FD2_DROME
ID FD2_DROME Reviewed; 365 AA.
AC Q02360; Q9VZK0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 184.
DE RecName: Full=Fork head domain-containing protein FD2;
GN Name=fd64A; Synonyms=FD2; ORFNames=CG1132;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-209, FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=1356269; DOI=10.1073/pnas.89.18.8754;
RA Haecker U., Grossniklaus U., Gehring W.J., Jaeckle H.;
RT "Developmentally regulated Drosophila gene family encoding the fork head
RT domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8754-8758(1992).
CC -!- FUNCTION: Involved in development during embryogenesis.
CC {ECO:0000269|PubMed:1356269}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic posterior mesoderm.
CC {ECO:0000269|PubMed:1356269}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos, maximal level between 5-12
CC hours. {ECO:0000269|PubMed:1356269}.
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DR EMBL; AE014296; AAF47821.1; -; Genomic_DNA.
DR EMBL; M96441; AAA28533.1; -; Genomic_DNA.
DR PIR; B46178; B46178.
DR RefSeq; NP_001246609.1; NM_001259680.2.
DR RefSeq; NP_523912.1; NM_079188.3.
DR AlphaFoldDB; Q02360; -.
DR SMR; Q02360; -.
DR BioGRID; 63957; 16.
DR DIP; DIP-19169N; -.
DR IntAct; Q02360; 6.
DR STRING; 7227.FBpp0301542; -.
DR PaxDb; Q02360; -.
DR PRIDE; Q02360; -.
DR DNASU; 38471; -.
DR EnsemblMetazoa; FBtr0073192; FBpp0073048; FBgn0004895.
DR EnsemblMetazoa; FBtr0309789; FBpp0301542; FBgn0004895.
DR GeneID; 38471; -.
DR KEGG; dme:Dmel_CG1132; -.
DR CTD; 2300; -.
DR FlyBase; FBgn0004895; fd64A.
DR VEuPathDB; VectorBase:FBgn0004895; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000162251; -.
DR HOGENOM; CLU_797590_0_0_1; -.
DR InParanoid; Q02360; -.
DR OMA; NNHRPEK; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q02360; -.
DR BioGRID-ORCS; 38471; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 38471; -.
DR PRO; PR:Q02360; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0004895; Expressed in trunk mesoderm and 11 other tissues.
DR ExpressionAtlas; Q02360; baseline and differential.
DR Genevisible; Q02360; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..365
FT /note="Fork head domain-containing protein FD2"
FT /id="PRO_0000091910"
FT DNA_BIND 90..181
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 183..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 40635 MW; 4FCEF59A285FCA0F CRC64;
MLPSCYANGS MLPDNEELVN SMLANPDYLR TQVSPNPLAP SAVGGAGMEG LMCGSFSPAF
YYQGIDSFLA LHNNIWGLPI SFLHNSHRPE KPPFSYIALI AMAISSAPNQ RLTLSGIYKF
IMDKFPYYRE NKQGWQNSIR HNLSLNDCFV KIPRDKNTIE DNDSAGKGSY WMLDSSASDM
FEQGNYRRRR TRRQRHCGHP NRYERESGKD SNDGNSSAAE IRSPSEPLSD FDIFCNERPN
YSDRITDLHR QYLSVSLGFN SLFNNEARGL RPLPEIRECP DDVDASSSSS KAMQSSMELH
EELHSPSAFT PPLNRRETSS SGAPVLAEAF NGIKDVVDAP GSSPVASSNR SKTTLFTIDN
IIGKP
