FCRLA_HUMAN
ID FCRLA_HUMAN Reviewed; 359 AA.
AC Q7L513; A0N0M1; A6NC03; A6NL20; F5H720; F8W743; G3V1J2; Q5VXA1; Q5VXA2;
AC Q5VXA3; Q5VXA4; Q5VXB0; Q5VXB1; Q8NEW4; Q8WXH3; Q96PC6; Q96PJ0; Q96PJ1;
AC Q96PJ2; Q96PJ4; Q9BR57;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Fc receptor-like A;
DE AltName: Full=Fc receptor homolog expressed in B-cells;
DE AltName: Full=Fc receptor-like and mucin-like protein 1;
DE AltName: Full=Fc receptor-like protein;
DE AltName: Full=Fc receptor-related protein X;
DE Short=FcRX;
DE Flags: Precursor;
GN Name=FCRLA; Synonyms=FCRL, FCRL1, FCRLM1, FCRX, FREB;
GN ORFNames=UNQ291/PRO329;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 4; 5; 6 AND 7), FUNCTION,
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND VARIANT GLN-349.
RC TISSUE=Lymph, Melanocyte, and Tonsil;
RX PubMed=11754007;
RX DOI=10.1002/1521-4141(200201)32:1<87::aid-immu87>3.0.co;2-#;
RA Mechetina L.V., Najakshin A.M., Volkova O.Y., Guselnikov S.V.,
RA Faizulin R.Z., Alabyev B.Y., Chikaev N.A., Vinogradova M.S., Taranin A.V.;
RT "FCRL, a novel member of the leukocyte Fc receptor family possesses unique
RT structural features.";
RL Eur. J. Immunol. 32:87-96(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), FUNCTION, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND VARIANT GLN-349.
RX PubMed=11891275; DOI=10.1073/pnas.022042699;
RA Facchetti F., Cella M., Festa S., Fremont D.H., Colonna M.;
RT "An unusual Fc receptor-related protein expressed in human centroblasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:3776-3781(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 9), TISSUE SPECIFICITY, AND
RP VARIANT GLN-349.
RX PubMed=12202404; DOI=10.1093/intimm/dxf074;
RA Davis R.S., Li H., Chen C.-C., Wang Y.-H., Cooper M.D., Burrows P.D.;
RT "Definition of an Fc receptor-related gene (FcRX) expressed in human and
RT mouse B cells.";
RL Int. Immunol. 14:1075-1083(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 6; 7 AND 8), TISSUE
RP SPECIFICITY, AND SUBCELLULAR LOCATION.
RC TISSUE=Melanocyte;
RX PubMed=15551350; DOI=10.1002/ijc.20735;
RA Inozume T., Matsuzaki Y., Kurihara S., Fujita T., Yamamoto A.,
RA Aburatani H., Shimada S., Kawakami Y.;
RT "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison
RT using DNA chip are immunogenic in multiple melanoma patients.";
RL Int. J. Cancer 114:283-290(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT GLN-349.
RC TISSUE=Tonsil;
RA Guselnikov S., Najakshin A.M.;
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
RA Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
RA Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
RA Nickerson D.A.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 9), AND VARIANT
RP GLN-349.
RC TISSUE=Lymph, and Tonsil;
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [10]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-349.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [11]
RP PROTEIN SEQUENCE OF 28-42.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [12]
RP PROTEIN SEQUENCE OF 88-98; 252-259 AND 333-353, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=B-cell lymphoma;
RA Bienvenut W.V.;
RL Submitted (JUN-2005) to UniProtKB.
RN [13]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be implicated in B-cell differentiation and
CC lymphomagenesis. {ECO:0000269|PubMed:11754007,
CC ECO:0000269|PubMed:11891275}.
CC -!- SUBUNIT: Monomer or homodimer; disulfide-linked.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11754007,
CC ECO:0000269|PubMed:11891275, ECO:0000269|PubMed:15551350}. Note=Seems
CC not to be secreted. {ECO:0000269|PubMed:11891275}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=15;
CC Name=1; Synonyms=FCRLa;
CC IsoId=Q7L513-1; Sequence=Displayed;
CC Name=2; Synonyms=FCRLa1;
CC IsoId=Q7L513-2; Sequence=VSP_017605;
CC Name=3; Synonyms=FCRLb;
CC IsoId=Q7L513-3; Sequence=VSP_017608;
CC Name=4; Synonyms=FCRLc1;
CC IsoId=Q7L513-4; Sequence=VSP_017606;
CC Name=5; Synonyms=FCRLc2;
CC IsoId=Q7L513-5; Sequence=VSP_017604;
CC Name=6; Synonyms=FCRLd;
CC IsoId=Q7L513-6; Sequence=VSP_017607;
CC Name=7; Synonyms=FCRLe;
CC IsoId=Q7L513-7; Sequence=VSP_017603;
CC Name=8; Synonyms=FCRLf;
CC IsoId=Q7L513-8; Sequence=VSP_017609;
CC Name=9;
CC IsoId=Q7L513-9; Sequence=VSP_038297;
CC Name=10;
CC IsoId=Q7L513-10; Sequence=VSP_038297, VSP_017605;
CC Name=11;
CC IsoId=Q7L513-11; Sequence=VSP_038297, VSP_017606;
CC Name=12;
CC IsoId=Q7L513-12; Sequence=VSP_038297, VSP_017608;
CC Name=13;
CC IsoId=Q7L513-13; Sequence=VSP_038297, VSP_017607;
CC Name=14;
CC IsoId=Q7L513-14; Sequence=VSP_038297, VSP_017604;
CC Name=15;
CC IsoId=Q7L513-15; Sequence=VSP_038297, VSP_017603;
CC -!- TISSUE SPECIFICITY: Expressed specifically in primary and secondary
CC lymphoid tissues like lymph node, spleen and tonsil. Specifically
CC expressed in B-cells with a high level in normal germinal center B-
CC cells, centroblasts and in a subset of diffuse large B-cell lymphomas.
CC Highly expressed in bone marrow B-cells and weakly in earlier B lineage
CC cells. Expressed in pre-germinal and germinal center B-cells in
CC secondary lymphoid tissues. Also expressed in melanoma and melanocytes.
CC {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275,
CC ECO:0000269|PubMed:12202404, ECO:0000269|PubMed:15551350}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AF329489; AAL23899.1; -; mRNA.
DR EMBL; AF329491; AAL23901.1; -; mRNA.
DR EMBL; AF329493; AAL23903.1; -; mRNA.
DR EMBL; AF329494; AAL23904.1; -; mRNA.
DR EMBL; AF329495; AAL23905.1; -; mRNA.
DR EMBL; AF390036; AAL27307.1; -; mRNA.
DR EMBL; AF426461; AAL58111.1; -; mRNA.
DR EMBL; AF531423; AAM97591.1; -; mRNA.
DR EMBL; AY091642; AAM13980.2; -; mRNA.
DR EMBL; EF064729; ABK41912.1; -; Genomic_DNA.
DR EMBL; AY358348; AAQ88714.1; -; mRNA.
DR EMBL; AL359541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471067; EAW90683.1; -; Genomic_DNA.
DR EMBL; CH471067; EAW90684.1; -; Genomic_DNA.
DR EMBL; CH471067; EAW90685.1; -; Genomic_DNA.
DR EMBL; BC006521; AAH06521.2; -; mRNA.
DR CCDS; CCDS30926.1; -. [Q7L513-1]
DR CCDS; CCDS53415.1; -. [Q7L513-2]
DR CCDS; CCDS53416.1; -. [Q7L513-4]
DR CCDS; CCDS53417.1; -. [Q7L513-3]
DR CCDS; CCDS53418.1; -. [Q7L513-6]
DR CCDS; CCDS53419.1; -. [Q7L513-5]
DR CCDS; CCDS53420.1; -. [Q7L513-7]
DR RefSeq; NP_001171795.1; NM_001184866.1. [Q7L513-2]
DR RefSeq; NP_001171796.1; NM_001184867.1. [Q7L513-3]
DR RefSeq; NP_001171799.1; NM_001184870.1. [Q7L513-4]
DR RefSeq; NP_001171800.1; NM_001184871.1. [Q7L513-7]
DR RefSeq; NP_001171801.1; NM_001184872.1. [Q7L513-5]
DR RefSeq; NP_001171802.1; NM_001184873.1. [Q7L513-6]
DR RefSeq; NP_116127.3; NM_032738.3. [Q7L513-1]
DR PDB; 4HWN; X-ray; 2.01 A; A=169-264.
DR PDBsum; 4HWN; -.
DR AlphaFoldDB; Q7L513; -.
DR SMR; Q7L513; -.
DR BioGRID; 124282; 2.
DR IntAct; Q7L513; 4.
DR STRING; 9606.ENSP00000356936; -.
DR iPTMnet; Q7L513; -.
DR PhosphoSitePlus; Q7L513; -.
DR BioMuta; FCRLA; -.
DR DMDM; 90101291; -.
DR MassIVE; Q7L513; -.
DR MaxQB; Q7L513; -.
DR PaxDb; Q7L513; -.
DR PeptideAtlas; Q7L513; -.
DR PRIDE; Q7L513; -.
DR ProteomicsDB; 1444; -.
DR ProteomicsDB; 27358; -.
DR ProteomicsDB; 29885; -.
DR ProteomicsDB; 32350; -.
DR ProteomicsDB; 65585; -.
DR ProteomicsDB; 68782; -. [Q7L513-1]
DR ProteomicsDB; 68783; -. [Q7L513-2]
DR ProteomicsDB; 68784; -. [Q7L513-3]
DR ProteomicsDB; 68785; -. [Q7L513-4]
DR ProteomicsDB; 68786; -. [Q7L513-5]
DR ProteomicsDB; 68787; -. [Q7L513-6]
DR ProteomicsDB; 68788; -. [Q7L513-7]
DR ProteomicsDB; 68789; -. [Q7L513-8]
DR ProteomicsDB; 68790; -. [Q7L513-9]
DR ProteomicsDB; 793; -.
DR Antibodypedia; 34314; 111 antibodies from 22 providers.
DR DNASU; 84824; -.
DR Ensembl; ENST00000236938.12; ENSP00000236938.7; ENSG00000132185.18. [Q7L513-1]
DR Ensembl; ENST00000294796.8; ENSP00000294796.4; ENSG00000132185.18. [Q7L513-4]
DR Ensembl; ENST00000309691.10; ENSP00000309596.6; ENSG00000132185.18. [Q7L513-3]
DR Ensembl; ENST00000349527.8; ENSP00000294798.7; ENSG00000132185.18. [Q7L513-8]
DR Ensembl; ENST00000350710.3; ENSP00000344808.3; ENSG00000132185.18. [Q7L513-15]
DR Ensembl; ENST00000367949.6; ENSP00000356926.2; ENSG00000132185.18. [Q7L513-13]
DR Ensembl; ENST00000367953.7; ENSP00000356930.3; ENSG00000132185.18. [Q7L513-2]
DR Ensembl; ENST00000367957.7; ENSP00000356934.3; ENSG00000132185.18. [Q7L513-5]
DR Ensembl; ENST00000367959.6; ENSP00000356936.2; ENSG00000132185.18. [Q7L513-10]
DR Ensembl; ENST00000540521.5; ENSP00000442870.1; ENSG00000132185.18. [Q7L513-11]
DR Ensembl; ENST00000546024.5; ENSP00000439838.1; ENSG00000132185.18. [Q7L513-12]
DR Ensembl; ENST00000674251.1; ENSP00000501389.1; ENSG00000132185.18. [Q7L513-14]
DR Ensembl; ENST00000674323.1; ENSP00000501449.1; ENSG00000132185.18. [Q7L513-9]
DR GeneID; 84824; -.
DR KEGG; hsa:84824; -.
DR MANE-Select; ENST00000236938.12; ENSP00000236938.7; NM_032738.4; NP_116127.4.
DR UCSC; uc001gbd.4; human. [Q7L513-1]
DR CTD; 84824; -.
DR DisGeNET; 84824; -.
DR GeneCards; FCRLA; -.
DR HGNC; HGNC:18504; FCRLA.
DR HPA; ENSG00000132185; Tissue enriched (lymphoid).
DR MIM; 606891; gene.
DR neXtProt; NX_Q7L513; -.
DR OpenTargets; ENSG00000132185; -.
DR PharmGKB; PA162388180; -.
DR VEuPathDB; HostDB:ENSG00000132185; -.
DR eggNOG; ENOG502T149; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR HOGENOM; CLU_1824654_0_0_1; -.
DR InParanoid; Q7L513; -.
DR OMA; YHQMGIL; -.
DR PhylomeDB; Q7L513; -.
DR TreeFam; TF335097; -.
DR PathwayCommons; Q7L513; -.
DR SignaLink; Q7L513; -.
DR BioGRID-ORCS; 84824; 12 hits in 1059 CRISPR screens.
DR ChiTaRS; FCRLA; human.
DR GeneWiki; FCRLA; -.
DR GenomeRNAi; 84824; -.
DR Pharos; Q7L513; Tbio.
DR PRO; PR:Q7L513; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7L513; protein.
DR Bgee; ENSG00000132185; Expressed in ileal mucosa and 114 other tissues.
DR ExpressionAtlas; Q7L513; baseline and differential.
DR Genevisible; Q7L513; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Differentiation;
KW Direct protein sequencing; Disulfide bond; Immunoglobulin domain;
KW Reference proteome; Repeat; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 28..359
FT /note="Fc receptor-like A"
FT /id="PRO_0000227935"
FT DOMAIN 70..159
FT /note="Ig-like C2-type 1"
FT DOMAIN 170..257
FT /note="Ig-like C2-type 2"
FT REGION 259..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..303
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 99..143
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 192..240
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1
FT /note="M -> MLKKISVGVAGDLNTVTM (in isoform 9, isoform 10,
FT isoform 11, isoform 12, isoform 13, isoform 14 and isoform
FT 15)"
FT /evidence="ECO:0000303|PubMed:11891275,
FT ECO:0000303|PubMed:12202404, ECO:0000303|PubMed:12975309"
FT /id="VSP_038297"
FT VAR_SEQ 27..261
FT /note="Missing (in isoform 7 and isoform 15)"
FT /evidence="ECO:0000303|PubMed:11754007,
FT ECO:0000303|PubMed:15551350"
FT /id="VSP_017603"
FT VAR_SEQ 27..166
FT /note="Missing (in isoform 5 and isoform 14)"
FT /evidence="ECO:0000303|PubMed:11754007,
FT ECO:0000303|PubMed:15551350"
FT /id="VSP_017604"
FT VAR_SEQ 28
FT /note="A -> AGCHAAA (in isoform 2 and isoform 10)"
FT /evidence="ECO:0000303|Ref.5"
FT /id="VSP_017605"
FT VAR_SEQ 29..166
FT /note="SFETLQCEGPVCTEESSCHTEDDLTDAREAGFQVKAYTFSEPFHLIVSYDWL
FT ILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGSALGPPGPNREFSITVVQKADSG
FT HYHCSGIFQSPGPGIPETASVVAITVQ -> GCHA (in isoform 4 and
FT isoform 11)"
FT /evidence="ECO:0000303|PubMed:11754007"
FT /id="VSP_017606"
FT VAR_SEQ 78..261
FT /note="Missing (in isoform 6 and isoform 13)"
FT /evidence="ECO:0000303|PubMed:11754007,
FT ECO:0000303|PubMed:15551350"
FT /id="VSP_017607"
FT VAR_SEQ 78..166
FT /note="Missing (in isoform 3 and isoform 12)"
FT /evidence="ECO:0000303|PubMed:11754007,
FT ECO:0000303|PubMed:15551350"
FT /id="VSP_017608"
FT VAR_SEQ 167..261
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:15551350"
FT /id="VSP_017609"
FT VARIANT 349
FT /note="R -> Q (in dbSNP:rs11746)"
FT /evidence="ECO:0000269|PubMed:11754007,
FT ECO:0000269|PubMed:11891275, ECO:0000269|PubMed:12202404,
FT ECO:0000269|PubMed:12975309, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.5"
FT /id="VAR_025646"
FT CONFLICT 265
FT /note="S -> N (in Ref. 1; AAL23904)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="S -> P (in Ref. 1; AAL23903)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="L -> P (in Ref. 1; AAL27307)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="R -> G (in Ref. 1; AAL23905)"
FT /evidence="ECO:0000305"
FT STRAND 173..178
FT /evidence="ECO:0007829|PDB:4HWN"
FT STRAND 188..193
FT /evidence="ECO:0007829|PDB:4HWN"
FT STRAND 206..211
FT /evidence="ECO:0007829|PDB:4HWN"
FT STRAND 214..221
FT /evidence="ECO:0007829|PDB:4HWN"
FT STRAND 224..229
FT /evidence="ECO:0007829|PDB:4HWN"
FT HELIX 232..234
FT /evidence="ECO:0007829|PDB:4HWN"
FT STRAND 236..243
FT /evidence="ECO:0007829|PDB:4HWN"
FT STRAND 247..252
FT /evidence="ECO:0007829|PDB:4HWN"
FT STRAND 256..258
FT /evidence="ECO:0007829|PDB:4HWN"
SQ SEQUENCE 359 AA; 38927 MW; 76821DADB121499F CRC64;
MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED DLTDAREAGF
QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ AWQDWPLTQV TFYRDGSALG
PPGPNREFSI TVVQKADSGH YHCSGIFQSP GPGIPETASV VAITVQELFP APILRAVPSA
EPQAGSPMTL SCQTKLPLQR SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC
EAATEDNQVW KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS
SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK PGTTKATAE
