ID   FCF2_SCHPO              Reviewed;         230 AA.
AC   O42877;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=rRNA-processing protein fcf2;
GN   Name=fcf2; ORFNames=SPAC3G9.15c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in pre-rRNA processing and 40S ribosomal subunit
CC       assembly. Required for the early cleavage steps of 35S rRNA at the
CC       A(0), A(1), and A(2) sites (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the FCF2 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA15924.1; -; Genomic_DNA.
DR   PIR; T11651; T11651.
DR   RefSeq; NP_594087.3; NM_001019498.2.
DR   AlphaFoldDB; O42877; -.
DR   SMR; O42877; -.
DR   BioGRID; 279678; 40.
DR   STRING; 4896.SPAC3G9.15c.1; -.
DR   MaxQB; O42877; -.
DR   PaxDb; O42877; -.
DR   PRIDE; O42877; -.
DR   EnsemblFungi; SPAC3G9.15c.1; SPAC3G9.15c.1:pep; SPAC3G9.15c.
DR   GeneID; 2543250; -.
DR   KEGG; spo:SPAC3G9.15c; -.
DR   PomBase; SPAC3G9.15c; fcf2.
DR   VEuPathDB; FungiDB:SPAC3G9.15c; -.
DR   eggNOG; KOG3100; Eukaryota.
DR   HOGENOM; CLU_075129_1_0_1; -.
DR   InParanoid; O42877; -.
DR   OMA; PKRHYRR; -.
DR   PhylomeDB; O42877; -.
DR   PRO; PR:O42877; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   InterPro; IPR039883; Fcf2/DNTTIP2.
DR   InterPro; IPR014810; Fcf2_C.
DR   PANTHER; PTHR21686; PTHR21686; 1.
DR   Pfam; PF08698; Fcf2; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..230
FT                   /note="rRNA-processing protein fcf2"
FT                   /id="PRO_0000374004"
FT   REGION          209..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..230
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   230 AA;  26678 MW;  5750DF6CBA048F19 CRC64;
     MTEIGLSVDL ATISKLLESA KSTLQEKQAS DDDKHGQQKL LTKIPKIISS SFELPSYFEK
     KFVMGLKKDE LVENSESYIN DASFEPTVPI YESHVSAPGI SKKKKNIKDT AGSNWFDMPA
     TELTESVKRD IQLLKMRNAL DPKRHYRREN TKSMPKYFQV GSIVEGPQDF YSSRIPTRER
     KETIVDELLH DSERRSYFKK KYLELQKSKM SGRKGQYKKL QQRRKPSYLK