FCER2_MOUSE
ID FCER2_MOUSE Reviewed; 331 AA.
AC P20693; Q61556; Q61557;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Low affinity immunoglobulin epsilon Fc receptor;
DE AltName: Full=Fc-epsilon-RII;
DE AltName: Full=Lymphocyte IgE receptor;
DE AltName: CD_antigen=CD23;
GN Name=Fcer2; Synonyms=Fcer2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2529542; DOI=10.1073/pnas.86.19.7566;
RA Bettler B., Hofstetter H., Rao M., Yokoyama W.M., Kilchherr F.,
RA Conrad D.H.;
RT "Molecular structure and expression of the murine lymphocyte low-affinity
RT receptor for IgE (Fc epsilon RII).";
RL Proc. Natl. Acad. Sci. U.S.A. 86:7566-7570(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2137845;
RA Gollnick S.O., Trounstine M.L., Yamashita L.C., Kehry M.R., Moore K.W.;
RT "Isolation, characterization, and expression of cDNA clones encoding the
RT mouse Fc receptor for IgE (Fc epsilon RII)1.";
RL J. Immunol. 144:1974-1982(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=DBA/2J;
RX PubMed=8086828; DOI=10.1159/000236801;
RA Kondo H., Ichikawa Y., Nakamura K., Tsuchiya S.;
RT "Cloning of cDNAs for new subtypes of murine low-affinity Fc receptor for
RT IgE (Fc epsilon RII/CD23).";
RL Int. Arch. Allergy Immunol. 105:38-48(1994).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP 3D-STRUCTURE MODELING OF LECTIN DOMAIN.
RX PubMed=8142907;
RA Padlan E.A., Helm B.A.;
RT "Modeling of the lectin-homology domains of the human and murine low-
RT affinity Fc epsilon receptor (Fc epsilon RII/CD23).";
RL Receptor 3:325-341(1993).
CC -!- FUNCTION: Low-affinity receptor for immunoglobulin E (IgE) and
CC CR2/CD21. Has essential roles in the regulation of IgE production and
CC in the differentiation of B-cells (it is a B-cell-specific antigen).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-
CC anchor {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=A;
CC IsoId=P20693-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=P20693-2; Sequence=VSP_003058;
CC Name=3; Synonyms=C;
CC IsoId=P20693-3; Sequence=VSP_003059;
CC -!- PTM: N- and O-glycosylated. {ECO:0000250}.
CC -!- MISCELLANEOUS: There are two kinds of Fc receptors for IgE, which
CC differ in both structure and function: high affinity receptors on
CC basophils and mast cells and low affinity receptors on lymphocytes and
CC monocytes.
CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC Note=CD23;
CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_222";
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DR EMBL; M99371; AAA74898.1; -; mRNA.
DR EMBL; M34163; AAA37603.1; -; mRNA.
DR EMBL; X64223; CAA45532.1; -; mRNA.
DR EMBL; X64224; CAA45533.1; -; mRNA.
DR CCDS; CCDS22071.1; -. [P20693-1]
DR CCDS; CCDS85491.1; -. [P20693-3]
DR CCDS; CCDS85494.1; -. [P20693-2]
DR PIR; A43518; LNMSER.
DR RefSeq; NP_001240666.1; NM_001253737.1. [P20693-2]
DR RefSeq; NP_001240668.1; NM_001253739.1. [P20693-3]
DR RefSeq; NP_001240672.1; NM_001253743.1.
DR RefSeq; NP_001240674.1; NM_001253745.1.
DR RefSeq; NP_001240675.1; NM_001253746.1.
DR RefSeq; NP_001240676.1; NM_001253747.1.
DR RefSeq; NP_038545.1; NM_013517.4. [P20693-1]
DR AlphaFoldDB; P20693; -.
DR SMR; P20693; -.
DR STRING; 10090.ENSMUSP00000005678; -.
DR GlyGen; P20693; 2 sites.
DR iPTMnet; P20693; -.
DR PhosphoSitePlus; P20693; -.
DR EPD; P20693; -.
DR PaxDb; P20693; -.
DR PRIDE; P20693; -.
DR ProteomicsDB; 271728; -. [P20693-1]
DR ProteomicsDB; 271730; -. [P20693-3]
DR Antibodypedia; 2294; 1713 antibodies from 50 providers.
DR DNASU; 14128; -.
DR Ensembl; ENSMUST00000005678; ENSMUSP00000005678; ENSMUSG00000005540. [P20693-1]
DR Ensembl; ENSMUST00000208145; ENSMUSP00000146647; ENSMUSG00000005540. [P20693-3]
DR Ensembl; ENSMUST00000208492; ENSMUSP00000146568; ENSMUSG00000005540. [P20693-2]
DR GeneID; 14128; -.
DR KEGG; mmu:14128; -.
DR UCSC; uc009ksl.1; mouse. [P20693-3]
DR UCSC; uc009ksm.1; mouse. [P20693-2]
DR UCSC; uc009ksn.1; mouse. [P20693-1]
DR CTD; 14128; -.
DR MGI; MGI:95497; Fcer2a.
DR VEuPathDB; HostDB:ENSMUSG00000005540; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000162574; -.
DR HOGENOM; CLU_049894_7_2_1; -.
DR InParanoid; P20693; -.
DR OMA; TCNTCPE; -.
DR OrthoDB; 985894at2759; -.
DR PhylomeDB; P20693; -.
DR TreeFam; TF333341; -.
DR BioGRID-ORCS; 14128; 2 hits in 72 CRISPR screens.
DR PRO; PR:P20693; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P20693; protein.
DR Bgee; ENSMUSG00000005540; Expressed in peripheral lymph node and 42 other tissues.
DR ExpressionAtlas; P20693; baseline and differential.
DR Genevisible; P20693; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0030246; F:carbohydrate binding; IBA:GO_Central.
DR GO; GO:0019863; F:IgE binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002925; P:positive regulation of humoral immune response mediated by circulating immunoglobulin; IMP:MGI.
DR GO; GO:0051712; P:positive regulation of killing of cells of another organism; ISO:MGI.
DR GO; GO:0051000; P:positive regulation of nitric-oxide synthase activity; ISO:MGI.
DR GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; ISO:MGI.
DR CDD; cd03590; CLECT_DC-SIGN_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR018378; C-type_lectin_CS.
DR InterPro; IPR033989; CD209-like_CTLD.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Cell membrane; Disulfide bond; Glycoprotein;
KW IgE-binding protein; Lectin; Lipoprotein; Membrane; Metal-binding;
KW Palmitate; Receptor; Reference proteome; Repeat; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..331
FT /note="Low affinity immunoglobulin epsilon Fc receptor"
FT /id="PRO_0000046640"
FT TOPO_DOM 1..23
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..49
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..331
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REPEAT 71..91
FT REPEAT 92..112
FT REPEAT 113..133
FT DOMAIN 185..298
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT BINDING 272
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 292
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT BINDING 293
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000250"
FT LIPID 17
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 18
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 183..311
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 186..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 214..305
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 282..296
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VAR_SEQ 1..7
FT /note="MEENEYS -> MNSQNQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8086828"
FT /id="VSP_003058"
FT VAR_SEQ 1..7
FT /note="MEENEYS -> MDTHHT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:8086828"
FT /id="VSP_003059"
SQ SEQUENCE 331 AA; 37648 MW; B8C6D65F34ACCDB2 CRC64;
MEENEYSGYW EPPRKRCCCA RRGTQLMLVG LLSTAMWAGL LALLLLWHWE TEKNLKQLGD
TAIQNVSHVT KDLQKFQSNQ LAQKSQVVQM SQNLQELQAE QKQMKAQDSR LSQNLTGLQE
DLRNAQSQNS KLSQNLNRLQ DDLVNIKSLG LNEKRTASDS LEKLQEEVAK LWIEILISKG
TACNICPKNW LHFQQKCYYF GKGSKQWIQA RFACSDLQGR LVSIHSQKEQ DFLMQHINKK
DSWIGLQDLN MEGEFVWSDG SPVGYSNWNP GEPNNGGQGE DCVMMRGSGQ WNDAFCRSYL
DAWVCEQLAT CEISAPLASV TPTRPTPKSE P
