ID   FCOT_MYCTO              Reviewed;         183 AA.
AC   P9WM66; L0T4B3; P64685; Q10894;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Long-chain fatty acyl-CoA thioesterase FcoT {ECO:0000250|UniProtKB:P9WM67};
DE            EC=3.1.2.- {ECO:0000250|UniProtKB:P9WM67};
GN   Name=fcoT {ECO:0000250|UniProtKB:P9WM67}; OrderedLocusNames=MT0107;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Thiesterase that shows a preference for long chain fatty acyl
CC       groups. {ECO:0000250|UniProtKB:P9WM67}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+);
CC         Xref=Rhea:RHEA:16781, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:28868, ChEBI:CHEBI:57287, ChEBI:CHEBI:77636;
CC         Evidence={ECO:0000250|UniProtKB:P9WM67};
CC   -!- SIMILARITY: Belongs to the FcoT family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE000516; AAK44329.1; -; Genomic_DNA.
DR   PIR; B70751; B70751.
DR   RefSeq; WP_003899810.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WM66; -.
DR   SMR; P9WM66; -.
DR   EnsemblBacteria; AAK44329; AAK44329; MT0107.
DR   KEGG; mtc:MT0107; -.
DR   PATRIC; fig|83331.31.peg.112; -.
DR   HOGENOM; CLU_124481_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0047617; F:acyl-CoA hydrolase activity; IEA:RHEA.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.129.30; -; 1.
DR   InterPro; IPR022598; FcoT_ThioEstase.
DR   InterPro; IPR043064; FcoT_ThioEstase_Rv0098-like_sf.
DR   Pfam; PF10862; FcoT; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Hydrolase; Lipid metabolism.
FT   CHAIN           1..183
FT                   /note="Long-chain fatty acyl-CoA thioesterase FcoT"
FT                   /id="PRO_0000427357"
SQ   SEQUENCE   183 AA;  20529 MW;  EC4FCF0B8032355F CRC64;
     MSHTDLTPCT RVLASSGTVP IAEELLARVL EPYSCKGCRY LIDAQYSATE DSVLAYGNFT
     IGESAYIRST GHFNAVELIL CFNQLAYSAF APAVLNEEIR VLRGWSIDDY CQHQLSSMLI
     RKASSRFRKP LNPQKFSARL LCRDLQVIER TWRYLKVPCV IEFWDENGGA ASGEIELAAL
     NIP