FCRLB_MOUSE
ID FCRLB_MOUSE Reviewed; 427 AA.
AC Q5DRQ8; F8VQL1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Fc receptor-like B;
DE AltName: Full=Fc receptor homolog expressed in B-cells protein 2;
DE Short=FREB-2;
DE AltName: Full=Fc receptor-like and mucin-like protein 2;
DE AltName: Full=Fc receptor-like protein 2;
DE AltName: Full=Fc receptor-related protein Y;
DE Short=FcRY;
DE Flags: Precursor;
GN Name=Fcrlb; Synonyms=Fcrl2, Fcrlm2, Fcry, Freb2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=16263223; DOI=10.1016/j.gene.2005.08.016;
RA Masuda K., Davis R.S., Maruyama T., Zhang J., He T., Cooper M.D.,
RA O-Wang J., Burrows P.D.;
RT "FcRY, an Fc receptor related gene differentially expressed during B
RT lymphocyte development and activation.";
RL Gene 363:32-40(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129; TISSUE=Spleen;
RX PubMed=15815692; DOI=10.1038/sj.gene.6364185;
RA Wilson T.J., Colonna M.;
RT "A new Fc receptor homolog, FREB2, found in germinal center B cells.";
RL Genes Immun. 6:341-346(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6BAA4}.
CC Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6BAA4}. Note=Seems not to
CC be secreted. {ECO:0000250|UniProtKB:Q6BAA4}.
CC -!- TISSUE SPECIFICITY: Expressed at low levels. Expressed in B-
CC lymphocytes. Detected in spleen, lymph node, kidney, lung and brain.
CC {ECO:0000269|PubMed:15815692, ECO:0000269|PubMed:16263223}.
CC -!- INDUCTION: Up-regulated upon cell cycle arrest.
CC {ECO:0000269|PubMed:16263223}.
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DR EMBL; DQ119292; AAZ23789.1; -; mRNA.
DR EMBL; AY513660; AAS82875.1; -; mRNA.
DR EMBL; AC113490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS15475.1; -.
DR RefSeq; NP_001025155.2; NM_001029984.2.
DR AlphaFoldDB; Q5DRQ8; -.
DR STRING; 10090.ENSMUSP00000091895; -.
DR GlyGen; Q5DRQ8; 1 site.
DR iPTMnet; Q5DRQ8; -.
DR PhosphoSitePlus; Q5DRQ8; -.
DR PaxDb; Q5DRQ8; -.
DR PRIDE; Q5DRQ8; -.
DR Antibodypedia; 34315; 169 antibodies from 21 providers.
DR DNASU; 435653; -.
DR Ensembl; ENSMUST00000094337; ENSMUSP00000091895; ENSMUSG00000070524.
DR GeneID; 435653; -.
DR KEGG; mmu:435653; -.
DR UCSC; uc007dmp.1; mouse.
DR CTD; 127943; -.
DR MGI; MGI:3576487; Fcrlb.
DR VEuPathDB; HostDB:ENSMUSG00000070524; -.
DR eggNOG; ENOG502SH8W; Eukaryota.
DR GeneTree; ENSGT01050000244808; -.
DR HOGENOM; CLU_677141_0_0_1; -.
DR InParanoid; Q5DRQ8; -.
DR OMA; PVRRFDW; -.
DR OrthoDB; 866496at2759; -.
DR PhylomeDB; Q5DRQ8; -.
DR TreeFam; TF351107; -.
DR BioGRID-ORCS; 435653; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q5DRQ8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q5DRQ8; protein.
DR Bgee; ENSMUSG00000070524; Expressed in yolk sac and 11 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0050777; P:negative regulation of immune response; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 2.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Disulfide bond; Endoplasmic reticulum; Glycoprotein;
KW Immunoglobulin domain; Reference proteome; Repeat; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..427
FT /note="Fc receptor-like B"
FT /id="PRO_0000332993"
FT DOMAIN 23..101
FT /note="Ig-like C2-type 1"
FT DOMAIN 103..189
FT /note="Ig-like C2-type 2"
FT REGION 401..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 124..168
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 24
FT /note="V -> I (in Ref. 1; AAZ23789 and 2; AAS82875)"
FT /evidence="ECO:0000305"
FT CONFLICT 341
FT /note="H -> R (in Ref. 1; AAZ23789 and 2; AAS82875)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 427 AA; 47502 MW; 54D9F003FA9A7541 CRC64;
MWMLAALLLL VPRSGKAATL EKPVLTLHPP WTTIFKGERV TLRCDGYHPL LLELRPISTL
WYLGHVLLPS HKKSIEVQAP GVYRCQTRGA PVSDPIHLSV SNDWLILQVP YAAVFEGEPL
VMRCRGWYDK VVYKLHYYHD GQAVRYFHSS TNYTVLQARA SDSGHYQCSG TMRIPVESAP
MFSSKVAVTV QELFQTPVLR TLSPQEARGR VVLRCETRLH PQKRDTPLQF AFYKYSRPVR
RFDWGAEYTV PESEVEELES YWCEAATTSR SVRKRSPWLQ LPGRGPVLDL ASTTAPVAQA
AALGPGDKPL SFRKTPVSRS VQSVTSIPNS TFAGLQFPAG HVATAGPHAC APLPASAEQS
REALQPKVDL LLREMQLLKG LLSRVVLGLK DPQALHELTE TPETPNSHVT VNPATPETTV
MEGRVDS
