ID   FCF1_DICDI              Reviewed;         194 AA.
AC   Q55GM5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=rRNA-processing protein FCF1 homolog;
GN   Name=fcf1; ORFNames=DDB_G0267606;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Essential protein involved in pre-rRNA processing and 40S
CC       ribosomal subunit assembly. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73256.1; -; Genomic_DNA.
DR   RefSeq; XP_647159.1; XM_642067.1.
DR   AlphaFoldDB; Q55GM5; -.
DR   SMR; Q55GM5; -.
DR   STRING; 44689.DDB0237574; -.
DR   PaxDb; Q55GM5; -.
DR   EnsemblProtists; EAL73256; EAL73256; DDB_G0267606.
DR   GeneID; 8615962; -.
DR   KEGG; ddi:DDB_G0267606; -.
DR   dictyBase; DDB_G0267606; fcf1.
DR   eggNOG; KOG3165; Eukaryota.
DR   HOGENOM; CLU_081098_0_1_1; -.
DR   InParanoid; Q55GM5; -.
DR   OMA; PLITDCV; -.
DR   PhylomeDB; Q55GM5; -.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q55GM5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd09864; PIN_Fcf1-like; 1.
DR   InterPro; IPR006984; Fcf1/Utp23.
DR   InterPro; IPR037503; Fcf1_PIN.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   Pfam; PF04900; Fcf1; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..194
FT                   /note="rRNA-processing protein FCF1 homolog"
FT                   /id="PRO_0000328283"
FT   DOMAIN          67..166
FT                   /note="PINc"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   194 AA;  22588 MW;  554691704167B870 CRC64;
     MARKPGLAPK KVPLQKLNKT NPNFSNRQKQ IQRSKQEDEH RKKLEEIPED NTSHMFFSYN
     EALVPPYHVI IDTNFINFSI SHKLDIIHSL MDCLYAKCIP YISDCVAAEI ERLGSKFKVA
     LKISKDPRFQ RLTCSHKGTY ADDCIINRIT MHRMFIVATC DADLRRRIRK IPGVPIVYLK
     GKKYTVERMP DLLQ