FCF1_HUMAN
ID FCF1_HUMAN Reviewed; 198 AA.
AC Q9Y324; Q86TW8; Q8TBL8;
DT 09-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=rRNA-processing protein FCF1 homolog;
GN Name=FCF1; Synonyms=C14orf111; ORFNames=CGI-35;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=10810093; DOI=10.1101/gr.10.5.703;
RA Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.;
RT "Identification of novel human genes evolutionarily conserved in
RT Caenorhabditis elegans by comparative proteomics.";
RL Genome Res. 10:703-713(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
CC -!- FUNCTION: Essential protein involved in pre-rRNA processing and 40S
CC ribosomal subunit assembly. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9Y324; Q9P287: BCCIP; NbExp=3; IntAct=EBI-5455734, EBI-711154;
CC Q9Y324; Q5MJ68: SPDYC; NbExp=3; IntAct=EBI-5455734, EBI-12162209;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD62599.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF132969; AAD27744.1; -; mRNA.
DR EMBL; BX248271; CAD62599.1; ALT_INIT; mRNA.
DR EMBL; AC007956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS9832.1; -.
DR RefSeq; NP_057046.1; NM_015962.4.
DR PDB; 7MQ8; EM; 3.60 A; SL=1-198.
DR PDB; 7MQ9; EM; 3.87 A; SL=1-198.
DR PDB; 7MQA; EM; 2.70 A; SL=1-198.
DR PDBsum; 7MQ8; -.
DR PDBsum; 7MQ9; -.
DR PDBsum; 7MQA; -.
DR AlphaFoldDB; Q9Y324; -.
DR SMR; Q9Y324; -.
DR BioGRID; 119268; 94.
DR IntAct; Q9Y324; 58.
DR STRING; 9606.ENSP00000344393; -.
DR iPTMnet; Q9Y324; -.
DR PhosphoSitePlus; Q9Y324; -.
DR SwissPalm; Q9Y324; -.
DR BioMuta; FCF1; -.
DR DMDM; 34582346; -.
DR EPD; Q9Y324; -.
DR jPOST; Q9Y324; -.
DR MassIVE; Q9Y324; -.
DR MaxQB; Q9Y324; -.
DR PaxDb; Q9Y324; -.
DR PeptideAtlas; Q9Y324; -.
DR PRIDE; Q9Y324; -.
DR ProteomicsDB; 85964; -.
DR Antibodypedia; 50547; 16 antibodies from 9 providers.
DR DNASU; 51077; -.
DR Ensembl; ENST00000341162.8; ENSP00000344393.4; ENSG00000119616.11.
DR GeneID; 51077; -.
DR KEGG; hsa:51077; -.
DR MANE-Select; ENST00000341162.8; ENSP00000344393.4; NM_015962.5; NP_057046.1.
DR UCSC; uc001xqh.4; human.
DR CTD; 51077; -.
DR DisGeNET; 51077; -.
DR GeneCards; FCF1; -.
DR HGNC; HGNC:20220; FCF1.
DR HPA; ENSG00000119616; Low tissue specificity.
DR neXtProt; NX_Q9Y324; -.
DR OpenTargets; ENSG00000119616; -.
DR PharmGKB; PA162388159; -.
DR VEuPathDB; HostDB:ENSG00000119616; -.
DR eggNOG; KOG3165; Eukaryota.
DR GeneTree; ENSGT00940000153117; -.
DR InParanoid; Q9Y324; -.
DR OMA; PLITDCV; -.
DR OrthoDB; 1338131at2759; -.
DR PhylomeDB; Q9Y324; -.
DR TreeFam; TF314992; -.
DR PathwayCommons; Q9Y324; -.
DR Reactome; R-HSA-6790901; rRNA modification in the nucleus and cytosol.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR SignaLink; Q9Y324; -.
DR BioGRID-ORCS; 51077; 724 hits in 1052 CRISPR screens.
DR ChiTaRS; FCF1; human.
DR GeneWiki; FCF1; -.
DR GenomeRNAi; 51077; -.
DR Pharos; Q9Y324; Tdark.
DR PRO; PR:Q9Y324; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9Y324; protein.
DR Bgee; ENSG00000119616; Expressed in germinal epithelium of ovary and 203 other tissues.
DR ExpressionAtlas; Q9Y324; baseline and differential.
DR Genevisible; Q9Y324; HS.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR CDD; cd09864; PIN_Fcf1-like; 1.
DR InterPro; IPR006984; Fcf1/Utp23.
DR InterPro; IPR037503; Fcf1_PIN.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR Pfam; PF04900; Fcf1; 1.
DR SMART; SM00670; PINc; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..198
FT /note="rRNA-processing protein FCF1 homolog"
FT /id="PRO_0000089920"
FT DOMAIN 67..166
FT /note="PINc"
FT REGION 22..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 23370 MW; A0C98414C21F16AE CRC64;
MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ HPSCLFFQYN
TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP CITDCVMAEI EKLGQKYRVA
LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT QHKCYIVATV DRDLKRRIRK IPGVPIMYIS
NHRYNIERMP DDYGAPRF
