FCRL1_HUMAN
ID FCRL1_HUMAN Reviewed; 429 AA.
AC Q96LA6; B2RE05; Q8N759; Q8NDI0; Q96PJ6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=Fc receptor-like protein 1;
DE Short=FcR-like protein 1;
DE Short=FcRL1;
DE AltName: Full=Fc receptor homolog 1;
DE Short=FcRH1;
DE AltName: Full=IFGP family protein 1;
DE Short=hIFGP1;
DE AltName: Full=Immune receptor translocation-associated protein 5;
DE AltName: CD_antigen=CD307a;
DE Flags: Precursor;
GN Name=FCRL1; Synonyms=FCRH1, IFGP1, IRTA5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Lymph node;
RX PubMed=11493702; DOI=10.1073/pnas.171308498;
RA Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.;
RT "Identification of a family of Fc receptor homologs with preferential B
RT cell expression.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Tonsil;
RX PubMed=12037601; DOI=10.1007/s00251-002-0436-x;
RA Guselnikov S.V., Ershova S.A., Mechetina L.V., Najakshin A.M.,
RA Volkova O.Y., Alabyev B.Y., Taranin A.V.;
RT "A family of highly diverse human and mouse genes structurally links
RT leukocyte FcR, gp42 and PECAM-1.";
RL Immunogenetics 54:87-95(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
RA Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
RA Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
RA Nickerson D.A.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Peripheral blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Blood;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP CHARACTERIZATION, AND TISSUE SPECIFICITY.
RX PubMed=11929751; DOI=10.1182/blood.v99.8.2662;
RA Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C.,
RA Dalla-Favera R.;
RT "IRTAs: a new family of immunoglobulin-like receptors differentially
RT expressed in B cells.";
RL Blood 99:2662-2669(2002).
RN [10]
RP FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INDUCTION, AND TISSUE
RP SPECIFICITY.
RX PubMed=15479727; DOI=10.1182/blood-2004-06-2344;
RA Leu C.-M., Davis R.S., Gartland L.A., Fine W.D., Cooper M.D.;
RT "FcRH1: an activation coreceptor on human B cells.";
RL Blood 105:1121-1126(2005).
RN [11]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16849395; DOI=10.1093/intimm/dxl069;
RA Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C.,
RA Hongo J.-A., Koeppen H., Ebens A.;
RT "Expression pattern of the human FcRH/IRTA receptors in normal tissue and
RT in B-chronic lymphocytic leukemia.";
RL Int. Immunol. 18:1363-1373(2006).
CC -!- FUNCTION: May function as an activating coreceptor in B-cells. May
CC function in B-cells activation and differentiation.
CC {ECO:0000269|PubMed:15479727}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15479727,
CC ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein
CC {ECO:0000269|PubMed:15479727, ECO:0000269|PubMed:16849395}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96LA6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96LA6-2; Sequence=VSP_033295;
CC Name=3;
CC IsoId=Q96LA6-3; Sequence=VSP_033293, VSP_033294;
CC Name=4;
CC IsoId=Q96LA6-4; Sequence=VSP_033290, VSP_033291, VSP_033292;
CC -!- TISSUE SPECIFICITY: Primarily expressed in secondary lymphoid tissues
CC by mature subsets of B-cells. Detected in spleen, lymph node, heart,
CC skeletal muscle, kidney, liver and placenta. Specifically expressed by
CC mature B lineage cells with higher expression in naive versus memory B-
CC cells (at protein level). {ECO:0000269|PubMed:11493702,
CC ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:15479727,
CC ECO:0000269|PubMed:16849395}.
CC -!- INDUCTION: Down-regulated in activated B-cells.
CC {ECO:0000269|PubMed:15479727}.
CC -!- PTM: Phosphorylated on tyrosines upon activation.
CC {ECO:0000269|PubMed:15479727}.
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DR EMBL; AY043464; AAK91777.1; -; mRNA.
DR EMBL; AF329488; AAL23898.1; -; mRNA.
DR EMBL; EF064734; ABK41917.1; -; Genomic_DNA.
DR EMBL; AK096690; BAC04842.1; -; mRNA.
DR EMBL; AK315748; BAG38102.1; -; mRNA.
DR EMBL; AL833970; CAD38815.1; -; mRNA.
DR EMBL; AL139409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW52861.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52862.1; -; Genomic_DNA.
DR EMBL; BC033690; AAH33690.1; -; mRNA.
DR CCDS; CCDS1170.1; -. [Q96LA6-1]
DR CCDS; CCDS53382.1; -. [Q96LA6-3]
DR CCDS; CCDS53383.1; -. [Q96LA6-2]
DR RefSeq; NP_001152869.1; NM_001159397.1. [Q96LA6-3]
DR RefSeq; NP_001152870.1; NM_001159398.1. [Q96LA6-2]
DR RefSeq; NP_443170.1; NM_052938.4. [Q96LA6-1]
DR AlphaFoldDB; Q96LA6; -.
DR SMR; Q96LA6; -.
DR BioGRID; 125427; 2.
DR IntAct; Q96LA6; 1.
DR STRING; 9606.ENSP00000357158; -.
DR GlyGen; Q96LA6; 1 site.
DR iPTMnet; Q96LA6; -.
DR PhosphoSitePlus; Q96LA6; -.
DR BioMuta; FCRL1; -.
DR DMDM; 74760931; -.
DR MassIVE; Q96LA6; -.
DR PaxDb; Q96LA6; -.
DR PeptideAtlas; Q96LA6; -.
DR PRIDE; Q96LA6; -.
DR ProteomicsDB; 77177; -. [Q96LA6-1]
DR ProteomicsDB; 77178; -. [Q96LA6-2]
DR ProteomicsDB; 77179; -. [Q96LA6-3]
DR ProteomicsDB; 77180; -. [Q96LA6-4]
DR Antibodypedia; 2561; 193 antibodies from 27 providers.
DR DNASU; 115350; -.
DR Ensembl; ENST00000358292.7; ENSP00000351039.3; ENSG00000163534.15. [Q96LA6-3]
DR Ensembl; ENST00000368176.8; ENSP00000357158.3; ENSG00000163534.15. [Q96LA6-1]
DR Ensembl; ENST00000491942.1; ENSP00000418130.1; ENSG00000163534.15. [Q96LA6-2]
DR GeneID; 115350; -.
DR KEGG; hsa:115350; -.
DR MANE-Select; ENST00000368176.8; ENSP00000357158.3; NM_052938.5; NP_443170.1.
DR UCSC; uc001frg.4; human. [Q96LA6-1]
DR CTD; 115350; -.
DR DisGeNET; 115350; -.
DR GeneCards; FCRL1; -.
DR HGNC; HGNC:18509; FCRL1.
DR HPA; ENSG00000163534; Group enriched (bone marrow, intestine, lymphoid tissue).
DR MIM; 606508; gene.
DR neXtProt; NX_Q96LA6; -.
DR OpenTargets; ENSG00000163534; -.
DR PharmGKB; PA142671766; -.
DR VEuPathDB; HostDB:ENSG00000163534; -.
DR eggNOG; ENOG502S65W; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR HOGENOM; CLU_023383_0_0_1; -.
DR InParanoid; Q96LA6; -.
DR OMA; GTHMEDQ; -.
DR OrthoDB; 53940at2759; -.
DR PhylomeDB; Q96LA6; -.
DR TreeFam; TF351107; -.
DR PathwayCommons; Q96LA6; -.
DR SignaLink; Q96LA6; -.
DR BioGRID-ORCS; 115350; 12 hits in 1059 CRISPR screens.
DR ChiTaRS; FCRL1; human.
DR GeneWiki; FCRL1; -.
DR GenomeRNAi; 115350; -.
DR Pharos; Q96LA6; Tbio.
DR PRO; PR:Q96LA6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96LA6; protein.
DR Bgee; ENSG00000163534; Expressed in vermiform appendix and 101 other tissues.
DR Genevisible; Q96LA6; HS.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015026; F:coreceptor activity; IDA:UniProtKB.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0042113; P:B cell activation; IDA:UniProtKB.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040878; Ig_C17orf99.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF17736; Ig_C17orf99; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..429
FT /note="Fc receptor-like protein 1"
FT /id="PRO_0000331638"
FT TOPO_DOM 17..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..429
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 17..104
FT /note="Ig-like C2-type 1"
FT DOMAIN 109..200
FT /note="Ig-like C2-type 2"
FT DOMAIN 208..291
FT /note="Ig-like C2-type 3"
FT MOTIF 354..359
FT /note="ITIM motif 1"
FT MOTIF 367..372
FT /note="ITIM motif 2"
FT MOTIF 379..384
FT /note="ITIM motif 3"
FT MOTIF 410..415
FT /note="ITIM motif 4"
FT MOTIF 423..428
FT /note="ITIM motif 5"
FT CARBOHYD 293
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 38..86
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 134..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 229..276
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..39
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033290"
FT VAR_SEQ 203..238
FT /note="IPVSRPILMLRAPRAQAAVEDVLELHCEALRGSPPI -> SKFHYPSFSQPV
FT TNWAPHFPGAHKVSLGHAEEVQWG (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033291"
FT VAR_SEQ 239..429
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_033292"
FT VAR_SEQ 296..334
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033293"
FT VAR_SEQ 372..429
FT /note="VNVVSGDEVYSLAYYNQPEQESVAAETLGTHMEDKVSLDIYSRLRKANITDV
FT DYEDAM -> EPREQSVAVHGRQQHSSEQKAQKPWGHIWRTRFP (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033294"
FT VAR_SEQ 395
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12037601"
FT /id="VSP_033295"
FT VARIANT 124
FT /note="V -> M (in dbSNP:rs12078586)"
FT /id="VAR_042923"
SQ SEQUENCE 429 AA; 46936 MW; F6BB19942C9C7C06 CRC64;
MLPRLLLLIC APLCEPAELF LIASPSHPTE GSPVTLTCKM PFLQSSDAQF QFCFFRDTRA
LGPGWSSSPK LQIAAMWKED TGSYWCEAQT MASKVLRSRR SQINVHRVPV ADVSLETQPP
GGQVMEGDRL VLICSVAMGT GDITFLWYKG AVGLNLQSKT QRSLTAEYEI PSVRESDAEQ
YYCVAENGYG PSPSGLVSIT VRIPVSRPIL MLRAPRAQAA VEDVLELHCE ALRGSPPILY
WFYHEDITLG SRSAPSGGGA SFNLSLTEEH SGNYSCEANN GLGAQRSEAV TLNFTVPTGA
RSNHLTSGVI EGLLSTLGPA TVALLFCYGL KRKIGRRSAR DPLRSLPSPL PQEFTYLNSP
TPGQLQPIYE NVNVVSGDEV YSLAYYNQPE QESVAAETLG THMEDKVSLD IYSRLRKANI
TDVDYEDAM
