ID   FCF1_PONAB              Reviewed;         198 AA.
AC   Q5RFQ0;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=rRNA-processing protein FCF1 homolog;
GN   Name=FCF1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential protein involved in pre-rRNA processing and 40S
CC       ribosomal subunit assembly. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CR857102; CAH89407.1; -; mRNA.
DR   RefSeq; NP_001124593.1; NM_001131121.1.
DR   AlphaFoldDB; Q5RFQ0; -.
DR   SMR; Q5RFQ0; -.
DR   STRING; 9601.ENSPPYP00000006810; -.
DR   Ensembl; ENSPPYT00000007079; ENSPPYP00000006810; ENSPPYG00000005991.
DR   GeneID; 100171429; -.
DR   KEGG; pon:100171429; -.
DR   CTD; 51077; -.
DR   eggNOG; KOG3165; Eukaryota.
DR   GeneTree; ENSGT00940000153117; -.
DR   HOGENOM; CLU_081098_0_1_1; -.
DR   InParanoid; Q5RFQ0; -.
DR   OrthoDB; 1338131at2759; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:Ensembl.
DR   CDD; cd09864; PIN_Fcf1-like; 1.
DR   InterPro; IPR006984; Fcf1/Utp23.
DR   InterPro; IPR037503; Fcf1_PIN.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   Pfam; PF04900; Fcf1; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF88723; SSF88723; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..198
FT                   /note="rRNA-processing protein FCF1 homolog"
FT                   /id="PRO_0000089922"
FT   DOMAIN          67..166
FT                   /note="PINc"
FT   REGION          22..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   198 AA;  23370 MW;  A0C98414C21F16AE CRC64;
     MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ HPSCLFFQYN
     TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP CITDCVMAEI EKLGQKYRVA
     LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT QHKCYIVATV DRDLKRRIRK IPGVPIMYIS
     NHRYNIERMP DDYGAPRF