FCERG_PIG
ID FCERG_PIG Reviewed; 86 AA.
AC Q9XSZ6;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=High affinity immunoglobulin epsilon receptor subunit gamma;
DE AltName: Full=Fc receptor gamma-chain;
DE Short=FcRgamma;
DE AltName: Full=Fc-epsilon RI-gamma;
DE AltName: Full=IgE Fc receptor subunit gamma;
DE Short=FceRI gamma;
DE Flags: Precursor;
GN Name=FCER1G;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Minnesota miniature;
RA Yim D., Kim Y.B.;
RT "Molecular cloning of porcine Fc epsilon receptor gamma chain.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adapter protein containing an immunoreceptor tyrosine-based
CC activation motif (ITAM) that transduces activation signals from various
CC immunoreceptors. As a component of the high-affinity immunoglobulin E
CC (IgE) receptor, mediates allergic inflammatory signaling in mast cells.
CC As a constitutive component of interleukin-3 receptor complex,
CC selectively mediates interleukin 4/IL4 production b basophils priming
CC T-cells toward effector T-helper 2 subset. Associates with pattern
CC recognition receptors CLEC4D and CLEC4E to form a functional signaling
CC complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-
CC dimycolate (TDM) to this receptor complex leads to phosphorylation of
CC ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently
CC driving maturation of antigen-presenting cells and shaping antigen-
CC specific priming of T-cells toward effector T-helper 1 and T-helper 17
CC cell subtypes. May function cooperatively with other activating
CC receptors. Functionally linked to integrin beta-2/ITGB2-mediated
CC neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated
CC platelet activation. {ECO:0000250|UniProtKB:P20491}.
CC -!- SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta chain,
CC and two disulfide linked gamma chains. Associates with FCGR1A; forms a
CC functional signaling complex (By similarity). The signaling subunit of
CC immunoglobulin gamma (IgG) Fc receptor complex. As a homodimer or a
CC heterodimer of CD247 and FCER1G, associates with the ligand binding
CC subunit FCGR3A to form a functional receptor complex (By similarity).
CC Associates with CLEC6A. Interacts with CLEC4E. Interacts (via ITAM
CC domain) with SYK (via SH2 domains); activates SYK, enabling integrin-
CC mediated activation of neutrophils and macrophages (By similarity).
CC Interacts with common beta chain of interleukin 3 receptor CSF2RB and
CC recruits SYK in response to IL3 stimulation; this interaction is direct
CC (By similarity). Interacts with CD300LH; the interaction may be
CC indirect. Interacts with CD300LD (By similarity). Interacts with TARM1
CC (By similarity). {ECO:0000250|UniProtKB:P20411,
CC ECO:0000250|UniProtKB:P20491, ECO:0000250|UniProtKB:P30273}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD3Z/FCER1G family. {ECO:0000305}.
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DR EMBL; AF148221; AAD38022.1; -; mRNA.
DR RefSeq; NP_001001265.1; NM_001001265.1.
DR AlphaFoldDB; Q9XSZ6; -.
DR SMR; Q9XSZ6; -.
DR PaxDb; Q9XSZ6; -.
DR PeptideAtlas; Q9XSZ6; -.
DR PRIDE; Q9XSZ6; -.
DR Ensembl; ENSSSCT00070052023; ENSSSCP00070044016; ENSSSCG00070025990.
DR GeneID; 397406; -.
DR KEGG; ssc:397406; -.
DR CTD; 2207; -.
DR eggNOG; ENOG502S7XC; Eukaryota.
DR HOGENOM; CLU_192374_0_0_1; -.
DR InParanoid; Q9XSZ6; -.
DR OMA; CRLKIQM; -.
DR OrthoDB; 1577383at2759; -.
DR TreeFam; TF330937; -.
DR Reactome; R-SSC-114604; GPVI-mediated activation cascade.
DR Reactome; R-SSC-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-SSC-2454202; Fc epsilon receptor (FCERI) signaling.
DR Reactome; R-SSC-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-SSC-2871796; FCERI mediated MAPK activation.
DR Reactome; R-SSC-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-SSC-2871837; FCERI mediated NF-kB activation.
DR Reactome; R-SSC-5621480; Dectin-2 family.
DR Reactome; R-SSC-6798695; Neutrophil degranulation.
DR Reactome; R-SSC-75892; Platelet Adhesion to exposed collagen.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 4.
DR Genevisible; Q9XSZ6; SS.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0032998; C:Fc-epsilon receptor I complex; IBA:GO_Central.
DR GO; GO:0033001; C:Fc-gamma receptor III complex; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0019863; F:IgE binding; IEA:UniProtKB-KW.
DR GO; GO:0019767; F:IgE receptor activity; IBA:GO_Central.
DR GO; GO:0019864; F:IgG binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; IBA:GO_Central.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0071404; P:cellular response to low-density lipoprotein particle stimulus; ISS:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR GO; GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IBA:GO_Central.
DR GO; GO:0038094; P:Fc-gamma receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0016064; P:immunoglobulin mediated immune response; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0038156; P:interleukin-3-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0002283; P:neutrophil activation involved in immune response; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.
DR GO; GO:0050766; P:positive regulation of phagocytosis; IBA:GO_Central.
DR GO; GO:0031623; P:receptor internalization; ISS:UniProtKB.
DR GO; GO:0010543; P:regulation of platelet activation; IBA:GO_Central.
DR GO; GO:0002292; P:T cell differentiation involved in immune response; IBA:GO_Central.
DR InterPro; IPR021663; CD3_zeta/IgE_Fc_rcpt_gamma.
DR InterPro; IPR042340; FCER1G.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR PANTHER; PTHR16803; PTHR16803; 1.
DR Pfam; PF02189; ITAM; 1.
DR Pfam; PF11628; TCR_zetazeta; 1.
DR SMART; SM00077; ITAM; 1.
DR PROSITE; PS51055; ITAM_1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; IgE-binding protein; Immunity;
KW Innate immunity; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..86
FT /note="High affinity immunoglobulin epsilon receptor
FT subunit gamma"
FT /id="PRO_0000016504"
FT TOPO_DOM 19..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 54..82
FT /note="ITAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00379"
FT MOD_RES 65
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P20491,
FT ECO:0000255|PROSITE-ProRule:PRU00379"
FT MOD_RES 69
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P30273"
FT MOD_RES 76
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P20491,
FT ECO:0000255|PROSITE-ProRule:PRU00379"
FT MOD_RES 78
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P20491"
FT DISULFID 25
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 86 AA; 9681 MW; 756D7536513D7763 CRC64;
MIPAVVLLLL LLVEQAAALG EPQLCYILDA ILFLYGIVLT LLYCRLKLQV RKAAIDSYEK
SDGVYTGLST RNQETYETLK HEKPPQ
