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FCRL5_MOUSE
ID   FCRL5_MOUSE             Reviewed;         596 AA.
AC   Q68SN8; E9QLI5; Q80WN2; Q8BJA5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Fc receptor-like protein 5;
DE            Short=FcR-like protein 5;
DE            Short=FcRL5;
DE   AltName: Full=BXMAS1-like protein 2;
DE            Short=mBXMH2;
DE   AltName: Full=Fc receptor homolog 3;
DE            Short=FcRH3;
DE            Short=moFcRH3;
DE   AltName: CD_antigen=CD307e;
DE   Flags: Precursor;
GN   Name=Fcrl5; Synonyms=Fcrh3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   STRAIN=BALB/cJ; TISSUE=Spleen;
RX   PubMed=15302849; DOI=10.1093/intimm/dxh137;
RA   Davis R.S., Stephan R.P., Chen C.-C., Dennis G. Jr., Cooper M.D.;
RT   "Differential B cell expression of mouse Fc receptor homologs.";
RL   Int. Immunol. 16:1343-1353(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J;
RA   Nakayama Y., Maher S.E., Weissman S.M., Bothwell A.L.M.;
RT   "Molecular cloning of mouse BXMAS1 homologs; homologous to IgFc receptor.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=NOD; TISSUE=Spleen;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBUNIT: Interacts with PTPN6, PTPN11, SYK and ZAP70. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q68SN8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q68SN8-2; Sequence=VSP_033309;
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in marginal zone B cells.
CC       {ECO:0000269|PubMed:15302849}.
CC   -!- PTM: Phosphorylated on cytoplasmic tyrosines; required for interaction
CC       with protein tyrosine phosphatases and protein tyrosine kinases.
CC       {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-14 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO20873.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY506558; AAS91578.1; -; mRNA.
DR   EMBL; AY158090; AAO20873.1; ALT_INIT; mRNA.
DR   EMBL; AK089756; BAC40954.1; -; mRNA.
DR   EMBL; AC163618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS50943.1; -. [Q68SN8-1]
DR   CCDS; CCDS50944.1; -. [Q68SN8-2]
DR   RefSeq; NP_001106709.1; NM_001113238.1. [Q68SN8-2]
DR   RefSeq; NP_899045.3; NM_183222.3. [Q68SN8-1]
DR   AlphaFoldDB; Q68SN8; -.
DR   SMR; Q68SN8; -.
DR   DIP; DIP-60955N; -.
DR   IntAct; Q68SN8; 1.
DR   STRING; 10090.ENSMUSP00000050151; -.
DR   GlyGen; Q68SN8; 2 sites.
DR   PhosphoSitePlus; Q68SN8; -.
DR   PaxDb; Q68SN8; -.
DR   PRIDE; Q68SN8; -.
DR   ProteomicsDB; 271685; -. [Q68SN8-1]
DR   ProteomicsDB; 271686; -. [Q68SN8-2]
DR   Antibodypedia; 47044; 223 antibodies from 30 providers.
DR   DNASU; 329693; -.
DR   Ensembl; ENSMUST00000049926; ENSMUSP00000050151; ENSMUSG00000048031. [Q68SN8-1]
DR   Ensembl; ENSMUST00000166297; ENSMUSP00000131176; ENSMUSG00000048031. [Q68SN8-2]
DR   Ensembl; ENSMUST00000193229; ENSMUSP00000141311; ENSMUSG00000048031. [Q68SN8-2]
DR   Ensembl; ENSMUST00000194102; ENSMUSP00000142210; ENSMUSG00000048031. [Q68SN8-1]
DR   GeneID; 329693; -.
DR   KEGG; mmu:329693; -.
DR   UCSC; uc008psf.1; mouse. [Q68SN8-2]
DR   UCSC; uc012crg.1; mouse. [Q68SN8-1]
DR   CTD; 83416; -.
DR   MGI; MGI:3053558; Fcrl5.
DR   VEuPathDB; HostDB:ENSMUSG00000048031; -.
DR   eggNOG; ENOG502S65W; Eukaryota.
DR   GeneTree; ENSGT01050000244808; -.
DR   HOGENOM; CLU_023383_6_1_1; -.
DR   InParanoid; Q68SN8; -.
DR   OMA; LPQKTKW; -.
DR   OrthoDB; 53940at2759; -.
DR   BioGRID-ORCS; 329693; 3 hits in 71 CRISPR screens.
DR   PRO; PR:Q68SN8; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q68SN8; protein.
DR   Bgee; ENSMUSG00000048031; Expressed in spleen and 5 other tissues.
DR   ExpressionAtlas; Q68SN8; baseline and differential.
DR   GO; GO:0009986; C:cell surface; ISO:MGI.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR   GO; GO:0043235; C:receptor complex; ISO:MGI.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IDA:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051649; P:establishment of localization in cell; IDA:MGI.
DR   GO; GO:0050859; P:negative regulation of B cell receptor signaling pathway; IDA:MGI.
DR   GO; GO:0051280; P:negative regulation of release of sequestered calcium ion into cytosol; IDA:MGI.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:MGI.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF13895; Ig_2; 3.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 4.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Phosphoprotein; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..596
FT                   /note="Fc receptor-like protein 5"
FT                   /id="PRO_0000331641"
FT   TOPO_DOM        27..496
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        497..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        518..596
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..115
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          106..199
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          207..294
FT                   /note="Ig-like C2-type 3"
FT   DOMAIN          296..384
FT                   /note="Ig-like C2-type 4"
FT   DOMAIN          398..483
FT                   /note="Ig-like C2-type 5"
FT   REGION          522..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        564..596
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        324
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        436
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        55..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        137..181
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        228..277
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        325..373
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        419..466
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VAR_SEQ         29..116
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_033309"
FT   CONFLICT        161..163
FT                   /note="PQS -> HQ (in Ref. 1; AAS91578 and 2; AAO20873)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        166
FT                   /note="F -> L (in Ref. 3; BAC40954)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="Y -> S (in Ref. 1; AAS91578 and 2; AAO20873)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        170
FT                   /note="R -> H (in Ref. 3; BAC40954)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        199
FT                   /note="V -> R (in Ref. 1; AAS91578 and 2; AAO20873)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        273
FT                   /note="K -> R (in Ref. 1; AAS91578 and 2; AAO20873)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        287
FT                   /note="S -> R (in Ref. 1; AAS91578, 2; AAO20873 and 3;
FT                   BAC40954)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        346
FT                   /note="K -> E (in Ref. 1; AAS91578 and 2; AAO20873)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        372
FT                   /note="Y -> H (in Ref. 1; AAS91578 and 2; AAO20873)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        373
FT                   /note="C -> R (in Ref. 3; BAC40954)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        376
FT                   /note="N -> T (in Ref. 1; AAS91578, 2; AAO20873 and 3;
FT                   BAC40954)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   596 AA;  66779 MW;  3EF9C7E4728461B4 CRC64;
     MSGSFSPCVV FTQMWLTLLV VTPVNGQHEA AQQSVVSLQP PWTTFFRGEV VTLTCYRFGF
     SVPQKTKWYQ KRKTVKQTPG ALVIKAHTLK VHESGEYWCQ ADSLLPSMHV NVEFSEDFLV
     LQAPPAVFEG DSVVLRCYAK KGIEAETLTF YKDGKALTLH PQSSEFYIHR ANLKDNGQYK
     CTSKKKWSFG SLYTSNTVVV QVQELFPRPV LRARPSHPID GSPVTLTCQT QLSAQKSDAR
     LQFCFFRNLQ LLGSGCSRSS EFHIPAIWTE ESKRYQCKAE TVNSQVSKQS TAFIIPVQRA
     SARFQTHIIP ASKLVFEGQL LLLNCSVKGV PGPLKFSWYK KDMLNKETKI LKSSNAEFKI
     SQVNISDAGE YYCEANNSRR SFVSRAFPIT IKVPVSQPVL TLSTGKTQAL EGDLMTLHCQ
     SQRGSPCILY EFFYENVSLG NSSILSGGGA YFNFSMSTER SGNYYCTADN GLGAQCSEAI
     RISIFDMTKN RSVPMAAGIT VGLLIMAVGV FLFYCWFSRK AGGKPTSDDS RNPSDSEPQE
     PTYYNVPACI ELQPVYSNEP EENVIYTEVR RTQPRQKHAD QESESPRSRC QMAEKK
 
 
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