FCRL6_MOUSE
ID FCRL6_MOUSE Reviewed; 268 AA.
AC A1YIY0; E9QM04;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Fc receptor-like protein 6;
DE Short=FcR-like protein 6;
DE Short=FcRL6;
DE Flags: Precursor;
GN Name=Fcrl6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J;
RX PubMed=17213291; DOI=10.1182/blood-2006-06-030023;
RA Wilson T.J., Presti R.M., Tassi I., Overton E.T., Cella M., Colonna M.;
RT "FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly
RT expressed by lymphocytes following HIV-1 infection.";
RL Blood 109:3786-3793(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Acts as a MHC class II receptor. When stimulated on its own,
CC does not play a role in cytokine production or the release of cytotoxic
CC granules by NK cells and cytotoxic CD8(+) T cells. Does not act as an
CC Fc receptor. {ECO:0000250|UniProtKB:Q6DN72}.
CC -!- SUBUNIT: Interacts with class II MHC. {ECO:0000250|UniProtKB:Q6DN72}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6DN72};
CC Single-pass type I membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A1YIY0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A1YIY0-2; Sequence=VSP_053295, VSP_053296;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF032497; ABL86186.1; -; mRNA.
DR EMBL; AC131177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS48448.1; -. [A1YIY0-1]
DR RefSeq; NP_001158197.1; NM_001164725.1. [A1YIY0-1]
DR AlphaFoldDB; A1YIY0; -.
DR STRING; 10090.ENSMUSP00000091861; -.
DR GlyGen; A1YIY0; 2 sites.
DR iPTMnet; A1YIY0; -.
DR PhosphoSitePlus; A1YIY0; -.
DR PaxDb; A1YIY0; -.
DR PRIDE; A1YIY0; -.
DR Antibodypedia; 47058; 92 antibodies from 15 providers.
DR Ensembl; ENSMUST00000094303; ENSMUSP00000091861; ENSMUSG00000070504. [A1YIY0-1]
DR GeneID; 677296; -.
DR KEGG; mmu:677296; -.
DR UCSC; uc011wwo.1; mouse. [A1YIY0-1]
DR CTD; 343413; -.
DR MGI; MGI:3618339; Fcrl6.
DR VEuPathDB; HostDB:ENSMUSG00000070504; -.
DR eggNOG; ENOG502RU0I; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR HOGENOM; CLU_023383_5_1_1; -.
DR InParanoid; A1YIY0; -.
DR OMA; YACEISA; -.
DR OrthoDB; 1363268at2759; -.
DR PhylomeDB; A1YIY0; -.
DR BioGRID-ORCS; 677296; 1 hit in 72 CRISPR screens.
DR PRO; PR:A1YIY0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; A1YIY0; protein.
DR Bgee; ENSMUSG00000070504; Expressed in placenta and 8 other tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042289; F:MHC class II protein binding; ISO:MGI.
DR GO; GO:0019902; F:phosphatase binding; ISO:MGI.
DR GO; GO:0019903; F:protein phosphatase binding; IPI:MGI.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0050776; P:regulation of immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040878; Ig_C17orf99.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF17736; Ig_C17orf99; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..268
FT /note="Fc receptor-like protein 6"
FT /id="PRO_0000280214"
FT TOPO_DOM 17..215
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 237..268
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 114..194
FT /note="Ig-like C2-type"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 135..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 244
FT /note="A -> G (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17213291"
FT /id="VSP_053295"
FT VAR_SEQ 245..268
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17213291"
FT /id="VSP_053296"
FT CONFLICT 19
FT /note="L -> Q (in Ref. 1; ABL86186)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 268 AA; 30237 MW; C75B513EA34DB0E7 CRC64;
MLLWMVLLLC ESMAEAQELF PNPELTEFTN SETMDVILKC TIKVDPKNPT LQLFYTFYKN
NHVIQDRSPH SVFSAEAKEE NSGLYQCMVD TEDGLIQKKS GYLDIQFWTP VSHPVLTLQH
EATNLAVGDK VEFLCEAHQG SLPIFYSFYI NGEILGKPLA PSGRAASLLA SVKAEWSTKN
YSCEAKNNIS REISELKKFP LVVSGTAWIK SNMLPIWLPA SLLGGMVIAA VVLMYFFKPC
KKHARPETPT LKEPDSFLYV SVDNQRYK
