FCRLB_HUMAN
ID FCRLB_HUMAN Reviewed; 426 AA.
AC Q6BAA4; A2A3J5; A2A3J7; Q5VXA6; Q6BAA0; Q6BAA1; Q6BAA2; Q6BAA3; Q8IXZ7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Fc receptor-like B;
DE AltName: Full=Fc receptor homolog expressed in B-cells protein 2;
DE Short=FREB-2;
DE AltName: Full=Fc receptor-like and mucin-like protein 2;
DE AltName: Full=Fc receptor-like protein 2;
DE AltName: Full=Fc receptor-related protein Y;
DE Short=FcRY;
DE Flags: Precursor;
GN Name=FCRLB; Synonyms=FCRL2, FCRLM2, FCRY, FREB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=16263223; DOI=10.1016/j.gene.2005.08.016;
RA Masuda K., Davis R.S., Maruyama T., Zhang J., He T., Cooper M.D.,
RA O-Wang J., Burrows P.D.;
RT "FcRY, an Fc receptor related gene differentially expressed during B
RT lymphocyte development and activation.";
RL Gene 363:32-40(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Lymphoma;
RX PubMed=15815692; DOI=10.1038/sj.gene.6364185;
RA Wilson T.J., Colonna M.;
RT "A new Fc receptor homolog, FREB2, found in germinal center B cells.";
RL Genes Immun. 6:341-346(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=15676285; DOI=10.1016/j.ygeno.2004.10.017;
RA Chikaev N.A., Bykova E.A., Najakshin A.M., Mechetina L.V., Volkova O.Y.,
RA Peklo M.M., Shevelev A.Y., Vlasik T.N., Roesch A., Vogt T., Taranin A.V.;
RT "Cloning and characterization of the human FCRL2 gene.";
RL Genomics 85:264-272(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
RA Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B.,
RA Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O.,
RA Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I.,
RA Nickerson D.A.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Synovial cell;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 135-426 (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15551350; DOI=10.1002/ijc.20735;
RA Inozume T., Matsuzaki Y., Kurihara S., Fujita T., Yamamoto A.,
RA Aburatani H., Shimada S., Kawakami Y.;
RT "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison
RT using DNA chip are immunogenic in multiple melanoma patients.";
RL Int. J. Cancer 114:283-290(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15551350,
CC ECO:0000269|PubMed:15676285, ECO:0000269|PubMed:15815692}. Endoplasmic
CC reticulum {ECO:0000305|PubMed:15815692}. Note=Seems not to be secreted.
CC {ECO:0000269|PubMed:15676285}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Comment=Additional isoforms seem to exist.;
CC Name=1;
CC IsoId=Q6BAA4-1; Sequence=Displayed;
CC Name=2; Synonyms=FCRL2c1;
CC IsoId=Q6BAA4-2; Sequence=VSP_033421, VSP_033422;
CC Name=3; Synonyms=FCRL2c2;
CC IsoId=Q6BAA4-3; Sequence=VSP_033419, VSP_033421, VSP_033422;
CC Name=4; Synonyms=FCRL2b1;
CC IsoId=Q6BAA4-4; Sequence=VSP_033420, VSP_033423;
CC Name=5; Synonyms=FCRL2b2;
CC IsoId=Q6BAA4-5; Sequence=VSP_033419, VSP_033420, VSP_033423;
CC -!- TISSUE SPECIFICITY: Expressed at low levels. Expressed in B-
CC lymphocytes. Detected in tonsil, lung, kidney, spleen and placenta.
CC Expressed by a small subset of germinal center B-cells in tonsils and
CC by melanocytes (at protein level). {ECO:0000269|PubMed:15551350,
CC ECO:0000269|PubMed:15676285, ECO:0000269|PubMed:15815692,
CC ECO:0000269|PubMed:16263223}.
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DR EMBL; DQ021957; AAY42534.1; -; mRNA.
DR EMBL; AY786314; AAX11390.1; -; mRNA.
DR EMBL; AY670683; AAT77987.1; -; mRNA.
DR EMBL; AY670684; AAT77988.1; -; mRNA.
DR EMBL; AY670685; AAT77989.1; -; mRNA.
DR EMBL; AY670686; AAT77990.1; -; mRNA.
DR EMBL; AY670687; AAT77991.1; -; mRNA.
DR EMBL; EF064728; ABK41911.1; -; Genomic_DNA.
DR EMBL; AK290733; BAF83422.1; -; mRNA.
DR EMBL; AL359541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038564; AAH38564.2; -; mRNA.
DR CCDS; CCDS30927.1; -. [Q6BAA4-1]
DR CCDS; CCDS72962.1; -. [Q6BAA4-2]
DR CCDS; CCDS72963.1; -. [Q6BAA4-4]
DR CCDS; CCDS72964.1; -. [Q6BAA4-3]
DR CCDS; CCDS72965.1; -. [Q6BAA4-5]
DR RefSeq; NP_001002901.1; NM_001002901.3. [Q6BAA4-1]
DR RefSeq; NP_001275758.1; NM_001288829.1. [Q6BAA4-4]
DR RefSeq; NP_001275759.1; NM_001288830.1. [Q6BAA4-5]
DR RefSeq; NP_001275760.1; NM_001288831.1. [Q6BAA4-2]
DR RefSeq; NP_001275761.1; NM_001288832.1. [Q6BAA4-3]
DR RefSeq; NP_001307170.1; NM_001320241.1. [Q6BAA4-1]
DR AlphaFoldDB; Q6BAA4; -.
DR STRING; 9606.ENSP00000356925; -.
DR GlyGen; Q6BAA4; 1 site.
DR iPTMnet; Q6BAA4; -.
DR PhosphoSitePlus; Q6BAA4; -.
DR BioMuta; FCRLB; -.
DR DMDM; 74757430; -.
DR MassIVE; Q6BAA4; -.
DR PaxDb; Q6BAA4; -.
DR PeptideAtlas; Q6BAA4; -.
DR PRIDE; Q6BAA4; -.
DR ProteomicsDB; 66211; -. [Q6BAA4-1]
DR ProteomicsDB; 66212; -. [Q6BAA4-2]
DR ProteomicsDB; 66213; -. [Q6BAA4-3]
DR ProteomicsDB; 66214; -. [Q6BAA4-4]
DR ProteomicsDB; 66215; -. [Q6BAA4-5]
DR TopDownProteomics; Q6BAA4-5; -. [Q6BAA4-5]
DR Antibodypedia; 34315; 169 antibodies from 21 providers.
DR DNASU; 127943; -.
DR Ensembl; ENST00000336830.9; ENSP00000338598.5; ENSG00000162746.14. [Q6BAA4-2]
DR Ensembl; ENST00000367944.3; ENSP00000356921.3; ENSG00000162746.14. [Q6BAA4-3]
DR Ensembl; ENST00000367945.5; ENSP00000356922.1; ENSG00000162746.14. [Q6BAA4-5]
DR Ensembl; ENST00000367946.7; ENSP00000356923.3; ENSG00000162746.14. [Q6BAA4-4]
DR Ensembl; ENST00000367948.6; ENSP00000356925.2; ENSG00000162746.14. [Q6BAA4-1]
DR GeneID; 127943; -.
DR KEGG; hsa:127943; -.
DR MANE-Select; ENST00000367948.7; ENSP00000356925.2; NM_001002901.4; NP_001002901.1.
DR UCSC; uc001gbh.4; human. [Q6BAA4-1]
DR CTD; 127943; -.
DR DisGeNET; 127943; -.
DR GeneCards; FCRLB; -.
DR HGNC; HGNC:26431; FCRLB.
DR HPA; ENSG00000162746; Tissue enhanced (lymphoid).
DR MIM; 609251; gene.
DR neXtProt; NX_Q6BAA4; -.
DR OpenTargets; ENSG00000162746; -.
DR PharmGKB; PA162388195; -.
DR VEuPathDB; HostDB:ENSG00000162746; -.
DR eggNOG; ENOG502SH8W; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR HOGENOM; CLU_677141_0_0_1; -.
DR InParanoid; Q6BAA4; -.
DR OMA; PVRRFDW; -.
DR OrthoDB; 866496at2759; -.
DR PhylomeDB; Q6BAA4; -.
DR TreeFam; TF351107; -.
DR PathwayCommons; Q6BAA4; -.
DR BioGRID-ORCS; 127943; 9 hits in 1066 CRISPR screens.
DR GenomeRNAi; 127943; -.
DR Pharos; Q6BAA4; Tbio.
DR PRO; PR:Q6BAA4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6BAA4; protein.
DR Bgee; ENSG00000162746; Expressed in granulocyte and 117 other tissues.
DR Genevisible; Q6BAA4; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0050777; P:negative regulation of immune response; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Disulfide bond; Endoplasmic reticulum;
KW Glycoprotein; Immunoglobulin domain; Reference proteome; Repeat; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..426
FT /note="Fc receptor-like B"
FT /id="PRO_0000332992"
FT DOMAIN 23..101
FT /note="Ig-like C2-type 1"
FT DOMAIN 103..189
FT /note="Ig-like C2-type 2"
FT REGION 400..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 124..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 11..17
FT /note="Missing (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15676285"
FT /id="VSP_033419"
FT VAR_SEQ 192..318
FT /note="ELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAV
FT RRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDPASTTAPAP
FT WAAALAPGNRPLSFRK -> AARCAASTGAPSTQSRSPRSRSSNRTGARRLPPPAVSGN
FT AVRGCSSRGRVLPWTRPPPPPQLHGPQPWLLVIGRFPSESPRCPDRSRWSPPSGTPPPP
FT GCSSRRAAPRLRGHPPALRRRPWNNRLEP (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15676285"
FT /id="VSP_033420"
FT VAR_SEQ 193..275
FT /note="LFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQFAFYKYSRAVR
FT RFDWGAEYTVPEPEVEELESYWCEAATATRS -> ARHAAAVRVLQVQPRGAPLRLGRR
FT VHSPGARGRGARIVLVRGGYRHPQCPETQSVAAAPGAGFSPGPGLHHRPSSMGRSLGSW
FT (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15676285"
FT /id="VSP_033421"
FT VAR_SEQ 276..426
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15676285"
FT /id="VSP_033422"
FT VAR_SEQ 319..426
FT /note="Missing (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15676285"
FT /id="VSP_033423"
FT CONFLICT 18..19
FT /note="AT -> VP (in Ref. 3; AAT77989/AAT77990)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 46904 MW; D8AFD136B82D8962 CRC64;
MWPLTALLLL VPSSGQAATL EKPILSLHPP WTTIFKGERV TLKCDGYHPL LLELQPISTL
WYLGHLLLPS HKKSIEVQTP GVYRCQTRGA PVSDPIHLSV SNDWLILQVP YAPVFEGEPL
VLRCRGWYDK VVYKLHYYHD GQAVRYFHSS ANYTVLQARA SDSGRYQCSG TMRIPVESAP
MFSAKVAVTV QELFRAPVLR VMGPREARGA ALGGVVLRCD TRLHPQKRDT PLQFAFYKYS
RAVRRFDWGA EYTVPEPEVE ELESYWCEAA TATRSVRKRS PWLQLPGPGS PLDPASTTAP
APWAAALAPG NRPLSFRKPP VSRSVPLVTS VRNTTSTGLQ FPASGAPTAG PPACAPPTPL
EQSAGALKPD VDLLLREMQL LKGLLSRVVL ELKEPQALRE LRGTPETPTS HFAVSPGTPE
TTPVES
