FCAP_APLCA
ID FCAP_APLCA Reviewed; 742 AA.
AC Q8ISH7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=Feeding circuit activating peptides;
DE Short=FCAP;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide a;
DE Short=FCAPa;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide b;
DE Short=FCAPb;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide c;
DE Short=FCAPc;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide d;
DE Short=FCAPd;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide e;
DE Short=FCAPe;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide f;
DE Short=FCAPf;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide g;
DE Short=FCAPg;
DE Contains:
DE RecName: Full=Feeding circuit activating peptide h;
DE Short=FCAPh;
DE Flags: Precursor;
OS Aplysia californica (California sea hare).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC Aplysiidae; Aplysia.
OX NCBI_TaxID=6500;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, PROTEOLYTIC
RP PROCESSING, AND MASS SPECTROMETRY.
RX PubMed=12196603; DOI=10.1523/jneurosci.22-17-07797.2002;
RA Sweedler J.V., Li L., Rubakhin S.S., Alexeeva V., Dembrow N.C., Dowling O.,
RA Jing J., Weiss K.R., Vilim F.S.;
RT "Identification and characterization of the feeding circuit-activating
RT peptides, a novel neuropeptide family of Aplysia.";
RL J. Neurosci. 22:7797-7808(2002).
CC -!- FUNCTION: Initiates organized rhythmic motor output of feeding circuit.
CC {ECO:0000269|PubMed:12196603}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in pleural, pedal, abdominal, buccal and
CC cerebral ganglia. {ECO:0000269|PubMed:12196603}.
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide a]:
CC Mass=1425.679; Mass_error=0.023; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide b]:
CC Mass=1385.731; Mass_error=0.094; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide c]:
CC Mass=1399.654; Mass_error=0.034; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide d]:
CC Mass=1497.765; Mass_error=0.017; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide e]:
CC Mass=1369.741; Mass_error=0.067; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide f]:
CC Mass=1428.701; Mass_error=0.022; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide g]:
CC Mass=1431.725; Mass_error=0.047; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
CC -!- MASS SPECTROMETRY: [Feeding circuit activating peptide h]:
CC Mass=1484.781; Mass_error=0.065; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:12196603};
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DR EMBL; AY118084; AAM80561.1; -; mRNA.
DR RefSeq; NP_001191518.1; NM_001204589.1.
DR AlphaFoldDB; Q8ISH7; -.
DR GeneID; 100533286; -.
DR OrthoDB; 1295145at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR040384; FCAP.
DR PANTHER; PTHR33864; PTHR33864; 1.
PE 1: Evidence at protein level;
KW Hormone; Neuropeptide; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..98
FT /id="PRO_0000306123"
FT PEPTIDE 101..113
FT /note="Feeding circuit activating peptide a"
FT /id="PRO_0000306124"
FT PROPEP 117..131
FT /note="Connecting peptide"
FT /id="PRO_0000306125"
FT PEPTIDE 134..146
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306126"
FT PEPTIDE 149..161
FT /note="Feeding circuit activating peptide c"
FT /id="PRO_0000306127"
FT PROPEP 164..168
FT /id="PRO_0000306150"
FT PEPTIDE 171..183
FT /note="Feeding circuit activating peptide d"
FT /id="PRO_0000306128"
FT PEPTIDE 187..199
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306129"
FT PROPEP 202..220
FT /id="PRO_0000306151"
FT PEPTIDE 222..233
FT /note="Feeding circuit activating peptide e"
FT /id="PRO_0000306130"
FT PROPEP 236..253
FT /id="PRO_0000306152"
FT PEPTIDE 256..268
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306131"
FT PROPEP 271..275
FT /id="PRO_0000306153"
FT PEPTIDE 278..290
FT /note="Feeding circuit activating peptide f"
FT /id="PRO_0000306132"
FT PROPEP 293..297
FT /id="PRO_0000306154"
FT PEPTIDE 300..312
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306133"
FT PROPEP 315..321
FT /id="PRO_0000306155"
FT PEPTIDE 324..336
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306134"
FT PROPEP 339..341
FT /id="PRO_0000306156"
FT PEPTIDE 344..356
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306135"
FT PROPEP 359..366
FT /id="PRO_0000306157"
FT PEPTIDE 369..381
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306136"
FT PROPEP 384..388
FT /id="PRO_0000306158"
FT PEPTIDE 391..403
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306137"
FT PROPEP 406..410
FT /id="PRO_0000306159"
FT PEPTIDE 413..425
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306138"
FT PROPEP 428..432
FT /id="PRO_0000306160"
FT PEPTIDE 435..447
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306139"
FT PROPEP 450..454
FT /id="PRO_0000306161"
FT PEPTIDE 457..469
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306140"
FT PROPEP 472..476
FT /id="PRO_0000306162"
FT PEPTIDE 479..491
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306141"
FT PROPEP 494..498
FT /id="PRO_0000306163"
FT PEPTIDE 501..513
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306142"
FT PROPEP 516..520
FT /id="PRO_0000306164"
FT PEPTIDE 523..535
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306143"
FT PROPEP 538..542
FT /id="PRO_0000306165"
FT PEPTIDE 545..557
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306144"
FT PROPEP 560..564
FT /id="PRO_0000306166"
FT PEPTIDE 567..579
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306145"
FT PROPEP 582..592
FT /id="PRO_0000306167"
FT PEPTIDE 595..607
FT /note="Feeding circuit activating peptide b"
FT /id="PRO_0000306146"
FT PROPEP 610..614
FT /id="PRO_0000306168"
FT PEPTIDE 617..629
FT /note="Feeding circuit activating peptide g"
FT /id="PRO_0000306147"
FT PEPTIDE 632..644
FT /note="Feeding circuit activating peptide h"
FT /id="PRO_0000306148"
FT PROPEP 647..742
FT /id="PRO_0000306149"
SQ SEQUENCE 742 AA; 82576 MW; FEFBF6018835FA16 CRC64;
MTFAASFRAL LCVLFCAALV HCKTRTKRYV PHSELWRILA VVDELQREQA AEQRQEDALA
LALRSDIAGG GGGGQLADNV RWFPETYDYG ALADRDVDKR VFDSLGGYEV HGFKKRGSLD
AIPQDTDASS DKRALDSLGG FQVHGWKRAL DTLGGFQVHG WKRGSGAEKR QVDRLGGFQV
HGWKKRALDS LGGFQVHGWK KRGTGGQMHA SSPRVVPWGS RSLLADTQSG HRWKRDTELV
ENRQTTGQQT EVNKRALDSL GGFQVHGWKR SGEAGKRQVD SLGGFQVHGW KRADDQGKRA
LDSLGGFQVH GWKRFDNSAG EKRALDSLGG FQVHGWKRAG DKKSLDSLGS FQVHGWKRFD
NDISGQKRSL DSLGSFQVHG WKRSDQDNKR ALDSLGGFQV HGWKRADDDG KRSLDSLGSF
QVHGWKRADE DDKKSLDSLG SFQVHGWKRG DEDDKRSLDS LGSFQVHGWK RADEDDKRSL
DSLGSFQVHG WKRSDEDDKR SLDSLGSFQV HGWKRSDEDD KRSLDSLGSF QVHGWKRADE
DDKRSLDSLG SFQVHGWKRN SPGLKRALDS LGGFQVHGWK RNNEYYSGAE NEKRALDSLG
GFQVHGWKRD QPGEKRSLDS LGSFQVHGWK RNLNNLGSFQ VHGWKKNSAD EMGDKPGVES
YQDNSGKILS GKAQEFEGGD ETGDIHGVVR TLSGVDASGK ERENIKELDA KFKTNDGGVG
VEHIFVDNVK SADDDVPSAG QM
