ID   FCOT_MYCBO              Reviewed;         183 AA.
AC   P64686; A0A1R3XUB7; Q10894; X2BE08;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Long-chain fatty acyl-CoA thioesterase FcoT {ECO:0000250|UniProtKB:P9WM67};
DE            EC=3.1.2.- {ECO:0000250|UniProtKB:P9WM67};
GN   Name=fcoT {ECO:0000250|UniProtKB:P9WM67}; OrderedLocusNames=BQ2027_MB0101;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Thiesterase that shows a preference for long chain fatty acyl
CC       groups. {ECO:0000250|UniProtKB:P9WM67}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+);
CC         Xref=Rhea:RHEA:16781, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:28868, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636;
CC         Evidence={ECO:0000250|UniProtKB:P9WM67};
CC   -!- SIMILARITY: Belongs to the FcoT family. {ECO:0000305}.
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DR   EMBL; LT708304; SIT98505.1; -; Genomic_DNA.
DR   RefSeq; NP_853769.1; NC_002945.3.
DR   RefSeq; WP_003899810.1; NC_002945.4.
DR   AlphaFoldDB; P64686; -.
DR   SMR; P64686; -.
DR   PATRIC; fig|233413.5.peg.113; -.
DR   OMA; SCYIDDT; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0047617; F:acyl-CoA hydrolase activity; IEA:RHEA.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.129.30; -; 1.
DR   InterPro; IPR022598; FcoT_ThioEstase.
DR   InterPro; IPR043064; FcoT_ThioEstase_Rv0098-like_sf.
DR   Pfam; PF10862; FcoT; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Hydrolase; Lipid metabolism.
FT   CHAIN           1..183
FT                   /note="Long-chain fatty acyl-CoA thioesterase FcoT"
FT                   /id="PRO_0000103669"
SQ   SEQUENCE   183 AA;  20529 MW;  EC4FCF0B8032355F CRC64;
     MSHTDLTPCT RVLASSGTVP IAEELLARVL EPYSCKGCRY LIDAQYSATE DSVLAYGNFT
     IGESAYIRST GHFNAVELIL CFNQLAYSAF APAVLNEEIR VLRGWSIDDY CQHQLSSMLI
     RKASSRFRKP LNPQKFSARL LCRDLQVIER TWRYLKVPCV IEFWDENGGA ASGEIELAAL
     NIP