ID   FCS1_HAEIF              Reviewed;         364 AA.
AC   Q714U9;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Capsular polysaccharide phosphotransferase fcs1;
DE            EC=2.7.-.-;
DE   AltName: Full=Stealth protein fcs1;
GN   Name=fcs1;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=700222 / Serotype F;
RX   PubMed=14638817; DOI=10.1128/iai.71.12.7202-7207.2003;
RA   Satola S.W., Schirmer P.L., Farley M.M.;
RT   "Genetic analysis of the capsule locus of Haemophilus influenzae serotype
RT   f.";
RL   Infect. Immun. 71:7202-7207(2003).
RN   [2]
RP   IDENTIFICATION AS A STEALTH PROTEIN, AND PREDICTION OF FUNCTION.
RX   PubMed=16299590; DOI=10.1371/journal.pcbi.0010063;
RA   Sperisen P., Schmid C.D., Bucher P., Zilian O.;
RT   "Stealth proteins: in silico identification of a novel protein family
RT   rendering bacterial pathogens invisible to host immune defense.";
RL   PLoS Comput. Biol. 1:492-499(2005).
CC   -!- FUNCTION: Part of a group II capsule biosynthesis locus.
CC   -!- MISCELLANEOUS: Stealth proteins are part of a protein family that is
CC       conserved from bacteria to higher eukaryotes. Family members were first
CC       identified in microbes as proteins that help pathogens to elude the
CC       host innate immune system. Microbial stealth proteins are involved in
CC       the biosynthesis of exopolysaccharides. Stealth proteins are predicted
CC       to function as hexose-1-phosphoryltransferases.
CC   -!- SIMILARITY: Belongs to the stealth family. {ECO:0000305}.
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DR   EMBL; AF549211; AAQ12659.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q714U9; -.
DR   GO; GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR031358; Stealth_CR1.
DR   InterPro; IPR021520; Stealth_CR2.
DR   InterPro; IPR031357; Stealth_CR3.
DR   Pfam; PF17101; Stealth_CR1; 1.
DR   Pfam; PF11380; Stealth_CR2; 1.
DR   Pfam; PF17102; Stealth_CR3; 1.
PE   3: Inferred from homology;
KW   Exopolysaccharide synthesis; Transferase.
FT   CHAIN           1..364
FT                   /note="Capsular polysaccharide phosphotransferase fcs1"
FT                   /id="PRO_0000235945"
SQ   SEQUENCE   364 AA;  43203 MW;  FF5B947A5937C4FD CRC64;
     MKKLKKFVTK PHIFFRDALN NKYPIINNEQ GIKELDERAV LSHQENLEKL ESSLMNTPIP
     IDVVFTWVND KDEKWQEKKQ HYSKLANNYA FYAKDNVRFE EHNELFYSVK SVQKFLPWVR
     YIFIVTDNQI PHWLNNEDSQ IKIVDHREII DHDYLPTFNS HVIEANLHKI PNLSEHFIYF
     NDDVFVAKPL KKSHFFKPNG LASIFLSIKN LDKMYAKGTT TPTLLASMNS RRLLRKMYGQ
     ELNIQTPLIH SYIPLKKSVF EKIWSVFKEE IESFLSNRFR GKNDLNLATF FVPYAMYLEG
     KSVLTPEICY YFNIRSANAK AQYKKLLQKK ENGNRPHSFC INDTSSSNNH FYHKNFNTFI
     NLYF