FCERG_CAVPO
ID FCERG_CAVPO Reviewed; 86 AA.
AC Q07249;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=High affinity immunoglobulin epsilon receptor subunit gamma;
DE AltName: Full=Fc receptor gamma-chain;
DE Short=FcRgamma;
DE AltName: Full=Fc-epsilon RI-gamma;
DE AltName: Full=IgE Fc receptor subunit gamma;
DE Short=FceRI gamma;
DE Flags: Precursor;
GN Name=FCER1G;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Yamashita T.;
RL Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adapter protein containing an immunoreceptor tyrosine-based
CC activation motif (ITAM) that transduces activation signals from various
CC immunoreceptors. As a component of the high-affinity immunoglobulin E
CC (IgE) receptor, mediates allergic inflammatory signaling in mast cells.
CC As a constitutive component of interleukin-3 receptor complex,
CC selectively mediates interleukin 4/IL4 production by basophils priming
CC T-cells toward effector T-helper 2 subset. Associates with pattern
CC recognition receptors CLEC4D and CLEC4E to form a functional signaling
CC complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-
CC dimycolate (TDM) to this receptor complex leads to phosphorylation of
CC ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently
CC driving maturation of antigen-presenting cells and shaping antigen-
CC specific priming of T-cells toward effector T-helper 1 and T-helper 17
CC cell subtypes. May function cooperatively with other activating
CC receptors. Functionally linked to integrin beta-2/ITGB2-mediated
CC neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated
CC platelet activation. {ECO:0000250|UniProtKB:P20491}.
CC -!- SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta chain,
CC and two disulfide linked gamma chains. Associates with FCGR1A; forms a
CC functional signaling complex (By similarity). The signaling subunit of
CC immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a
CC heterodimer of CD247 and FCER1G, associates with the ligand binding
CC subunit FCGR3A to form a functional receptor complex (By similarity).
CC Associates with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM
CC domain) with SYK (via SH2 domains); activates SYK, enabling integrin-
CC mediated activation of neutrophils and macrophages (By similarity).
CC Interacts with CSF2RB and recruits SYK in response to IL3 stimulation;
CC this interaction is direct (By similarity). Interacts with CD300LH; the
CC interaction may be indirect. Interacts with CD300LD (By similarity).
CC Interacts with TARM1 (By similarity). {ECO:0000250|UniProtKB:P20411,
CC ECO:0000250|UniProtKB:P20491, ECO:0000250|UniProtKB:P30273}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD3Z/FCER1G family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D16188; BAA03729.1; -; mRNA.
DR AlphaFoldDB; Q07249; -.
DR SMR; Q07249; -.
DR STRING; 10141.ENSCPOP00000013813; -.
DR eggNOG; ENOG502S7XC; Eukaryota.
DR InParanoid; Q07249; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR GO; GO:0032998; C:Fc-epsilon receptor I complex; IEA:InterPro.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019863; F:IgE binding; IEA:UniProtKB-KW.
DR GO; GO:0019767; F:IgE receptor activity; IEA:InterPro.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; ISS:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0038156; P:interleukin-3-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.
DR GO; GO:0031623; P:receptor internalization; ISS:UniProtKB.
DR InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
DR InterPro; IPR042340; FCER1G.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR PANTHER; PTHR16803; PTHR16803; 1.
DR Pfam; PF02189; ITAM; 1.
DR Pfam; PF11628; TCR_zetazeta; 1.
DR SMART; SM00077; ITAM; 1.
DR PROSITE; PS51055; ITAM_1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; IgE-binding protein; Immunity;
KW Innate immunity; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..86
FT /note="High affinity immunoglobulin epsilon receptor
FT subunit gamma"
FT /id="PRO_0000016500"
FT TOPO_DOM 19..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 54..82
FT /note="ITAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00379"
FT MOD_RES 65
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P20491,
FT ECO:0000255|PROSITE-ProRule:PRU00379"
FT MOD_RES 69
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P30273"
FT MOD_RES 76
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P20491,
FT ECO:0000255|PROSITE-ProRule:PRU00379"
FT MOD_RES 78
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P20491"
FT DISULFID 25
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 86 AA; 9742 MW; 99C873D49C97D45B CRC64;
MYPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIILT LLYCRLKIQV RKATVASYEK
PDGIYTGLST RNQETYETLK HEKPPQ
