FCRL5_HUMAN
ID FCRL5_HUMAN Reviewed; 977 AA.
AC Q96RD9; A0N0M2; B7WNT9; B7WP94; Q495Q2; Q495Q4; Q5VYK9; Q6UY46;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Fc receptor-like protein 5;
DE Short=FcR-like protein 5;
DE Short=FcRL5;
DE AltName: Full=BXMAS1;
DE AltName: Full=Fc receptor homolog 5;
DE Short=FcRH5;
DE AltName: Full=Immune receptor translocation-associated protein 2;
DE AltName: CD_antigen=CD307e;
DE Flags: Precursor;
GN Name=FCRL5; Synonyms=FCRH5, IRTA2; ORFNames=UNQ503/PRO820;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND VARIANTS HIS-267;
RP ASP-418 AND ILE-466.
RX PubMed=11453668; DOI=10.1006/bbrc.2001.5231;
RA Nakayama Y., Weissman S.M., Bothwell A.L.M.;
RT "BXMAS1 identifies a cluster of homologous genes differentially expressed
RT in B cells.";
RL Biochem. Biophys. Res. Commun. 285:830-837(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4 AND 5), TISSUE SPECIFICITY,
RP DISEASE, AND VARIANTS HIS-267; ASP-418 AND ILE-466.
RX PubMed=11290337; DOI=10.1016/s1074-7613(01)00109-1;
RA Hatzivassiliou G., Miller I., Takizawa J., Palanisamy N., Rao P.H.,
RA Iida S., Tagawa S., Taniwaki M., Russo J., Neri A., Cattoretti G.,
RA Clynes R., Mendelsohn C., Chaganti R.S.K., Dalla-Favera R.;
RT "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B
RT cells and involved in chromosome 1q21 abnormalities in B cell malignancy.";
RL Immunity 14:277-289(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS HIS-267; ILE-269;
RP ASP-418 AND ILE-466.
RX PubMed=11493702; DOI=10.1073/pnas.171308498;
RA Davis R.S., Wang Y.-H., Kubagawa H., Cooper M.D.;
RT "Identification of a family of Fc receptor homologs with preferential B
RT cell expression.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS HIS-267; ASP-418 AND
RP ILE-466.
RA Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
RA Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
RA Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
RA Nickerson D.A.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ILE-269;
RP ASP-418 AND ILE-466.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP TISSUE SPECIFICITY.
RX PubMed=11929751; DOI=10.1182/blood.v99.8.2662;
RA Miller I., Hatzivassiliou G., Cattoretti G., Mendelsohn C.,
RA Dalla-Favera R.;
RT "IRTAs: a new family of immunoglobulin-like receptors differentially
RT expressed in B cells.";
RL Blood 99:2662-2669(2002).
RN [10]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16849395; DOI=10.1093/intimm/dxl069;
RA Polson A.G., Zheng B., Elkins K., Chang W., Du C., Dowd P., Yen L., Tan C.,
RA Hongo J.-A., Koeppen H., Ebens A.;
RT "Expression pattern of the human FcRH/IRTA receptors in normal tissue and
RT in B-chronic lymphocytic leukemia.";
RL Int. Immunol. 18:1363-1373(2006).
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] CYS-687.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in B-cell development and differentiation in
CC peripheral lymphoid organs and may be useful markers of B-cell stages.
CC May have an immunoregulatory role in marginal zone B-cells.
CC {ECO:0000269|PubMed:11453668}.
CC -!- INTERACTION:
CC Q96RD9; Q9Y2J4: AMOTL2; NbExp=3; IntAct=EBI-12091825, EBI-746752;
CC Q96RD9; Q8TC20-4: CAGE1; NbExp=3; IntAct=EBI-12091825, EBI-11522698;
CC Q96RD9; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-12091825, EBI-739895;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1; Synonyms=IRTA2c;
CC IsoId=Q96RD9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96RD9-2; Sequence=VSP_017379, VSP_017380;
CC Name=3; Synonyms=IRTA2a;
CC IsoId=Q96RD9-3; Sequence=VSP_017385, VSP_017386;
CC Name=4; Synonyms=IRTA2b;
CC IsoId=Q96RD9-4; Sequence=VSP_017383, VSP_017384;
CC Name=5; Synonyms=IRTA2d;
CC IsoId=Q96RD9-5; Sequence=VSP_017381, VSP_017382;
CC -!- TISSUE SPECIFICITY: Expressed in marginal zone B-cells, immunoblasts,
CC tonsillar germinal center centrocytes and in the intraepithelial and
CC interfollicular regions of the tonsil. Expressed in many lymphoma cell
CC lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4
CC and isoform 5 are detected in lymph node, spleen, bone marrow, and
CC small intestine with preponderance of isoform 3. Expressed in mature
CC and memory B-cells and down-regulated in germinal center cells (at
CC protein level). {ECO:0000269|PubMed:11290337,
CC ECO:0000269|PubMed:11929751, ECO:0000269|PubMed:16849395}.
CC -!- DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as
CC the immunoreceptor tyrosine-based inhibitor motif (ITIM).
CC {ECO:0000250}.
CC -!- DISEASE: Note=A chromosomal aberration involving FCRL5 has been found
CC in cell lines with 1q21 abnormalities derived from Burkitt lymphoma.
CC Duplication dup(1)(q21q32). {ECO:0000269|PubMed:11290337}.
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DR EMBL; AF369794; AAK50059.2; -; mRNA.
DR EMBL; AF343662; AAK31325.1; -; mRNA.
DR EMBL; AF343663; AAK31326.1; -; mRNA.
DR EMBL; AF343664; AAK31327.1; -; mRNA.
DR EMBL; AF343665; AAK31328.1; -; mRNA.
DR EMBL; AF397453; AAK93971.1; -; mRNA.
DR EMBL; AY358085; AAQ88452.1; -; mRNA.
DR EMBL; AL834187; CAH56486.1; -; mRNA.
DR EMBL; EF064730; ABK41913.1; -; Genomic_DNA.
DR EMBL; AL135929; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101066; AAI01067.1; -; mRNA.
DR EMBL; BC101067; AAI01068.1; -; mRNA.
DR EMBL; BC101069; AAI01070.1; -; mRNA.
DR CCDS; CCDS1165.1; -. [Q96RD9-1]
DR RefSeq; NP_001182317.1; NM_001195388.1.
DR RefSeq; NP_112571.2; NM_031281.2. [Q96RD9-1]
DR AlphaFoldDB; Q96RD9; -.
DR BioGRID; 123640; 15.
DR IntAct; Q96RD9; 9.
DR STRING; 9606.ENSP00000354691; -.
DR GlyGen; Q96RD9; 4 sites.
DR iPTMnet; Q96RD9; -.
DR PhosphoSitePlus; Q96RD9; -.
DR BioMuta; FCRL5; -.
DR DMDM; 296439341; -.
DR jPOST; Q96RD9; -.
DR MassIVE; Q96RD9; -.
DR PaxDb; Q96RD9; -.
DR PeptideAtlas; Q96RD9; -.
DR PRIDE; Q96RD9; -.
DR ProteomicsDB; 77948; -. [Q96RD9-1]
DR ProteomicsDB; 77949; -. [Q96RD9-2]
DR ProteomicsDB; 77950; -. [Q96RD9-3]
DR ProteomicsDB; 77951; -. [Q96RD9-4]
DR ProteomicsDB; 77952; -. [Q96RD9-5]
DR ABCD; Q96RD9; 76 sequenced antibodies.
DR Antibodypedia; 47044; 223 antibodies from 30 providers.
DR DNASU; 83416; -.
DR Ensembl; ENST00000361835.8; ENSP00000354691.3; ENSG00000143297.19. [Q96RD9-1]
DR Ensembl; ENST00000368189.3; ENSP00000357172.3; ENSG00000143297.19. [Q96RD9-4]
DR Ensembl; ENST00000368190.7; ENSP00000357173.3; ENSG00000143297.19. [Q96RD9-3]
DR GeneID; 83416; -.
DR KEGG; hsa:83416; -.
DR MANE-Select; ENST00000361835.8; ENSP00000354691.3; NM_031281.3; NP_112571.2.
DR UCSC; uc001fqu.3; human. [Q96RD9-1]
DR CTD; 83416; -.
DR DisGeNET; 83416; -.
DR GeneCards; FCRL5; -.
DR HGNC; HGNC:18508; FCRL5.
DR HPA; ENSG00000143297; Tissue enriched (lymphoid).
DR MIM; 605877; gene.
DR neXtProt; NX_Q96RD9; -.
DR OpenTargets; ENSG00000143297; -.
DR PharmGKB; PA142671769; -.
DR VEuPathDB; HostDB:ENSG00000143297; -.
DR eggNOG; ENOG502S65W; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR HOGENOM; CLU_325948_0_0_1; -.
DR InParanoid; Q96RD9; -.
DR OMA; RFYHDDV; -.
DR OrthoDB; 53940at2759; -.
DR PhylomeDB; Q96RD9; -.
DR TreeFam; TF351107; -.
DR PathwayCommons; Q96RD9; -.
DR SignaLink; Q96RD9; -.
DR BioGRID-ORCS; 83416; 6 hits in 1061 CRISPR screens.
DR ChiTaRS; FCRL5; human.
DR GeneWiki; FCRL5; -.
DR GenomeRNAi; 83416; -.
DR Pharos; Q96RD9; Tbio.
DR PRO; PR:Q96RD9; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96RD9; protein.
DR Bgee; ENSG00000143297; Expressed in spleen and 107 other tissues.
DR Genevisible; Q96RD9; HS.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IDA:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 9.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF13895; Ig_2; 7.
DR SMART; SM00409; IG; 9.
DR SMART; SM00408; IGc2; 8.
DR SUPFAM; SSF48726; SSF48726; 9.
DR PROSITE; PS50835; IG_LIKE; 8.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..977
FT /note="Fc receptor-like protein 5"
FT /id="PRO_0000225622"
FT TOPO_DOM 16..851
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 852..872
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 873..977
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 23..101
FT /note="Ig-like C2-type 1"
FT DOMAIN 188..271
FT /note="Ig-like C2-type 2"
FT DOMAIN 287..374
FT /note="Ig-like C2-type 3"
FT DOMAIN 380..463
FT /note="Ig-like C2-type 4"
FT DOMAIN 473..556
FT /note="Ig-like C2-type 5"
FT DOMAIN 566..651
FT /note="Ig-like C2-type 6"
FT DOMAIN 659..744
FT /note="Ig-like C2-type 7"
FT DOMAIN 752..834
FT /note="Ig-like C2-type 8"
FT REGION 879..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 897..902
FT /note="ITIM motif 1"
FT MOTIF 910..915
FT /note="ITIM motif 2"
FT MOTIF 922..927
FT /note="ITIM motif 3"
FT MOTIF 952..957
FT /note="ITIM motif 4"
FT CARBOHYD 383
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 211..260
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 308..355
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 401..448
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 494..541
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 587..634
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 680..727
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 773..819
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 103..124
FT /note="ASLILQAPLSVFEGDSVVLRCR -> EMGFPHAAQANVELLGSSDLLT (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_017379"
FT VAR_SEQ 125..977
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_017380"
FT VAR_SEQ 152
FT /note="H -> Q (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:11290337"
FT /id="VSP_017381"
FT VAR_SEQ 153..977
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:11290337"
FT /id="VSP_017382"
FT VAR_SEQ 561..592
FT /note="VPVSRPILTLRVPRAQAVVGDLLELHCEAPRG -> GKCWVLASHPPLAEFS
FT LTHSFKNLFALSSFLP (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11290337"
FT /id="VSP_017383"
FT VAR_SEQ 593..977
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:11290337"
FT /id="VSP_017384"
FT VAR_SEQ 747..759
FT /note="VPVSRPVLTLRAP -> GEWALPTSSTSEN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11290337"
FT /id="VSP_017385"
FT VAR_SEQ 760..977
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11290337"
FT /id="VSP_017386"
FT VARIANT 267
FT /note="Y -> H (in dbSNP:rs6679793)"
FT /evidence="ECO:0000269|PubMed:11290337,
FT ECO:0000269|PubMed:11453668, ECO:0000269|PubMed:11493702,
FT ECO:0000269|Ref.6"
FT /id="VAR_025447"
FT VARIANT 269
FT /note="V -> I (in dbSNP:rs12036228)"
FT /evidence="ECO:0000269|PubMed:11493702,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_025448"
FT VARIANT 418
FT /note="G -> D (in dbSNP:rs2012199)"
FT /evidence="ECO:0000269|PubMed:11290337,
FT ECO:0000269|PubMed:11453668, ECO:0000269|PubMed:11493702,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.6"
FT /id="VAR_025449"
FT VARIANT 427
FT /note="N -> K (in dbSNP:rs16838748)"
FT /id="VAR_056044"
FT VARIANT 457
FT /note="Q -> R (in dbSNP:rs34868810)"
FT /id="VAR_056045"
FT VARIANT 466
FT /note="V -> I (in dbSNP:rs6427384)"
FT /evidence="ECO:0000269|PubMed:11290337,
FT ECO:0000269|PubMed:11453668, ECO:0000269|PubMed:11493702,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.6"
FT /id="VAR_025450"
FT VARIANT 687
FT /note="S -> C (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035514"
FT CONFLICT 733
FT /note="L -> P (in Ref. 1; AAK50059)"
FT /evidence="ECO:0000305"
FT CONFLICT 890
FT /note="S -> P (in Ref. 1; AAK50059)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 977 AA; 106437 MW; 9545DA1B6A164FDD CRC64;
MLLWVILLVL APVSGQFART PRPIIFLQPP WTTVFQGERV TLTCKGFRFY SPQKTKWYHR
YLGKEILRET PDNILEVQES GEYRCQAQGS PLSSPVHLDF SSASLILQAP LSVFEGDSVV
LRCRAKAEVT LNNTIYKNDN VLAFLNKRTD FHIPHACLKD NGAYRCTGYK ESCCPVSSNT
VKIQVQEPFT RPVLRASSFQ PISGNPVTLT CETQLSLERS DVPLRFRFFR DDQTLGLGWS
LSPNFQITAM WSKDSGFYWC KAATMPYSVI SDSPRSWIQV QIPASHPVLT LSPEKALNFE
GTKVTLHCET QEDSLRTLYR FYHEGVPLRH KSVRCERGAS ISFSLTTENS GNYYCTADNG
LGAKPSKAVS LSVTVPVSHP VLNLSSPEDL IFEGAKVTLH CEAQRGSLPI LYQFHHEGAA
LERRSANSAG GVAISFSLTA EHSGNYYCTA DNGFGPQRSK AVSLSVTVPV SHPVLTLSSA
EALTFEGATV TLHCEVQRGS PQILYQFYHE DMPLWSSSTP SVGRVSFSFS LTEGHSGNYY
CTADNGFGPQ RSEVVSLFVT VPVSRPILTL RVPRAQAVVG DLLELHCEAP RGSPPILYWF
YHEDVTLGSS SAPSGGEASF NLSLTAEHSG NYSCEANNGL VAQHSDTISL SVIVPVSRPI
LTFRAPRAQA VVGDLLELHC EALRGSSPIL YWFYHEDVTL GKISAPSGGG ASFNLSLTTE
HSGIYSCEAD NGLEAQRSEM VTLKVAVPVS RPVLTLRAPG THAAVGDLLE LHCEALRGSP
LILYRFFHED VTLGNRSSPS GGASLNLSLT AEHSGNYSCE ADNGLGAQRS ETVTLYITGL
TANRSGPFAT GVAGGLLSIA GLAAGALLLY CWLSRKAGRK PASDPARSPS DSDSQEPTYH
NVPAWEELQP VYTNANPRGE NVVYSEVRII QEKKKHAVAS DPRHLRNKGS PIIYSEVKVA
STPVSGSLFL ASSAPHR
