FCTA_BRADU
ID FCTA_BRADU Reviewed; 425 AA.
AC Q89QH2;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Formyl-CoA:oxalate CoA-transferase;
DE Short=FCOCT;
DE EC=2.8.3.16 {ECO:0000255|HAMAP-Rule:MF_00742};
DE AltName: Full=Formyl-coenzyme A transferase {ECO:0000255|HAMAP-Rule:MF_00742};
DE Short=Formyl-CoA transferase {ECO:0000255|HAMAP-Rule:MF_00742};
GN Name=frc {ECO:0000255|HAMAP-Rule:MF_00742}; OrderedLocusNames=bll3156;
OS Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS NBRC 14792 / USDA 110).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Bradyrhizobiaceae; Bradyrhizobium.
OX NCBI_TaxID=224911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
CC -!- FUNCTION: Involved in the catabolism of oxalate and in the adapatation
CC to low pH via the induction of the oxalate-dependent acid tolerance
CC response (ATR). Catalyzes the transfer of the CoA moiety from formyl-
CC CoA to oxalate (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=formyl-CoA + oxalate = formate + oxalyl-CoA;
CC Xref=Rhea:RHEA:16545, ChEBI:CHEBI:15740, ChEBI:CHEBI:30623,
CC ChEBI:CHEBI:57376, ChEBI:CHEBI:57388; EC=2.8.3.16;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00742};
CC -!- PATHWAY: Metabolic intermediate degradation; oxalate degradation; CO(2)
CC and formate from oxalate: step 1/2. {ECO:0000255|HAMAP-Rule:MF_00742}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00742}.
CC -!- SIMILARITY: Belongs to the CoA-transferase III family. Frc subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_00742}.
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DR EMBL; BA000040; BAC48421.1; -; Genomic_DNA.
DR RefSeq; NP_769796.1; NC_004463.1.
DR RefSeq; WP_011085940.1; NZ_CP011360.1.
DR AlphaFoldDB; Q89QH2; -.
DR SMR; Q89QH2; -.
DR STRING; 224911.27351414; -.
DR EnsemblBacteria; BAC48421; BAC48421; BAC48421.
DR GeneID; 64022910; -.
DR KEGG; bja:bll3156; -.
DR PATRIC; fig|224911.44.peg.2796; -.
DR eggNOG; COG1804; Bacteria.
DR HOGENOM; CLU_033975_2_1_5; -.
DR InParanoid; Q89QH2; -.
DR OMA; FFWSPIN; -.
DR PhylomeDB; Q89QH2; -.
DR BRENDA; 2.8.3.16; 929.
DR UniPathway; UPA00540; UER00598.
DR Proteomes; UP000002526; Chromosome.
DR GO; GO:0033608; F:formyl-CoA transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0033611; P:oxalate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.1540.10; -; 1.
DR Gene3D; 3.40.50.10540; -; 1.
DR HAMAP; MF_00742; Formyl_CoA_transfer; 1.
DR InterPro; IPR003673; CoA-Trfase_fam_III.
DR InterPro; IPR044855; CoA-Trfase_III_dom3_sf.
DR InterPro; IPR023606; CoA-Trfase_III_dom_1_sf.
DR InterPro; IPR017659; Formyl_CoA_transfer.
DR Pfam; PF02515; CoA_transf_3; 1.
DR SUPFAM; SSF89796; SSF89796; 1.
DR TIGRFAMs; TIGR03253; oxalate_frc; 1.
PE 3: Inferred from homology;
KW Reference proteome; Transferase.
FT CHAIN 1..425
FT /note="Formyl-CoA:oxalate CoA-transferase"
FT /id="PRO_0000194721"
FT ACT_SITE 168
FT /note="Nucleophile"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00742"
FT BINDING 17..18
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000250"
FT BINDING 38
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00742"
FT BINDING 72..75
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000250"
FT BINDING 96..98
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000250"
FT BINDING 104
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00742"
FT BINDING 136..139
FT /ligand="CoA"
FT /ligand_id="ChEBI:CHEBI:57287"
FT /evidence="ECO:0000250"
FT BINDING 247..249
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 425 AA; 46424 MW; 306EC2A7FDF0048B CRC64;
MTKALTGVRI LDFTHVQSGP TCTQLLAWFG ADVIKVERPG VGDITRGQLQ DIPNVDSLYF
TMLNHNKRSI TLDTKNPKGK EVLTELIKKC DVLVENFGPG VLDRMGFPWE KIQQINPKMI
VASIKGFGPG PYEDCKVYEN VAQCTGGAAS TTGFRDGLPL VTGAQIGDSG TGLHLALGIV
TALYQRTHSG KGQRVTAAMQ DGVLNLARVK LRDQQRLAHG PLREYSQFGE GIPFGDAVPR
AGNDSGGGQP GRILKCKGWE TDPNAYIYFI TQAPVWEKIC DVIGEPTWKT DPNYAKPAAR
LPRLNEIFAR IEQWTMTKTK FEAMEILNKD DIPCGPILSM KEIAEDQSLR ATGTVVEVDH
PTRGKYISVG NPIKLSDSPS DVQRSPLLGE HTDEILRSVL GFSDHQVADI HKSGALAPPQ
KQAAE