ID   FCUA_YEREN              Reviewed;         758 AA.
AC   Q05202;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Ferrichrome receptor FcuA;
DE   Flags: Precursor;
GN   Name=fcuA;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-5 (PRECURSOR
RP   PROTEIN), AND PROTEIN SEQUENCE OF 37-46.
RC   STRAIN=Serotype O:8;
RX   PubMed=8384682; DOI=10.1111/j.1365-2958.1993.tb01130.x;
RA   Koebnik R., Hantke K., Braun V.;
RT   "The TonB-dependent ferrichrome receptor FcuA of Yersinia enterocolitica:
RT   evidence against a strict co-evolution of receptor structure and substrate
RT   specificity.";
RL   Mol. Microbiol. 7:383-393(1993).
CC   -!- FUNCTION: Receptor for the hydroxamate siderophore, ferrichrome. Binds
CC       also to most other ferrichrome derivatives except enantio ferrichrome
CC       and ferric rhodotorulate.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- INDUCTION: By iron starvation. Iron regulation mediated through the Fur
CC       protein.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; X67331; CAA47746.1; -; Genomic_DNA.
DR   PIR; S30948; S30948.
DR   RefSeq; WP_005170503.1; NZ_NWMR01000055.1.
DR   AlphaFoldDB; Q05202; -.
DR   SMR; Q05202; -.
DR   TCDB; 1.B.14.1.15; the outer membrane receptor (omr) family.
DR   OrthoDB; 196825at2; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR030149; FcuA/FatA.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR039423; TonB-dep_rcpt.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   InterPro; IPR010105; TonB_sidphr_rcpt.
DR   PANTHER; PTHR32552; PTHR32552; 1.
DR   PANTHER; PTHR32552:SF82; PTHR32552:SF82; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01783; TonB-siderophor; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Direct protein sequencing; Ion transport; Iron;
KW   Iron transport; Membrane; Receptor; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000269|PubMed:8384682"
FT   CHAIN           37..758
FT                   /note="Ferrichrome receptor FcuA"
FT                   /id="PRO_0000034753"
FT   MOTIF           66..73
FT                   /note="TonB box"
FT   MOTIF           741..758
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   758 AA;  81749 MW;  945675B0DEF49F7C CRC64;
     MNQTISSRAP QKRLAPRLLC VMIGAALGTL SASSWAAAAT DSTAENAKKT SATAATAKAE
     DSKTNDTITV VGAQETFRAG GNDLIPTYLD GQVANGGRIG FLGQQDARNV PFNVIGYTSK
     MIEDQQANSI ADVVKNDASV QNVRGYGNPS QNYRIRGYNL DGDDISFGGL FGVLPRQIVS
     TSMVERVEVF KGANAFINGI SPSGSGVGGM INLEPKRAGD TPLTRVTVDY GSASQVGGAL
     DVGRRYGDDD QFGVRVNVLH REGESAIHDQ KERTTAVSTG LDYRGDRART SLDVGYQKQT
     IHHMRTDVAI GGATVIPEPP SSTLNYGQSW VYTDMETTFG MLRSEYDVSQ NWTVYGSVGA
     SRNEETGQYG APMLTNNNGD ATISRLYVPY VADSVAGLGG IRGHFDTGPI THKVNLGYAA
     NYRTTKSAWN MSGQEDTNIY NPGVIGFPQT VMGSDSQDPQ LTSQVRASGL SLSDTLSMMD
     DKVSLMLGVR RQEVTIRNFD SGVPNSAGSL DAMKVTPIYG IMVKPWEKVS LYANHIEALG
     PGKSAPYQYN GKPVVNAGQI PGIIHSKQNE IGVKFDNQRY GGTLALFEIT RPTGMVDPAT
     NVYGFYGEQR NRGIELNVFG EPVFGTRLLA SATWLDPKLT KAADSANNGN DAVGVANYQL
     VFGGEYDIPV VEGLTATGTV VRSGSQYANE ANTLKLKPWT RLDLGVRYTM PMKDTSLTWR
     ANIENVTNER YWESVEDSGT YIYQGDPRAL KLSVSMDF