FCAMR_HUMAN
ID FCAMR_HUMAN Reviewed; 532 AA.
AC Q8WWV6; Q32M82; Q8WWV5; Q96SA2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor;
DE AltName: Full=Fc alpha/mu receptor;
DE AltName: CD_antigen=CD351;
DE Flags: Precursor;
GN Name=FCAMR; ORFNames=FKSG87;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Lymph node;
RX PubMed=11062505; DOI=10.1038/80886;
RA Shibuya A., Sakamoto N., Shimizu Y., Shibuya K., Osawa M., Hiroyama T.,
RA Eyre H.J., Sutherland G.R., Endo Y., Fujita T., Miyabayashi T., Sakano S.,
RA Tsuji T., Nakayama E., Phillips J.H., Lanier L.L., Nakauchi H.;
RT "Fc alpha/mu receptor mediates endocytosis of IgM-coated microbes.";
RL Nat. Immunol. 1:441-446(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF
RP 303-532 (ISOFORM 4), FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY, AND
RP INDUCTION BY IFNG.
RX PubMed=11779189; DOI=10.1006/bbrc.2001.6218;
RA McDonald K.J., Cameron A.J.M., Allen J.M., Jardine A.G.;
RT "Expression of Fc alpha/mu receptor by human mesangial cells: a candidate
RT receptor for immune complex deposition in IgA nephropathy.";
RL Biochem. Biophys. Res. Commun. 290:438-442(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RA Wang Y.-G., Gong L.;
RT "Molecular cloning and characterization of FKSG87, a novel gene located on
RT human chromosome 1.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Functions as a receptor for the Fc fragment of IgA and IgM.
CC Binds IgA and IgM with high affinity and mediates their endocytosis.
CC May function in the immune response to microbes mediated by IgA and
CC IgM. {ECO:0000269|PubMed:11779189}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8WWV6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8WWV6-2; Sequence=VSP_033228, VSP_033229;
CC Name=3;
CC IsoId=Q8WWV6-3; Sequence=VSP_033227, VSP_033230, VSP_033232;
CC Name=4;
CC IsoId=Q8WWV6-4; Sequence=VSP_033231;
CC -!- TISSUE SPECIFICITY: Expressed by mesangial cells.
CC {ECO:0000269|PubMed:11779189}.
CC -!- INDUCTION: Up-regulated by IFNG/IFN-gamma in mesangial cells.
CC {ECO:0000269|PubMed:11779189}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:11779189}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI09264.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI09265.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; E15470; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY063125; AAL51154.1; -; mRNA.
DR EMBL; AY063126; AAL51155.1; -; mRNA.
DR EMBL; AF354295; AAK39522.1; -; mRNA.
DR EMBL; BC109263; AAI09264.1; ALT_INIT; mRNA.
DR EMBL; BC109264; AAI09265.1; ALT_INIT; mRNA.
DR RefSeq; NP_001116451.1; NM_001122979.2.
DR RefSeq; NP_114418.2; NM_032029.4.
DR AlphaFoldDB; Q8WWV6; -.
DR SMR; Q8WWV6; -.
DR BioGRID; 123827; 1.
DR IntAct; Q8WWV6; 1.
DR STRING; 9606.ENSP00000316491; -.
DR GlyGen; Q8WWV6; 5 sites, 1 O-linked glycan (4 sites).
DR iPTMnet; Q8WWV6; -.
DR PhosphoSitePlus; Q8WWV6; -.
DR BioMuta; FCAMR; -.
DR DMDM; 74760589; -.
DR MassIVE; Q8WWV6; -.
DR PaxDb; Q8WWV6; -.
DR PeptideAtlas; Q8WWV6; -.
DR PRIDE; Q8WWV6; -.
DR ProteomicsDB; 74940; -. [Q8WWV6-1]
DR ProteomicsDB; 74941; -. [Q8WWV6-2]
DR ProteomicsDB; 74942; -. [Q8WWV6-3]
DR ProteomicsDB; 74943; -. [Q8WWV6-4]
DR Antibodypedia; 57057; 51 antibodies from 17 providers.
DR DNASU; 83953; -.
DR Ensembl; ENST00000400962.8; ENSP00000383746.3; ENSG00000162897.16.
DR Ensembl; ENST00000450945.3; ENSP00000392707.2; ENSG00000162897.16.
DR GeneID; 83953; -.
DR KEGG; hsa:83953; -.
DR UCSC; uc001hfb.3; human. [Q8WWV6-1]
DR CTD; 83953; -.
DR DisGeNET; 83953; -.
DR GeneCards; FCAMR; -.
DR HGNC; HGNC:24692; FCAMR.
DR HPA; ENSG00000162897; Group enriched (kidney, lymphoid tissue).
DR MIM; 605484; gene.
DR neXtProt; NX_Q8WWV6; -.
DR PharmGKB; PA142671773; -.
DR VEuPathDB; HostDB:ENSG00000162897; -.
DR eggNOG; ENOG502SNZE; Eukaryota.
DR HOGENOM; CLU_1049554_0_0_1; -.
DR InParanoid; Q8WWV6; -.
DR PhylomeDB; Q8WWV6; -.
DR PathwayCommons; Q8WWV6; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR SignaLink; Q8WWV6; -.
DR BioGRID-ORCS; 83953; 9 hits in 1060 CRISPR screens.
DR GenomeRNAi; 83953; -.
DR Pharos; Q8WWV6; Tbio.
DR PRO; PR:Q8WWV6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8WWV6; protein.
DR Bgee; ENSG00000162897; Expressed in kidney epithelium and 37 other tissues.
DR ExpressionAtlas; Q8WWV6; baseline and differential.
DR Genevisible; Q8WWV6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Alternative splicing; Cell membrane; Disulfide bond;
KW Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..532
FT /note="High affinity immunoglobulin alpha and
FT immunoglobulin mu Fc receptor"
FT /id="PRO_0000331483"
FT TOPO_DOM 17..450
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 472..532
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 61..169
FT /note="Ig-like V-type"
FT REGION 75..97
FT /note="Mediates immunoglobulin Fc fragment-binding"
FT /evidence="ECO:0000250"
FT REGION 197..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 397..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..311
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 82..153
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..11
FT /note="MPLFLILCLLQ -> MDGEATVKPGEQVPLWTHGWPPDDPSPSFAA (in
FT isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_033227"
FT VAR_SEQ 173..220
FT /note="GPASTLPTATPAAGELTMRSYGTASPVANRWTPGTTQTLGQGTAWDTV ->
FT VLFQKMKAALGPWLLSLPCWPCLCLWLWFYCKGSSGEGGPLRRQKGSP (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033228"
FT VAR_SEQ 221..532
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033229"
FT VAR_SEQ 383..391
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_033230"
FT VAR_SEQ 441..532
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11779189"
FT /id="VSP_033231"
FT VAR_SEQ 441..480
FT /note="TFPEDESSSRTLAPVSTMLALFMLMALVLLQRKLWRRRTS -> ATCPGLST
FT LKEIKVSAVLTQNPHSLLCVSAA (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_033232"
SQ SEQUENCE 532 AA; 57144 MW; D347A23C0F41EED3 CRC64;
MPLFLILCLL QGSSFALPQK RPHPRWLWEG SLPSRTHLRA MGTLRPSSPL CWREESSFAA
PNSLKGSRLV SGEPGGAVTI QCHYAPSSVN RHQRKYWCRL GPPRWICQTI VSTNQYTHHR
YRDRVALTDF PQRGLFVVRL SQLSPDDIGC YLCGIGSENN MLFLSMNLTI SAGPASTLPT
ATPAAGELTM RSYGTASPVA NRWTPGTTQT LGQGTAWDTV ASTPGTSKTT ASAEGRRTPG
ATRPAAPGTG SWAEGSVKAP APIPESPPSK SRSMSNTTEG VWEGTRSSVT NRARASKDRR
EMTTTKADRP REDIEGVRIA LDAAKKVLGT IGPPALVSET LAWEILPQAT PVSKQQSQGS
IGETTPAAGM WTLGTPAADV WILGTPAADV WTSMEAASGE GSAAGDLDAA TGDRGPQATL
SQTPAVGPWG PPGKESSVKR TFPEDESSSR TLAPVSTMLA LFMLMALVLL QRKLWRRRTS
QEAERVTLIQ MTHFLEVNPQ ADQLPHVERK MLQDDSLPAG ASLTAPERNP GP
