   SEQUENCE   458 AA;  50654 MW;  8BAB059AE827994D CRC64;
     MELPPGPRDD PHAWDDDSDP ELEPDTDAQA EAYVARLLSP PKLGLAPPRA PPLPAPTVSF
     GSLEPRAASK GPTVAVPGLL SLPPELLLEI CAYLDARLVL HVLPRVCHAL RDLVRDRVTW
     RLRAQRRVRA PYPVVEEEDF DWPTACIELE QHLSRWADDG RRAEYFCLAD GHFASIDSVL
     LLQGGTLCLS GSRDRNVNLW DLQQLGVEPS RVLVKTLGTQ KNSTHKGWVW SLAALDHRVC
     SGSWDSTVKL WDMAADGQQF GEIKGKAAVL CLSYRPDILV TGTYDKKVTV YDPRVGPALL
     KSRRLHSSAV LALLADDRHI ISGSEDHTLV VFDRRANSVL QRLQLDSYLL CMSYQEPQLW
     AGDNQGLLHV FANRSGCFQL VRSFDVGHRS QITGIKHSLG ALYTTSTDKT IRVHVPTDPP
     RTICTRSHHN VLNGICAEGN LVVAASGGLS LEVWRLQA