FCA1_TRYBB
ID FCA1_TRYBB Reviewed; 233 AA.
AC P17882;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Flagellar calcium-binding protein TB-17;
DE AltName: Full=17 kDa calcimedin;
DE AltName: Full=17 kDa calflagin;
GN Name=FCABP;
OS Trypanosoma brucei brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=427;
RX PubMed=2198539; DOI=10.1093/nar/18.14.4252;
RA Lee M.G.-S., Chen J., Ho A.W.M., D'Alesandro P., van der Ploeg L.H.T.;
RT "A putative flagellar Ca2(+)-binding protein of the flagellum of
RT trypanosomatid protozoan parasites.";
RL Nucleic Acids Res. 18:4252-4252(1990).
CC -!- FUNCTION: May contribute to the rapid motility of the trypanosomes,
CC playing a role either in flagellar structure or in calcium metabolism.
CC Could alternate between a GDP-bound inactive form to a calcium/GTP-
CC bound active form.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum.
CC -!- DOMAIN: This protein has four EF-hand domains, three of which may be
CC functional calcium-binding sites.
CC -!- SIMILARITY: Belongs to the calflagin family. {ECO:0000305}.
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DR EMBL; X53464; CAA37558.1; -; mRNA.
DR PIR; S10515; AQUT17.
DR AlphaFoldDB; P17882; -.
DR SMR; P17882; -.
DR SwissPalm; P17882; -.
DR GO; GO:0005929; C:cilium; IDA:GeneDB.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; ISM:GeneDB.
DR GO; GO:0006816; P:calcium ion transport; TAS:GeneDB.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR003299; Calflagin-bd.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR PRINTS; PR01362; CALFLAGIN.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium; Cell projection; Cilium; Flagellum; Metal-binding; Repeat.
FT CHAIN 1..233
FT /note="Flagellar calcium-binding protein TB-17"
FT /id="PRO_0000073735"
FT DOMAIN 48..83
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 130..165
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 167..202
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 61
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 63
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 65
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 67
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 72
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 143
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 145
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 147
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 154
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000305"
FT BINDING 180
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 182
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 184
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 191
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 233 AA; 25492 MW; 2ACF56FA38D08FC9 CRC64;
MGCSGSKNAS NPKDGAASKG GKDGKTTADR KVAWERIRCA IPRDKDAESK SRRIELFKQF
DTNGTGKLGF REVLDGCYSI LKLDEFTTHL PDIVQRAFDK AKDLGNKVKG VGEEDLVEFL
EFRLMLCYIY DIFELTVIFD TMDKDGSLLL ELHEFKEALP KLKEWGVDIT DATTVFNEID
TNGSGVVTFD EFSCWAVTKK LQVSGDPDDE ENGANEGDGA NAGDGVPAAE GSA
