FCAR_HUMAN
ID FCAR_HUMAN Reviewed; 287 AA.
AC P24071; Q13603; Q13604; Q15727; Q15728; Q1AJL7; Q1AJL8; Q1AJL9; Q53X38;
AC Q53X39; Q92587; Q92588; Q92590; Q92592; Q92593; Q9UEK0;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 201.
DE RecName: Full=Immunoglobulin alpha Fc receptor;
DE Short=IgA Fc receptor;
DE AltName: CD_antigen=CD89;
DE Flags: Precursor;
GN Name=FCAR; Synonyms=CD89;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1).
RX PubMed=2258698; DOI=10.1084/jem.172.6.1665;
RA Maliszewski C.R., March C.J., Schoenborn M.A., Gimpel S., Shen L.;
RT "Expression cloning of a human Fc receptor for IgA.";
RL J. Exp. Med. 172:1665-1672(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A.1).
RC TISSUE=Bone marrow;
RX PubMed=7636188;
RA de Wit T.P.M., Morton H.C., Capel P.J.A., van de Winkel J.G.J.;
RT "Structure of the gene for the human myeloid IgA Fc receptor (CD89).";
RL J. Immunol. 155:1203-1209(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2 AND A.3), AND TISSUE SPECIFICITY.
RC TISSUE=Alveolar macrophage, and Monocyte;
RX PubMed=8666819;
RA Patry C., Sibille Y., Lehuen A., Monteiro R.C.;
RT "Identification of Fc alpha receptor (CD89) isoforms generated by
RT alternative splicing that are differentially expressed between blood
RT monocytes and alveolar macrophages.";
RL J. Immunol. 156:4442-4448(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE (ISOFORMS B AND B-DELTA-S2).
RA van Dijk T.B., Morton H.C., Caldenhoven E., Bracke M., Raaijmakers J.A.M.,
RA Lammers J.W.J., Koenderman L., Groot R.P.;
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.3), AND TISSUE SPECIFICITY.
RX PubMed=8836118; DOI=10.1042/bj3180771;
RA Pleass R.J., Andrews P.D., Kerr M.A., Woof J.M.;
RT "Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and
RT eosinophils.";
RL Biochem. J. 318:771-777(1996).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A.2; A.3; L10; U02; U09; U10; U11 AND
RP U13).
RX PubMed=9367406; DOI=10.1111/j.1365-2249.1997.tb08321.x;
RA Toyabe S., Kuwano Y., Takeda K., Uchiyama M., Abo T.;
RT "IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on
RT blood phagocytic cells.";
RL Clin. Exp. Immunol. 110:226-232(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A.1), AND VARIANTS ASN-113 AND GLY-269.
RX PubMed=17548632; DOI=10.4049/jimmunol.178.12.7943;
RA Abi-Rached L., Dorighi K., Norman P.J., Yawata M., Parham P.;
RT "Episodes of natural selection shaped the interactions of IgA-Fc with
RT FcalphaRI and bacterial decoy proteins.";
RL J. Immunol. 178:7943-7954(2007).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A.1).
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [10]
RP SUBUNIT.
RX PubMed=7522255;
RA Pfefferkorn L.C., Yeaman G.R.;
RT "Association of IgA-Fc receptors (Fc alpha R) with Fc epsilon RI gamma 2
RT subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of
RT gamma 2.";
RL J. Immunol. 153:3228-3236(1994).
RN [11]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
RN [12]
RP INTERACTION WITH STAPHYLOCOCCUS AUREUS PROTEIN SSL11 (MICROBIAL INFECTION).
RX PubMed=18045383; DOI=10.1111/j.1365-2958.2007.05989.x;
RA Chung M.C., Wines B.D., Baker H., Langley R.J., Baker E.N., Fraser J.D.;
RT "The crystal structure of staphylococcal superantigen-like protein 11 in
RT complex with sialyl Lewis X reveals the mechanism for cell binding and
RT immune inhibition.";
RL Mol. Microbiol. 66:1342-1355(2007).
RN [13]
RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-229, AND DISULFIDE BONDS.
RX PubMed=12783876; DOI=10.1074/jbc.c300223200;
RA Ding Y., Xu G., Yang M., Yao M., Gao G.F., Wang L., Zhang W., Rao Z.;
RT "Crystal structure of the ectodomain of human FcalphaRI.";
RL J. Biol. Chem. 278:27966-27970(2003).
RN [14]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-216 IN COMPLEX WITH
RP IMMUNOGLOBULIN ALPHA, FUNCTION, DISULFIDE BONDS, AND GLYCOSYLATION AT
RP ASN-141 AND ASN-177.
RX PubMed=12768205; DOI=10.1038/nature01685;
RA Herr A.B., Ballister E.R., Bjorkman P.J.;
RT "Insights into IgA-mediated immune responses from the crystal structures of
RT human FcalphaRI and its complex with IgA1-Fc.";
RL Nature 423:614-620(2003).
CC -!- FUNCTION: Binds to the Fc region of immunoglobulins alpha. Mediates
CC several functions including cytokine production.
CC {ECO:0000269|PubMed:12768205}.
CC -!- SUBUNIT: Associates with the Fc epsilon RI gamma 2 receptor inducing
CC tyrosine phosphorylation of gamma 2. {ECO:0000269|PubMed:12768205,
CC ECO:0000269|PubMed:7522255}.
CC -!- SUBUNIT: (Microbial infection) Interacts with Staphylococcus aureus
CC protein SSL11. {ECO:0000269|PubMed:18045383}.
CC -!- SUBCELLULAR LOCATION: [Isoform A.1]: Cell membrane; Single-pass type I
CC membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform A.2]: Cell membrane; Single-pass type I
CC membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform A.3]: Cell membrane; Single-pass type I
CC membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform B]: Secreted.
CC -!- SUBCELLULAR LOCATION: [Isoform B-delta-S2]: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=11;
CC Comment=Additional isoforms seem to exist.;
CC Name=A.1;
CC IsoId=P24071-1; Sequence=Displayed;
CC Name=A.2;
CC IsoId=P24071-2; Sequence=VSP_002635;
CC Name=A.3; Synonyms=RLA2;
CC IsoId=P24071-3; Sequence=VSP_002634;
CC Name=B;
CC IsoId=P24071-4; Sequence=VSP_002636;
CC Name=B-delta-S2;
CC IsoId=P24071-5; Sequence=VSP_002632, VSP_002636;
CC Name=U02;
CC IsoId=P24071-6; Sequence=VSP_002633, VSP_002635;
CC Name=L10;
CC IsoId=P24071-7; Sequence=VSP_002632, VSP_043565;
CC Name=U09;
CC IsoId=P24071-8; Sequence=VSP_002632, VSP_043567;
CC Name=U10;
CC IsoId=P24071-9; Sequence=VSP_002632, VSP_043566;
CC Name=U11;
CC IsoId=P24071-10; Sequence=VSP_002632;
CC Name=U13;
CC IsoId=P24071-11; Sequence=VSP_002632, VSP_002635;
CC -!- TISSUE SPECIFICITY: Isoform A.1, isoform A.2 and isoform A.3 are
CC differentially expressed between blood and mucosal myeloid cells.
CC Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes.
CC Isoform A.1 and isoform A.2 are expressed in alveolar macrophages;
CC however only one isoform is expressed at alveolar macrophages surfaces.
CC {ECO:0000269|PubMed:8666819, ECO:0000269|PubMed:8836118}.
CC -!- MISCELLANEOUS: [Isoform B-delta-S2]: May be produced at very low levels
CC due to a premature stop codon in the mRNA, leading to nonsense-mediated
CC mRNA decay. {ECO:0000305}.
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DR EMBL; X54150; CAA38089.1; -; mRNA.
DR EMBL; X87767; CAA61039.1; -; Genomic_DNA.
DR EMBL; X87768; CAA61039.1; JOINED; Genomic_DNA.
DR EMBL; X87769; CAA61039.1; JOINED; Genomic_DNA.
DR EMBL; X87766; CAA61039.1; JOINED; Genomic_DNA.
DR EMBL; X87765; CAA61039.1; JOINED; Genomic_DNA.
DR EMBL; U43774; AAC50639.1; -; mRNA.
DR EMBL; U43677; AAC50595.1; -; mRNA.
DR EMBL; U56236; AAB00566.1; -; mRNA.
DR EMBL; U56237; AAB00567.1; -; mRNA.
DR EMBL; S82919; AAD14421.1; -; mRNA.
DR EMBL; D87853; BAA13471.1; -; mRNA.
DR EMBL; D87854; BAA13472.1; -; mRNA.
DR EMBL; D87855; BAA13473.1; -; mRNA.
DR EMBL; D87856; BAA13474.1; -; mRNA.
DR EMBL; D87857; BAA13475.1; -; mRNA.
DR EMBL; D87859; BAA13477.1; -; mRNA.
DR EMBL; D87861; BAA13479.1; -; mRNA.
DR EMBL; D87862; BAA13480.1; -; mRNA.
DR EMBL; DQ075334; AAZ76577.1; -; mRNA.
DR EMBL; DQ075335; AAZ76578.1; -; mRNA.
DR EMBL; DQ075336; AAZ76579.1; -; mRNA.
DR EMBL; DQ075337; AAZ76580.1; -; mRNA.
DR EMBL; DQ075338; AAZ76581.1; -; mRNA.
DR EMBL; DQ075339; AAZ76582.1; -; mRNA.
DR EMBL; AC011501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027953; AAH27953.1; -; mRNA.
DR CCDS; CCDS12907.1; -. [P24071-1]
DR CCDS; CCDS12908.1; -. [P24071-3]
DR CCDS; CCDS12909.1; -. [P24071-10]
DR CCDS; CCDS12910.1; -. [P24071-7]
DR CCDS; CCDS42622.1; -. [P24071-2]
DR CCDS; CCDS42623.1; -. [P24071-11]
DR CCDS; CCDS42624.1; -. [P24071-9]
DR CCDS; CCDS42625.1; -. [P24071-8]
DR PIR; G02630; G02630.
DR PIR; JH0332; JH0332.
DR RefSeq; NP_001991.1; NM_002000.3. [P24071-1]
DR RefSeq; NP_579803.1; NM_133269.3. [P24071-2]
DR RefSeq; NP_579805.1; NM_133271.3. [P24071-3]
DR RefSeq; NP_579806.1; NM_133272.3. [P24071-10]
DR RefSeq; NP_579807.1; NM_133273.3. [P24071-9]
DR RefSeq; NP_579808.1; NM_133274.3. [P24071-8]
DR RefSeq; NP_579811.1; NM_133277.3. [P24071-7]
DR RefSeq; NP_579812.1; NM_133278.3. [P24071-11]
DR PDB; 1OVZ; X-ray; 3.00 A; A/B=22-216.
DR PDB; 1OW0; X-ray; 3.10 A; C/D=22-216.
DR PDB; 1UCT; X-ray; 2.10 A; A=21-229.
DR PDBsum; 1OVZ; -.
DR PDBsum; 1OW0; -.
DR PDBsum; 1UCT; -.
DR AlphaFoldDB; P24071; -.
DR SMR; P24071; -.
DR BioGRID; 108498; 7.
DR IntAct; P24071; 4.
DR STRING; 9606.ENSP00000347714; -.
DR GuidetoPHARMACOLOGY; 2991; -.
DR MEROPS; I43.951; -.
DR GlyGen; P24071; 5 sites.
DR iPTMnet; P24071; -.
DR PhosphoSitePlus; P24071; -.
DR BioMuta; FCAR; -.
DR DMDM; 119860; -.
DR MassIVE; P24071; -.
DR PaxDb; P24071; -.
DR PeptideAtlas; P24071; -.
DR PRIDE; P24071; -.
DR ProteomicsDB; 54181; -. [P24071-1]
DR ProteomicsDB; 54182; -. [P24071-10]
DR ProteomicsDB; 54183; -. [P24071-11]
DR ProteomicsDB; 54184; -. [P24071-2]
DR ProteomicsDB; 54185; -. [P24071-3]
DR ProteomicsDB; 54186; -. [P24071-4]
DR ProteomicsDB; 54187; -. [P24071-5]
DR ProteomicsDB; 54188; -. [P24071-6]
DR ProteomicsDB; 54189; -. [P24071-7]
DR ProteomicsDB; 54190; -. [P24071-8]
DR ProteomicsDB; 54191; -. [P24071-9]
DR Antibodypedia; 2709; 883 antibodies from 40 providers.
DR DNASU; 2204; -.
DR Ensembl; ENST00000345937.8; ENSP00000338257.4; ENSG00000186431.19. [P24071-3]
DR Ensembl; ENST00000353758.8; ENSP00000338058.4; ENSG00000186431.19. [P24071-7]
DR Ensembl; ENST00000355524.8; ENSP00000347714.3; ENSG00000186431.19. [P24071-1]
DR Ensembl; ENST00000359272.8; ENSP00000352218.4; ENSG00000186431.19. [P24071-10]
DR Ensembl; ENST00000391723.7; ENSP00000375603.3; ENSG00000186431.19. [P24071-8]
DR Ensembl; ENST00000391724.3; ENSP00000375604.3; ENSG00000186431.19. [P24071-11]
DR Ensembl; ENST00000391725.7; ENSP00000375605.3; ENSG00000186431.19. [P24071-2]
DR Ensembl; ENST00000391726.7; ENSP00000375606.3; ENSG00000186431.19. [P24071-9]
DR Ensembl; ENST00000469767.5; ENSP00000473814.1; ENSG00000186431.19. [P24071-4]
DR Ensembl; ENST00000488066.5; ENSP00000474512.1; ENSG00000186431.19. [P24071-5]
DR Ensembl; ENST00000610340.4; ENSP00000477610.1; ENSG00000275136.4. [P24071-8]
DR Ensembl; ENST00000610397.4; ENSP00000480965.1; ENSG00000275269.4. [P24071-3]
DR Ensembl; ENST00000610786.4; ENSP00000483121.1; ENSG00000276858.4. [P24071-8]
DR Ensembl; ENST00000611018.4; ENSP00000484483.1; ENSG00000275970.4. [P24071-11]
DR Ensembl; ENST00000611130.4; ENSP00000484917.1; ENSG00000273738.4. [P24071-11]
DR Ensembl; ENST00000611871.4; ENSP00000482976.1; ENSG00000273738.4. [P24071-10]
DR Ensembl; ENST00000611943.4; ENSP00000482273.1; ENSG00000275564.4. [P24071-2]
DR Ensembl; ENST00000612150.4; ENSP00000478233.1; ENSG00000275136.4. [P24071-3]
DR Ensembl; ENST00000612159.4; ENSP00000484662.1; ENSG00000276985.4. [P24071-9]
DR Ensembl; ENST00000612505.4; ENSP00000479792.1; ENSG00000276985.4. [P24071-8]
DR Ensembl; ENST00000612803.4; ENSP00000478454.1; ENSG00000275970.4. [P24071-8]
DR Ensembl; ENST00000612815.4; ENSP00000483503.1; ENSG00000275269.4. [P24071-8]
DR Ensembl; ENST00000612918.4; ENSP00000482056.1; ENSG00000274580.4. [P24071-3]
DR Ensembl; ENST00000613199.4; ENSP00000478465.1; ENSG00000276858.4. [P24071-1]
DR Ensembl; ENST00000613201.4; ENSP00000482108.1; ENSG00000274580.4. [P24071-4]
DR Ensembl; ENST00000613298.4; ENSP00000482451.1; ENSG00000275269.4. [P24071-9]
DR Ensembl; ENST00000613318.4; ENSP00000481560.1; ENSG00000273738.4. [P24071-4]
DR Ensembl; ENST00000613663.4; ENSP00000483437.1; ENSG00000275564.4. [P24071-4]
DR Ensembl; ENST00000613685.4; ENSP00000481230.1; ENSG00000275564.4. [P24071-11]
DR Ensembl; ENST00000614226.4; ENSP00000483099.1; ENSG00000276985.4. [P24071-1]
DR Ensembl; ENST00000614298.4; ENSP00000483472.1; ENSG00000275970.4. [P24071-9]
DR Ensembl; ENST00000614433.4; ENSP00000480748.1; ENSG00000276985.4. [P24071-2]
DR Ensembl; ENST00000614689.4; ENSP00000480013.1; ENSG00000273738.4. [P24071-5]
DR Ensembl; ENST00000614893.4; ENSP00000477966.1; ENSG00000273738.4. [P24071-2]
DR Ensembl; ENST00000614917.4; ENSP00000479831.1; ENSG00000275970.4. [P24071-2]
DR Ensembl; ENST00000614954.4; ENSP00000479924.1; ENSG00000276858.4. [P24071-9]
DR Ensembl; ENST00000615040.4; ENSP00000477656.1; ENSG00000276858.4. [P24071-10]
DR Ensembl; ENST00000615110.4; ENSP00000484276.1; ENSG00000274580.4. [P24071-2]
DR Ensembl; ENST00000615361.4; ENSP00000482741.1; ENSG00000273738.4. [P24071-9]
DR Ensembl; ENST00000615703.4; ENSP00000484868.1; ENSG00000275136.4. [P24071-4]
DR Ensembl; ENST00000615719.1; ENSP00000482518.1; ENSG00000275136.4. [P24071-7]
DR Ensembl; ENST00000615800.4; ENSP00000483841.1; ENSG00000276985.4. [P24071-4]
DR Ensembl; ENST00000615829.4; ENSP00000482623.1; ENSG00000274580.4. [P24071-1]
DR Ensembl; ENST00000615937.4; ENSP00000478075.1; ENSG00000274580.4. [P24071-11]
DR Ensembl; ENST00000616340.4; ENSP00000481676.1; ENSG00000275269.4. [P24071-10]
DR Ensembl; ENST00000616878.4; ENSP00000480970.1; ENSG00000275136.4. [P24071-9]
DR Ensembl; ENST00000616969.4; ENSP00000479039.1; ENSG00000275564.4. [P24071-5]
DR Ensembl; ENST00000617025.4; ENSP00000481129.1; ENSG00000276985.4. [P24071-3]
DR Ensembl; ENST00000617609.4; ENSP00000481394.1; ENSG00000274580.4. [P24071-10]
DR Ensembl; ENST00000617696.4; ENSP00000482670.1; ENSG00000274580.4. [P24071-9]
DR Ensembl; ENST00000617762.4; ENSP00000484136.1; ENSG00000276858.4. [P24071-5]
DR Ensembl; ENST00000617766.4; ENSP00000479230.1; ENSG00000275269.4. [P24071-4]
DR Ensembl; ENST00000617778.4; ENSP00000480498.1; ENSG00000273738.4. [P24071-3]
DR Ensembl; ENST00000617964.1; ENSP00000484141.1; ENSG00000275564.4. [P24071-7]
DR Ensembl; ENST00000618271.1; ENSP00000484741.1; ENSG00000276985.4. [P24071-7]
DR Ensembl; ENST00000618287.4; ENSP00000481668.1; ENSG00000275564.4. [P24071-10]
DR Ensembl; ENST00000618328.4; ENSP00000480496.1; ENSG00000276985.4. [P24071-10]
DR Ensembl; ENST00000618658.4; ENSP00000479688.1; ENSG00000275970.4. [P24071-4]
DR Ensembl; ENST00000618805.4; ENSP00000481985.1; ENSG00000275269.4. [P24071-2]
DR Ensembl; ENST00000618985.4; ENSP00000480323.1; ENSG00000275269.4. [P24071-5]
DR Ensembl; ENST00000619073.4; ENSP00000479360.1; ENSG00000273738.4. [P24071-8]
DR Ensembl; ENST00000619155.4; ENSP00000480461.1; ENSG00000275970.4. [P24071-5]
DR Ensembl; ENST00000619385.4; ENSP00000482334.1; ENSG00000275269.4. [P24071-1]
DR Ensembl; ENST00000619414.4; ENSP00000478163.1; ENSG00000276858.4. [P24071-2]
DR Ensembl; ENST00000619822.4; ENSP00000483250.1; ENSG00000275136.4. [P24071-2]
DR Ensembl; ENST00000620162.4; ENSP00000483258.1; ENSG00000276858.4. [P24071-11]
DR Ensembl; ENST00000620179.1; ENSP00000478315.1; ENSG00000278415.4. [P24071-7]
DR Ensembl; ENST00000620270.4; ENSP00000482022.1; ENSG00000276985.4. [P24071-11]
DR Ensembl; ENST00000620397.4; ENSP00000477584.1; ENSG00000276985.4. [P24071-5]
DR Ensembl; ENST00000620801.4; ENSP00000481195.1; ENSG00000275970.4. [P24071-1]
DR Ensembl; ENST00000620822.1; ENSP00000483327.1; ENSG00000275269.4. [P24071-7]
DR Ensembl; ENST00000620873.4; ENSP00000479099.1; ENSG00000275269.4. [P24071-11]
DR Ensembl; ENST00000621004.4; ENSP00000484816.1; ENSG00000275970.4. [P24071-10]
DR Ensembl; ENST00000621009.4; ENSP00000482025.1; ENSG00000275970.4. [P24071-3]
DR Ensembl; ENST00000621289.4; ENSP00000481366.1; ENSG00000275136.4. [P24071-5]
DR Ensembl; ENST00000621417.4; ENSP00000478634.1; ENSG00000274580.4. [P24071-5]
DR Ensembl; ENST00000621684.4; ENSP00000479239.1; ENSG00000276858.4. [P24071-3]
DR Ensembl; ENST00000621702.4; ENSP00000482807.1; ENSG00000275136.4. [P24071-1]
DR Ensembl; ENST00000621755.1; ENSP00000484906.1; ENSG00000275970.4. [P24071-7]
DR Ensembl; ENST00000621882.1; ENSP00000484272.1; ENSG00000274580.4. [P24071-7]
DR Ensembl; ENST00000622157.4; ENSP00000481502.1; ENSG00000275564.4. [P24071-1]
DR Ensembl; ENST00000622470.1; ENSP00000477673.1; ENSG00000276858.4. [P24071-7]
DR Ensembl; ENST00000622491.4; ENSP00000477643.1; ENSG00000274580.4. [P24071-8]
DR Ensembl; ENST00000622543.4; ENSP00000483402.1; ENSG00000275564.4. [P24071-3]
DR Ensembl; ENST00000622646.1; ENSP00000480406.1; ENSG00000273738.4. [P24071-7]
DR Ensembl; ENST00000622737.4; ENSP00000479738.1; ENSG00000273738.4. [P24071-1]
DR Ensembl; ENST00000622777.4; ENSP00000481345.1; ENSG00000275136.4. [P24071-10]
DR Ensembl; ENST00000622883.4; ENSP00000479880.1; ENSG00000276858.4. [P24071-4]
DR Ensembl; ENST00000622904.4; ENSP00000480444.1; ENSG00000275136.4. [P24071-11]
DR Ensembl; ENST00000638206.1; ENSP00000492749.1; ENSG00000284061.2. [P24071-3]
DR Ensembl; ENST00000638212.2; ENSP00000492230.1; ENSG00000284061.2. [P24071-1]
DR Ensembl; ENST00000638244.1; ENSP00000492699.1; ENSG00000283953.2. [P24071-7]
DR Ensembl; ENST00000638285.1; ENSP00000491595.1; ENSG00000284061.2. [P24071-8]
DR Ensembl; ENST00000638453.1; ENSP00000491493.1; ENSG00000284061.2. [P24071-4]
DR Ensembl; ENST00000638527.1; ENSP00000491362.1; ENSG00000284245.2. [P24071-2]
DR Ensembl; ENST00000638553.1; ENSP00000491372.1; ENSG00000284004.2. [P24071-7]
DR Ensembl; ENST00000638625.1; ENSP00000492755.1; ENSG00000283953.2. [P24071-9]
DR Ensembl; ENST00000638882.1; ENSP00000492226.1; ENSG00000283953.2. [P24071-3]
DR Ensembl; ENST00000638900.1; ENSP00000491778.1; ENSG00000283953.2. [P24071-8]
DR Ensembl; ENST00000638945.1; ENSP00000492228.1; ENSG00000284245.2. [P24071-9]
DR Ensembl; ENST00000638966.1; ENSP00000491307.1; ENSG00000283953.2. [P24071-11]
DR Ensembl; ENST00000638995.1; ENSP00000491741.1; ENSG00000284004.2. [P24071-3]
DR Ensembl; ENST00000639014.1; ENSP00000491039.1; ENSG00000284245.2. [P24071-8]
DR Ensembl; ENST00000639163.1; ENSP00000491556.1; ENSG00000284061.2. [P24071-7]
DR Ensembl; ENST00000639178.1; ENSP00000492137.1; ENSG00000284061.2. [P24071-2]
DR Ensembl; ENST00000639193.1; ENSP00000491447.1; ENSG00000284004.2. [P24071-2]
DR Ensembl; ENST00000639223.1; ENSP00000492274.1; ENSG00000284061.2. [P24071-10]
DR Ensembl; ENST00000639402.2; ENSP00000492442.1; ENSG00000284245.2. [P24071-1]
DR Ensembl; ENST00000639426.1; ENSP00000492415.1; ENSG00000284004.2. [P24071-10]
DR Ensembl; ENST00000639428.1; ENSP00000491642.1; ENSG00000284061.2. [P24071-11]
DR Ensembl; ENST00000639455.1; ENSP00000491849.1; ENSG00000284061.2. [P24071-9]
DR Ensembl; ENST00000639575.1; ENSP00000492321.1; ENSG00000283953.2. [P24071-2]
DR Ensembl; ENST00000639763.1; ENSP00000491420.1; ENSG00000284004.2. [P24071-8]
DR Ensembl; ENST00000640025.2; ENSP00000492529.2; ENSG00000283750.3. [P24071-1]
DR Ensembl; ENST00000640032.1; ENSP00000492077.1; ENSG00000284004.2. [P24071-9]
DR Ensembl; ENST00000640047.1; ENSP00000490997.1; ENSG00000284245.2. [P24071-7]
DR Ensembl; ENST00000640063.1; ENSP00000491889.1; ENSG00000284004.2. [P24071-11]
DR Ensembl; ENST00000640239.2; ENSP00000492762.1; ENSG00000283953.2. [P24071-1]
DR Ensembl; ENST00000640405.2; ENSP00000491490.1; ENSG00000284004.2. [P24071-1]
DR Ensembl; ENST00000640415.1; ENSP00000491274.1; ENSG00000284245.2. [P24071-10]
DR Ensembl; ENST00000640430.1; ENSP00000492494.1; ENSG00000283953.2. [P24071-4]
DR Ensembl; ENST00000640462.1; ENSP00000491298.1; ENSG00000284245.2. [P24071-3]
DR Ensembl; ENST00000640582.2; ENSP00000492447.1; ENSG00000283750.3. [P24071-1]
DR Ensembl; ENST00000640584.1; ENSP00000491818.1; ENSG00000284061.2. [P24071-5]
DR Ensembl; ENST00000640618.1; ENSP00000491815.1; ENSG00000284245.2. [P24071-5]
DR Ensembl; ENST00000640687.1; ENSP00000492597.1; ENSG00000283953.2. [P24071-5]
DR Ensembl; ENST00000640761.1; ENSP00000492411.1; ENSG00000284004.2. [P24071-4]
DR Ensembl; ENST00000640811.1; ENSP00000492678.1; ENSG00000283953.2. [P24071-10]
DR Ensembl; ENST00000640878.1; ENSP00000492686.1; ENSG00000284245.2. [P24071-11]
DR Ensembl; ENST00000640908.1; ENSP00000492162.1; ENSG00000284245.2. [P24071-4]
DR Ensembl; ENST00000640918.1; ENSP00000491746.1; ENSG00000284004.2. [P24071-5]
DR GeneID; 2204; -.
DR KEGG; hsa:2204; -.
DR MANE-Select; ENST00000355524.8; ENSP00000347714.3; NM_002000.4; NP_001991.1.
DR UCSC; uc002qhq.4; human. [P24071-1]
DR CTD; 2204; -.
DR DisGeNET; 2204; -.
DR GeneCards; FCAR; -.
DR HGNC; HGNC:3608; FCAR.
DR HPA; ENSG00000186431; Group enriched (bone marrow, lung, lymphoid tissue).
DR MIM; 147045; gene.
DR neXtProt; NX_P24071; -.
DR OpenTargets; ENSG00000186431; -.
DR PharmGKB; PA28055; -.
DR VEuPathDB; HostDB:ENSG00000186431; -.
DR eggNOG; ENOG502RCU0; Eukaryota.
DR GeneTree; ENSGT01000000214458; -.
DR HOGENOM; CLU_021100_1_3_1; -.
DR InParanoid; P24071; -.
DR OMA; GSVKILC; -.
DR OrthoDB; 1327293at2759; -.
DR PhylomeDB; P24071; -.
DR TreeFam; TF336644; -.
DR PathwayCommons; P24071; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; P24071; -.
DR SIGNOR; P24071; -.
DR BioGRID-ORCS; 2204; 8 hits in 1061 CRISPR screens.
DR ChiTaRS; FCAR; human.
DR EvolutionaryTrace; P24071; -.
DR GeneWiki; FCAR; -.
DR GenomeRNAi; 2204; -.
DR Pharos; P24071; Tbio.
DR PRO; PR:P24071; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P24071; protein.
DR Bgee; ENSG00000186431; Expressed in monocyte and 91 other tissues.
DR ExpressionAtlas; P24071; baseline and differential.
DR Genevisible; P24071; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0101003; C:ficolin-1-rich granule membrane; TAS:Reactome.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:CAFA.
DR GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
DR GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
DR GO; GO:0019862; F:IgA binding; IDA:CAFA.
DR GO; GO:0019766; F:IgA receptor activity; IDA:CAFA.
DR GO; GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:CAFA.
DR GO; GO:0035457; P:cellular response to interferon-alpha; IDA:CAFA.
DR GO; GO:0071346; P:cellular response to interferon-gamma; IDA:CAFA.
DR GO; GO:0071354; P:cellular response to interleukin-6; IDA:CAFA.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IDA:CAFA.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IDA:CAFA.
DR GO; GO:0038093; P:Fc receptor signaling pathway; IDA:CAFA.
DR GO; GO:0006955; P:immune response; TAS:ProtInc.
DR GO; GO:0042119; P:neutrophil activation; IDA:CAFA.
DR GO; GO:0002446; P:neutrophil mediated immunity; IDA:CAFA.
DR GO; GO:0033031; P:positive regulation of neutrophil apoptotic process; IDA:CAFA.
DR GO; GO:1903209; P:positive regulation of oxidative stress-induced cell death; IDA:CAFA.
DR DisProt; DP00311; -.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell membrane; Disulfide bond;
KW Glycoprotein; IgA-binding protein; Immunoglobulin domain; Membrane;
KW Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..287
FT /note="Immunoglobulin alpha Fc receptor"
FT /id="PRO_0000015138"
FT TOPO_DOM 22..227
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..107
FT /note="Ig-like C2-type 1"
FT DOMAIN 139..200
FT /note="Ig-like C2-type 2"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12768205"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12768205"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..100
FT /evidence="ECO:0000269|PubMed:12768205,
FT ECO:0000269|PubMed:12783876, ECO:0007744|PDB:1OVZ,
FT ECO:0007744|PDB:1OW0, ECO:0007744|PDB:1UCT"
FT DISULFID 146..193
FT /evidence="ECO:0000269|PubMed:12768205,
FT ECO:0000269|PubMed:12783876, ECO:0007744|PDB:1OVZ,
FT ECO:0007744|PDB:1OW0, ECO:0007744|PDB:1UCT"
FT VAR_SEQ 12..23
FT /note="Missing (in isoform B-delta-S2, isoform L10, isoform
FT U09, isoform U10, isoform U11 and isoform U13)"
FT /evidence="ECO:0000303|PubMed:9367406"
FT /id="VSP_002632"
FT VAR_SEQ 24..120
FT /note="Missing (in isoform L10)"
FT /evidence="ECO:0000303|PubMed:9367406"
FT /id="VSP_043565"
FT VAR_SEQ 24
FT /note="G -> GRYISEHFWCRSLGCNPVNDASAQRPG (in isoform U02)"
FT /evidence="ECO:0000303|PubMed:9367406"
FT /id="VSP_002633"
FT VAR_SEQ 115..210
FT /note="Missing (in isoform U10)"
FT /evidence="ECO:0000303|PubMed:9367406"
FT /id="VSP_043566"
FT VAR_SEQ 121..216
FT /note="Missing (in isoform A.3)"
FT /evidence="ECO:0000303|PubMed:8666819,
FT ECO:0000303|PubMed:8836118, ECO:0000303|PubMed:9367406"
FT /id="VSP_002634"
FT VAR_SEQ 193..287
FT /note="CYGWYNRSPYLWSFPSNALELVVTDSIHQDYTTQNLIRMAVAGLVLVALLAI
FT LVENWHSHTALNKEASADVAEPSWSQQMCQPGLTFARTPSVCK -> LHPPRLHDAELD
FT PHGRGRTGPRGSLGHTG (in isoform U09)"
FT /evidence="ECO:0000303|PubMed:9367406"
FT /id="VSP_043567"
FT VAR_SEQ 195..216
FT /note="Missing (in isoform A.2, isoform U02 and isoform
FT U13)"
FT /evidence="ECO:0000303|PubMed:8666819,
FT ECO:0000303|PubMed:9367406"
FT /id="VSP_002635"
FT VAR_SEQ 217..287
FT /note="DSIHQDYTTQNLIRMAVAGLVLVALLAILVENWHSHTALNKEASADVAEPSW
FT SQQMCQPGLTFARTPSVCK -> GRYRPVQPCVWVGCPGPCHRAGI (in isoform
FT B and isoform B-delta-S2)"
FT /evidence="ECO:0000305"
FT /id="VSP_002636"
FT VARIANT 113
FT /note="D -> N (in dbSNP:rs11666735)"
FT /evidence="ECO:0000269|PubMed:17548632"
FT /id="VAR_049996"
FT VARIANT 269
FT /note="S -> G (in dbSNP:rs16986050)"
FT /evidence="ECO:0000269|PubMed:17548632"
FT /id="VAR_049997"
FT HELIX 23..25
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 31..35
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 37..40
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 45..49
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 56..64
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 67..70
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 72..74
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:1OVZ"
FT STRAND 84..87
FT /evidence="ECO:0007829|PDB:1UCT"
FT HELIX 92..94
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 96..104
FT /evidence="ECO:0007829|PDB:1UCT"
FT TURN 105..107
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 108..111
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 115..120
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 127..132
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 134..136
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 143..147
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 149..151
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 154..160
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 168..171
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 173..179
FT /evidence="ECO:0007829|PDB:1UCT"
FT HELIX 185..187
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 189..196
FT /evidence="ECO:0007829|PDB:1UCT"
FT STRAND 198..200
FT /evidence="ECO:0007829|PDB:1OVZ"
FT STRAND 211..215
FT /evidence="ECO:0007829|PDB:1UCT"
SQ SEQUENCE 287 AA; 32265 MW; A2CCA68467CD45F7 CRC64;
MDPKQTTLLC LVLCLGQRIQ AQEGDFPMPF ISAKSSPVIP LDGSVKIQCQ AIREAYLTQL
MIIKNSTYRE IGRRLKFWNE TDPEFVIDHM DANKAGRYQC QYRIGHYRFR YSDTLELVVT
GLYGKPFLSA DRGLVLMPGE NISLTCSSAH IPFDRFSLAK EGELSLPQHQ SGEHPANFSL
GPVDLNVSGI YRCYGWYNRS PYLWSFPSNA LELVVTDSIH QDYTTQNLIR MAVAGLVLVA
LLAILVENWH SHTALNKEAS ADVAEPSWSQ QMCQPGLTFA RTPSVCK
