FCP3C_DROME
ID FCP3C_DROME Reviewed; 282 AA.
AC P11450; O97173; Q32UU7; Q32UV1; Q32UV5; Q32UV9; Q32UW7; Q32UX5; Q32UX9;
AC Q32UY3; Q32UY7; Q32UZ9; Q32V15; Q32V31; Q32V35; Q32V47; Q32V51;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Follicle cell protein 3C-1;
GN Name=Fcp3C; ORFNames=CG4015;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND VARIANTS HIS-167
RP AND ALA-168.
RC TISSUE=Ovary;
RX PubMed=3119397; DOI=10.1016/0012-1606(87)90497-0;
RA Burke T., Waring G.L., Popodi E., Minoo P.;
RT "Characterization and sequence of follicle cell genes selectively expressed
RT during vitelline membrane formation in Drosophila.";
RL Dev. Biol. 124:441-450(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-71; ALA-74; ALA-75;
RP THR-77; THR-82; SER-108; VAL-109; THR-125; ILE-135; VAL-140; PRO-143;
RP GLY-152; LYS-163; THR-164; HIS-167 AND ALA-168.
RC STRAIN=Usa1, Usa11, Usa12, Usa13, Usa15, Usa16, Usa17, Usa18, Usa2, Usa3,
RC Usa4, Usa6, Usa7, Usa8, Usa9, Z36, Z50, Zim10, Zim13, Zim15, Zim16, Zim18,
RC Zim22, Zim39, Zim41, Zim42, and Zim7;
RX PubMed=16020794; DOI=10.1534/genetics.104.038851;
RA DuMont V.B., Aquadro C.F.;
RT "Multiple signatures of positive selection downstream of notch on the X
RT chromosome in Drosophila melanogaster.";
RL Genetics 171:639-653(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=P11450-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P11450-2; Sequence=VSP_037382;
CC -!- TISSUE SPECIFICITY: Expressed in follicle cells during vitelline
CC membrane formation. {ECO:0000269|PubMed:3119397}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M18281; AAA29016.1; -; Genomic_DNA.
DR EMBL; AY795911; AAY27431.1; -; Genomic_DNA.
DR EMBL; AY795912; AAY27436.1; -; Genomic_DNA.
DR EMBL; AY795914; AAY27444.1; -; Genomic_DNA.
DR EMBL; AY795913; AAY27440.1; -; Genomic_DNA.
DR EMBL; AY795915; AAY27448.1; -; Genomic_DNA.
DR EMBL; AY795916; AAY27452.1; -; Genomic_DNA.
DR EMBL; AY795917; AAY27456.1; -; Genomic_DNA.
DR EMBL; AY795918; AAY27460.1; -; Genomic_DNA.
DR EMBL; AY795919; AAY27464.1; -; Genomic_DNA.
DR EMBL; AY795920; AAY27468.1; -; Genomic_DNA.
DR EMBL; AY795921; AAY27472.1; -; Genomic_DNA.
DR EMBL; AY795922; AAY27476.1; -; Genomic_DNA.
DR EMBL; AY795923; AAY27480.1; -; Genomic_DNA.
DR EMBL; AY795924; AAY27484.1; -; Genomic_DNA.
DR EMBL; AY795925; AAY27488.1; -; Genomic_DNA.
DR EMBL; AY795926; AAY27492.1; -; Genomic_DNA.
DR EMBL; AY795927; AAY27496.1; -; Genomic_DNA.
DR EMBL; AY795928; AAY27500.1; -; Genomic_DNA.
DR EMBL; AY795929; AAY27504.1; -; Genomic_DNA.
DR EMBL; AY795930; AAY27508.1; -; Genomic_DNA.
DR EMBL; AY795931; AAY27512.1; -; Genomic_DNA.
DR EMBL; AY795932; AAY27516.1; -; Genomic_DNA.
DR EMBL; AY795933; AAY27520.1; -; Genomic_DNA.
DR EMBL; AY795934; AAY27524.1; -; Genomic_DNA.
DR EMBL; AY795935; AAY27528.1; -; Genomic_DNA.
DR EMBL; AY795936; AAY27532.1; -; Genomic_DNA.
DR EMBL; AY795937; AAY27536.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF45850.2; -; Genomic_DNA.
DR EMBL; AL035395; CAB37613.1; -; Genomic_DNA.
DR EMBL; BT025893; ABG02137.1; -; mRNA.
DR PIR; B27249; B27249.
DR RefSeq; NP_477482.2; NM_058134.5. [P11450-1]
DR AlphaFoldDB; P11450; -.
DR IntAct; P11450; 5.
DR STRING; 7227.FBpp0070517; -.
DR PaxDb; P11450; -.
DR DNASU; 31294; -.
DR EnsemblMetazoa; FBtr0070542; FBpp0070517; FBgn0000644. [P11450-1]
DR GeneID; 31294; -.
DR KEGG; dme:Dmel_CG4015; -.
DR CTD; 31294; -.
DR FlyBase; FBgn0000644; Fcp3C.
DR VEuPathDB; VectorBase:FBgn0000644; -.
DR eggNOG; ENOG502S2MI; Eukaryota.
DR HOGENOM; CLU_1016594_0_0_1; -.
DR InParanoid; P11450; -.
DR OMA; GREYCCR; -.
DR PhylomeDB; P11450; -.
DR BioGRID-ORCS; 31294; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31294; -.
DR PRO; PR:P11450; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0000644; Expressed in adult abdomen and 15 other tissues.
DR ExpressionAtlas; P11450; baseline and differential.
DR Genevisible; P11450; DM.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..282
FT /note="Follicle cell protein 3C-1"
FT /id="PRO_0000087209"
FT REGION 103..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|Ref.6"
FT /id="VSP_037382"
FT VARIANT 71
FT /note="S -> I (in strain: Usa13)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 74
FT /note="G -> A (in strain: Usa3, Usa16, Zim7, Zim10, Zim13,
FT Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 75
FT /note="V -> A (in strain: Usa3, Zim7, Zim10, Zim13, Zim16,
FT Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 77
FT /note="S -> T (in strain: Usa3, Usa16, Zim7, Zim10, Zim13,
FT Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 82
FT /note="A -> T (in strain: Zim39)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 108
FT /note="T -> S (in strain: Zim10, Zim13, Zim16, Zim18,
FT Zim39, Z36 and Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 109
FT /note="I -> V (in strain: Zim10, Zim13, Zim16, Zim18,
FT Zim39, Z36 and Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 125
FT /note="I -> T (in strain: Zim41)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 135
FT /note="M -> I (in strain: Zim15 and Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 140
FT /note="A -> V (in strain: Zim41)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 143
FT /note="L -> P (in strain: Usa1, Zim15, Zim18, Zim22, Zim39
FT and Zim42)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 152
FT /note="S -> G (in strain: Zim13)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 163
FT /note="T -> K (in strain: Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 164
FT /note="A -> T (in strain: Usa8, Usa12, Usa16, Zim7, Zim10,
FT Zim13, Zim15, Zim16, Zim18, Zim22, Zim39, Zim42, Z36 and
FT Z50)"
FT /evidence="ECO:0000269|PubMed:16020794"
FT VARIANT 167
FT /note="P -> H (in strain: Usa8 and Usa12)"
FT /evidence="ECO:0000269|PubMed:16020794,
FT ECO:0000269|PubMed:3119397"
FT VARIANT 168
FT /note="V -> A (in strain: Usa8, Usa12, Usa16, Zim18, Zim39
FT and Zim41)"
FT /evidence="ECO:0000269|PubMed:16020794,
FT ECO:0000269|PubMed:3119397"
FT CONFLICT 272..282
FT /note="SGVPYRCPLMG -> LGFPTVAH (in Ref. 1; AAA29016)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 282 AA; 30300 MW; 77BDD931187DC498 CRC64;
MDGAKAEVFS VSVDTKMGAF KNSLLLLTLL LAIHLEASKI VYKKPLYGNS NIIKDKRIKT
KPVKLETSTM SSTGVASSST TAEEDWPTAV EFVIMTTPAS ELEASTETIG NNGTTETTVG
EAPIIGSSEG STRSMEPTTA SPLMSTNPSS SSSLVSTIPL PPTAGLPVQD NQPVPCTCGV
FLSSQIPNGL PTKPLIHQEL DHMFPCNAIG RKQCQTKCLE TIVQHLPNSA NIVCSALGHD
CHKERAYLFI KNCHNQWVNT NLQAGREYCC RSGVPYRCPL MG
