FCGR3_RAT
ID FCGR3_RAT Reviewed; 267 AA.
AC P27645; Q04798; Q63204;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Low affinity immunoglobulin gamma Fc region receptor III;
DE Short=IgG Fc receptor III;
DE AltName: Full=Fc-gamma RIII;
DE Short=FcRIII;
DE AltName: CD_antigen=CD16;
DE Flags: Precursor;
GN Name=Fcgr3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS B; C AND D).
RC STRAIN=Sprague-Dawley;
RX PubMed=1710249;
RA Farber D.L., Sears D.W.;
RT "Rat CD16 is defined by a family of class III Fc gamma receptors requiring
RT co-expression of heteroprotein subunits.";
RL J. Immunol. 146:4352-4361(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND FUNCTION.
RC TISSUE=Natural killer cell;
RX PubMed=1692135; DOI=10.1073/pnas.87.9.3425;
RA Zeger D.L., Hogarth P.M., Sears D.W.;
RT "Characterization and expression of an Fc gamma receptor cDNA cloned from
RT rat natural killer cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:3425-3429(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H).
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=8482840;
RA Farber D.L., Giorda R., Nettleton M.Y., Trucco M., Kochan J.P., Sears D.W.;
RT "Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding
RT specificity and fail to associate productively with rat CD3 zeta.";
RL J. Immunol. 150:4364-4375(1993).
CC -!- FUNCTION: Receptor for the Fc region of complexed immunoglobulins gamma
CC (PubMed:1692135). Low affinity receptor which binds to IgG1, IgG2a and
CC IgG2b (By similarity). Mediates neutrophil activation by IgG complexes
CC redundantly with Fcgr4 (By similarity). {ECO:0000250|UniProtKB:P08508,
CC ECO:0000269|PubMed:1692135}.
CC -!- SUBUNIT: May form multisubunit complex with other heteroproteins. This
CC association is required for efficient cell-surface expression. Does not
CC associate with CD3 zeta.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08508};
CC Single-pass type I membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Comment=Additional isoforms seem to exist.;
CC Name=C;
CC IsoId=P27645-1; Sequence=Displayed;
CC Name=A;
CC IsoId=P27645-3; Sequence=Not described;
CC Name=B;
CC IsoId=P27645-4; Sequence=Not described;
CC Name=D;
CC IsoId=P27645-5; Sequence=Not described;
CC Name=E;
CC IsoId=P27645-6; Sequence=Not described;
CC Name=F;
CC IsoId=P27645-7; Sequence=Not described;
CC Name=G;
CC IsoId=P27645-8; Sequence=Not described;
CC Name=H;
CC IsoId=P27645-2; Sequence=VSP_002647;
CC -!- TISSUE SPECIFICITY: Expressed on natural killer cells and macrophages.
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DR EMBL; M64368; AAA42049.1; -; mRNA.
DR EMBL; M64369; AAA42048.1; -; mRNA.
DR EMBL; M64370; AAA42050.1; -; mRNA.
DR EMBL; M32062; AAA41148.1; -; mRNA.
DR EMBL; L08446; AAA41151.1; -; mRNA.
DR PIR; A35902; A35902.
DR PIR; I56110; I56110.
DR PIR; I72882; I72882.
DR RefSeq; NP_001129464.1; NM_001135992.1.
DR RefSeq; NP_446295.2; NM_053843.2.
DR RefSeq; XP_006250365.1; XM_006250303.3.
DR RefSeq; XP_006250367.1; XM_006250305.3.
DR RefSeq; XP_008767970.1; XM_008769748.2.
DR RefSeq; XP_008767989.1; XM_008769767.1. [P27645-1]
DR RefSeq; XP_008767990.1; XM_008769768.2. [P27645-1]
DR RefSeq; XP_008767991.1; XM_008769769.2. [P27645-1]
DR RefSeq; XP_008767993.1; XM_008769771.2. [P27645-1]
DR RefSeq; XP_008767994.1; XM_008769772.2. [P27645-1]
DR RefSeq; XP_008767996.1; XM_008769774.2.
DR RefSeq; XP_008767997.1; XM_008769775.2.
DR RefSeq; XP_008767998.1; XM_008769776.2.
DR RefSeq; XP_017454126.1; XM_017598637.1.
DR AlphaFoldDB; P27645; -.
DR SMR; P27645; -.
DR STRING; 10116.ENSRNOP00000039989; -.
DR GlyGen; P27645; 5 sites.
DR PhosphoSitePlus; P27645; -.
DR PaxDb; P27645; -.
DR PRIDE; P27645; -.
DR Ensembl; ENSRNOT00000047349; ENSRNOP00000039989; ENSRNOG00000046663. [P27645-1]
DR Ensembl; ENSRNOT00000073643; ENSRNOP00000064819; ENSRNOG00000046663. [P27645-1]
DR GeneID; 116591; -.
DR GeneID; 498276; -.
DR KEGG; rno:116591; -.
DR KEGG; rno:498276; -.
DR UCSC; RGD:71069; rat. [P27645-1]
DR CTD; 2212; -.
DR RGD; 71069; Fcgr3.
DR VEuPathDB; HostDB:ENSRNOG00000049422; -.
DR eggNOG; ENOG502SVEW; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR InParanoid; P27645; -.
DR OMA; VIFCLVM; -.
DR OrthoDB; 1246375at2759; -.
DR PhylomeDB; P27645; -.
DR Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR PRO; PR:P27645; -.
DR Proteomes; UP000002494; Chromosome 13.
DR Bgee; ENSRNOG00000049422; Expressed in lung and 19 other tissues.
DR Genevisible; P27645; RN.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0019864; F:IgG binding; ISO:RGD.
DR GO; GO:0019770; F:IgG receptor activity; ISO:RGD.
DR GO; GO:0034987; F:immunoglobulin receptor binding; IDA:RGD.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0001788; P:antibody-dependent cellular cytotoxicity; ISO:RGD.
DR GO; GO:0042590; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; ISO:RGD.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:RGD.
DR GO; GO:0045576; P:mast cell activation; ISO:RGD.
DR GO; GO:0021675; P:nerve development; IEP:RGD.
DR GO; GO:0030593; P:neutrophil chemotaxis; ISO:RGD.
DR GO; GO:0006911; P:phagocytosis, engulfment; ISO:RGD.
DR GO; GO:0006910; P:phagocytosis, recognition; ISO:RGD.
DR GO; GO:0050766; P:positive regulation of phagocytosis; ISO:RGD.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0001812; P:positive regulation of type I hypersensitivity; ISO:RGD.
DR GO; GO:0001798; P:positive regulation of type IIa hypersensitivity; ISO:RGD.
DR GO; GO:0001805; P:positive regulation of type III hypersensitivity; ISO:RGD.
DR GO; GO:0001813; P:regulation of antibody-dependent cellular cytotoxicity; IMP:RGD.
DR GO; GO:1905449; P:regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; IMP:RGD.
DR GO; GO:0050776; P:regulation of immune response; ISO:RGD.
DR GO; GO:0032680; P:regulation of tumor necrosis factor production; IMP:RGD.
DR GO; GO:0001820; P:serotonin secretion; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW IgG-binding protein; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..36
FT /evidence="ECO:0000255"
FT CHAIN 37..267
FT /note="Low affinity immunoglobulin gamma Fc region receptor
FT III"
FT /id="PRO_0000015156"
FT TOPO_DOM 37..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..267
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 39..121
FT /note="Ig-like C2-type 1"
FT DOMAIN 122..204
FT /note="Ig-like C2-type 2"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 78
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 62..104
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 143..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 145..176
FT /note="SWKNKQLTKVLLFQNGKPVRYYYQSSNFSIPK -> GWKSIQLARISFLQNG
FT EFVSFHPYNVSYSISN (in isoform H)"
FT /evidence="ECO:0000303|PubMed:8482840"
FT /id="VSP_002647"
FT VARIANT 36..39
FT /note="ANLP -> GDLL (in isoform A and isoform H)"
FT VARIANT 55
FT /note="E -> D (in isoform A and isoform H)"
FT VARIANT 56
FT /note="D -> G (in isoform D)"
FT VARIANT 115
FT /note="V -> I (in isoform A and isoform B)"
FT VARIANT 134
FT /note="E -> L (in isoform H)"
FT VARIANT 138
FT /note="T -> R (in isoform H)"
FT VARIANT 184
FT /note="N -> D (in isoform H)"
FT VARIANT 195
FT /note="M -> E (in isoform H)"
FT VARIANT 254
FT /note="K -> R (in isoform H)"
SQ SEQUENCE 267 AA; 30282 MW; DD4D6A7A3F70ED92 CRC64;
MTLETQMFQN AHSGSQWLLP PLTMLLLFAF ADRQTANLPK AVVKRDPPWI QVLKEDTVTL
TCEGTHNPGN SSTQWFHNQS STWGQVQASY TFKATVNDSG EYRCRMAHTS LSDPVHLEVI
SDWLLLQTPQ LVFEEGETIT LRCHSWKNKQ LTKVLLFQNG KPVRYYYQSS NFSIPKANHS
HSGNYYCKAY LGRTMHVSKP VTITVQGSAT ASTSSLVWFH AAFCLVMCLL FAVDTGLYFC
VRRNLQTSGE DWRKSLSVGK YKAPQDK
