FCRLA_MOUSE
ID FCRLA_MOUSE Reviewed; 352 AA.
AC Q920A9; Q3T9Q2; Q8K3U9; Q8VHP5;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Fc receptor-like A;
DE AltName: Full=Fc receptor homolog expressed in B-cells;
DE AltName: Full=Fc receptor-like and mucin-like protein 1;
DE AltName: Full=Fc receptor-like protein;
DE AltName: Full=Fc receptor-related protein X;
DE Short=FcRX;
DE Flags: Precursor;
GN Name=Fcrla; Synonyms=Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=11754007;
RX DOI=10.1002/1521-4141(200201)32:1<87::aid-immu87>3.0.co;2-#;
RA Mechetina L.V., Najakshin A.M., Volkova O.Y., Guselnikov S.V.,
RA Faizulin R.Z., Alabyev B.Y., Chikaev N.A., Vinogradova M.S., Taranin A.V.;
RT "FCRL, a novel member of the leukocyte Fc receptor family possesses unique
RT structural features.";
RL Eur. J. Immunol. 32:87-96(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=11891275; DOI=10.1073/pnas.022042699;
RA Facchetti F., Cella M., Festa S., Fremont D.H., Colonna M.;
RT "An unusual Fc receptor-related protein expressed in human centroblasts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:3776-3781(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ;
RX PubMed=12202404; DOI=10.1093/intimm/dxf074;
RA Davis R.S., Li H., Chen C.-C., Wang Y.-H., Cooper M.D., Burrows P.D.;
RT "Definition of an Fc receptor-related gene (FcRX) expressed in human and
RT mouse B cells.";
RL Int. Immunol. 14:1075-1083(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be implicated in B-cell differentiation and
CC lymphomagenesis.
CC -!- SUBUNIT: Monomer or homodimer; disulfide-linked. {ECO:0000250}.
CC -!- INTERACTION:
CC Q920A9; P39429: Traf2; NbExp=5; IntAct=EBI-646587, EBI-520016;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7L513}.
CC Note=Seems not to be secreted. {ECO:0000250|UniProtKB:Q7L513}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q920A9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q920A9-2; Sequence=VSP_017610;
CC -!- TISSUE SPECIFICITY: Highly expressed in spleen. Expressed in immature
CC B-cell and B-cell lines. {ECO:0000269|PubMed:12202404}.
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DR EMBL; AF329487; AAL23897.1; -; mRNA.
DR EMBL; AF426462; AAL58112.1; -; mRNA.
DR EMBL; AF531424; AAM97592.1; -; mRNA.
DR EMBL; AK041572; BAC30990.1; -; mRNA.
DR EMBL; AK172370; BAE42968.1; -; mRNA.
DR EMBL; BC064708; AAH64708.1; -; mRNA.
DR CCDS; CCDS48439.1; -. [Q920A9-1]
DR CCDS; CCDS48440.1; -. [Q920A9-2]
DR RefSeq; NP_001153687.1; NM_001160215.1. [Q920A9-2]
DR RefSeq; NP_660123.1; NM_145141.2. [Q920A9-1]
DR AlphaFoldDB; Q920A9; -.
DR SMR; Q920A9; -.
DR BioGRID; 221124; 1.
DR IntAct; Q920A9; 1.
DR STRING; 10090.ENSMUSP00000036380; -.
DR iPTMnet; Q920A9; -.
DR PhosphoSitePlus; Q920A9; -.
DR EPD; Q920A9; -.
DR MaxQB; Q920A9; -.
DR PaxDb; Q920A9; -.
DR PRIDE; Q920A9; -.
DR ProteomicsDB; 271687; -. [Q920A9-1]
DR ProteomicsDB; 271688; -. [Q920A9-2]
DR Antibodypedia; 34314; 111 antibodies from 22 providers.
DR DNASU; 98752; -.
DR Ensembl; ENSMUST00000046322; ENSMUSP00000036380; ENSMUSG00000038421. [Q920A9-2]
DR Ensembl; ENSMUST00000159171; ENSMUSP00000124853; ENSMUSG00000038421. [Q920A9-1]
DR GeneID; 98752; -.
DR KEGG; mmu:98752; -.
DR UCSC; uc007dmq.2; mouse. [Q920A9-1]
DR UCSC; uc007dmr.2; mouse. [Q920A9-2]
DR CTD; 84824; -.
DR MGI; MGI:2138647; Fcrla.
DR VEuPathDB; HostDB:ENSMUSG00000038421; -.
DR eggNOG; ENOG502T149; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR HOGENOM; CLU_063170_0_0_1; -.
DR InParanoid; Q920A9; -.
DR OMA; YHQMGIL; -.
DR OrthoDB; 866496at2759; -.
DR PhylomeDB; Q920A9; -.
DR TreeFam; TF335097; -.
DR BioGRID-ORCS; 98752; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Fcrla; mouse.
DR PRO; PR:Q920A9; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q920A9; protein.
DR Bgee; ENSMUSG00000038421; Expressed in spleen and 62 other tissues.
DR ExpressionAtlas; Q920A9; baseline and differential.
DR Genevisible; Q920A9; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Differentiation; Disulfide bond;
KW Immunoglobulin domain; Reference proteome; Repeat; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000250"
FT CHAIN 31..352
FT /note="Fc receptor-like A"
FT /id="PRO_0000227936"
FT DOMAIN 80..169
FT /note="Ig-like C2-type 1"
FT DOMAIN 182..260
FT /note="Ig-like C2-type 2"
FT REGION 46..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 109..153
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 202..250
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 27
FT /note="A -> AA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11891275,
FT ECO:0000303|PubMed:12202404, ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_017610"
FT CONFLICT 19
FT /note="Missing (in Ref. 4; BAE42968)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="T -> I (in Ref. 4; BAE42968)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="S -> L (in Ref. 4; BAE42968)"
FT /evidence="ECO:0000305"
FT CONFLICT 69
FT /note="G -> D (in Ref. 4; BAE42968)"
FT /evidence="ECO:0000305"
FT CONFLICT 108
FT /note="H -> Y (in Ref. 4; BAE42968)"
FT /evidence="ECO:0000305"
FT CONFLICT 291..293
FT /note="PPP -> LPA (in Ref. 2; AAL58112)"
FT /evidence="ECO:0000305"
FT CONFLICT 321
FT /note="I -> M (in Ref. 4; BAE42968)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 352 AA; 38348 MW; 68836C3C2B6077B7 CRC64;
MKLSCTLTQW ALYVCPAVLL ATQMLLAASS ETLKCEGLVS TEQGSCQAAA EEDEGDEDDG
DMTQSSEAGF QFKGYTFSKP FHLSVSYDWL ILQGPATLIF EGDTLVLHCR AWQDWPLTQV
IFYREGSALG PPGPKSEFSI TMVQKSDGGH YHCSGIFRSP GPGSREAASP VAITVQELFA
APVLKALPSS EPQEGGSVTL SCQTKLALQR SASRLLFSFY KDGRSLSVRG VSSELKIPKA
SEEHSGSYWC EAVTEDRQIS KQSPQLEIWV QALQKPTASE TPPTEALGPL PPPPASSAEQ
PRFSSPDPHL HHQMQLLLKQ IQDVRALLGH LVMELRDLSV YLKPGTTKVA DK
