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FCY22_YEAST
ID   FCY22_YEAST             Reviewed;         530 AA.
AC   Q12119; D3DLW5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Purine-cytosine permease FCY22;
DE            Short=PCP FCY22;
DE   AltName: Full=Cytosine/purine transport protein FCY22;
DE   AltName: Full=Fluorocytosine resistance protein 22;
GN   Name=FCY22; Synonyms=FCYX; OrderedLocusNames=YER060W-A;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 28383 / FL100 / VTT C-80102;
RA   Straub M.-L., Souciet J.-L., Potier S., de Montigny J.;
RL   Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- FUNCTION: Probable purine-cytosine permease. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC       {ECO:0000305}.
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DR   EMBL; X97346; CAA66033.1; -; Genomic_DNA.
DR   EMBL; U18813; AAB64610.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07719.1; -; Genomic_DNA.
DR   RefSeq; NP_010982.1; NM_001180858.1.
DR   AlphaFoldDB; Q12119; -.
DR   BioGRID; 36802; 104.
DR   DIP; DIP-8900N; -.
DR   STRING; 4932.YER060W-A; -.
DR   PaxDb; Q12119; -.
DR   PRIDE; Q12119; -.
DR   EnsemblFungi; YER060W-A_mRNA; YER060W-A; YER060W-A.
DR   GeneID; 856789; -.
DR   KEGG; sce:YER060W-A; -.
DR   SGD; S000002958; FCY22.
DR   VEuPathDB; FungiDB:YER060W-A; -.
DR   eggNOG; ENOG502QQ8Y; Eukaryota.
DR   GeneTree; ENSGT00940000176331; -.
DR   HOGENOM; CLU_026016_2_2_1; -.
DR   InParanoid; Q12119; -.
DR   OMA; GRWANYE; -.
DR   BioCyc; YEAST:G3O-30354-MON; -.
DR   PRO; PR:Q12119; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; Q12119; protein.
DR   GO; GO:0071944; C:cell periphery; HDA:SGD.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISA:SGD.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IMP:SGD.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015856; P:cytosine transport; IMP:SGD.
DR   GO; GO:0072530; P:purine-containing compound transmembrane transport; ISA:SGD.
DR   InterPro; IPR012681; NCS1.
DR   InterPro; IPR001248; Pur-cyt_permease.
DR   InterPro; IPR026030; Pur-cyt_permease_Fcy2/21/22.
DR   PANTHER; PTHR31806; PTHR31806; 1.
DR   Pfam; PF02133; Transp_cyt_pur; 1.
DR   PIRSF; PIRSF002744; Pur-cyt_permease; 1.
DR   TIGRFAMs; TIGR00800; ncs1; 1.
PE   3: Inferred from homology;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..530
FT                   /note="Purine-cytosine permease FCY22"
FT                   /id="PRO_0000197922"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        298..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        345..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        463..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         46
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P40039"
SQ   SEQUENCE   530 AA;  57327 MW;  620FF2F2F3A2702D CRC64;
     MPEKLAMSMV DIKDAGSELR DLESGALDTK SSAADVYYEG VELHRTNEFI DNKPSFFNRI
     AAALNAETKG IEPVTEDEKN DDSILNAATI WFSANMVIVA YSVGALGPLV FGLNFGQSVL
     VIIFFNILGL IPVALFSLFG VELGLRQMIL SRYLAGNITA RFFSLVNVIA CVGWCVLNIS
     VSAQLLNMVN EGSGHNCPIW AGCLIIAGGT VLVTFFGYSV VHAYEKWSWV PNFAAFLVII
     AQLSRSGKFK GGEWVGGATT AGGVLSFGSS VFGSAAGWAT YAADYTVYMP KTTSKYKIFF
     SVVAGLAFPL FFTMILGAAC GMAALNDPTW KSYYDKNAMG GVIYAILVPN SLNGFGQFCC
     VLLALSTVAN NVPGMYTVAL SAQALWAPLA KIPRVVWTMA GNAATLGISI PATYYFDGFM
     ENFMDSIGYY LAIYIAIACS EHFIYRRSFS AYNIDDWDNW EHLPIGIAGT AALIAGAFGV
     ALGMCQTYWV GEISRLIGEY GGDIGFELGG SWAFIIYNIV RPLELKYFGR
 
 
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