FD3_DROME
ID FD3_DROME Reviewed; 456 AA.
AC Q02361; Q1LZ28; Q8T4G1; Q9W1Y5;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 181.
DE RecName: Full=Fork head domain-containing protein FD3;
GN Name=fd59A; Synonyms=FD3; ORFNames=CG3668;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-197, FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=1356269; DOI=10.1073/pnas.89.18.8754;
RA Haecker U., Grossniklaus U., Gehring W.J., Jaeckle H.;
RT "Developmentally regulated Drosophila gene family encoding the fork head
RT domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8754-8758(1992).
CC -!- FUNCTION: Involved in development during embryogenesis.
CC {ECO:0000269|PubMed:1356269}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: During embryogenesis, expressed in neuroblasts
CC derived from procephalic region, ventral nervous system, thoracic
CC sensory neurons and brain cells. {ECO:0000269|PubMed:1356269}.
CC -!- DEVELOPMENTAL STAGE: Expressed at very low levels during embryogenesis.
CC {ECO:0000269|PubMed:1356269}.
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DR EMBL; AE013599; AAF46917.1; -; Genomic_DNA.
DR EMBL; AY084204; AAL89942.1; -; mRNA.
DR EMBL; BT025198; ABF17889.1; -; mRNA.
DR EMBL; M96442; AAA28534.1; -; Genomic_DNA.
DR PIR; C46178; C46178.
DR RefSeq; NP_523814.1; NM_079090.3.
DR AlphaFoldDB; Q02361; -.
DR SMR; Q02361; -.
DR BioGRID; 63243; 44.
DR DIP; DIP-19745N; -.
DR IntAct; Q02361; 4.
DR STRING; 7227.FBpp0071809; -.
DR PaxDb; Q02361; -.
DR DNASU; 37631; -.
DR EnsemblMetazoa; FBtr0071898; FBpp0071809; FBgn0004896.
DR GeneID; 37631; -.
DR KEGG; dme:Dmel_CG3668; -.
DR CTD; 37631; -.
DR FlyBase; FBgn0004896; fd59A.
DR VEuPathDB; VectorBase:FBgn0004896; -.
DR eggNOG; KOG2294; Eukaryota.
DR GeneTree; ENSGT00940000157140; -.
DR HOGENOM; CLU_044772_1_0_1; -.
DR InParanoid; Q02361; -.
DR OMA; FNFFANA; -.
DR OrthoDB; 1270467at2759; -.
DR PhylomeDB; Q02361; -.
DR SignaLink; Q02361; -.
DR BioGRID-ORCS; 37631; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 37631; -.
DR PRO; PR:Q02361; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0004896; Expressed in central brain primordium (Drosophila) and 11 other tissues.
DR ExpressionAtlas; Q02361; baseline and differential.
DR Genevisible; Q02361; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..456
FT /note="Fork head domain-containing protein FD3"
FT /id="PRO_0000091911"
FT DNA_BIND 84..175
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..368
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 225
FT /note="E -> D (in Ref. 3; AAL89942)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 456 AA; 49054 MW; 208FEAF27C953F4B CRC64;
MHTSTDPMHT LHDSVSLSPP LIKSSRGGSS IGNGIGCSAS SRTAAADAMS MGCDDSDIEP
SSMGGSGAAG GNGDGSGSSG GPLVKPPYSY IALITMAILQ SPHKKLTLSG ICDFIMSRFP
YYKDKFPAWQ NSIRHNLSLN DCFIKVPREP GNPGKGNFWT LDPLAEDMFD NGSFLRRRKR
YKRAPTMQRF SFPAVFGTLS PFWIRKPVPL VPVHFNVPNF NGSREFDVVH NPADVFDSAL
RADKKFNFFA NAEASFYQGS QSGDKFDRLP FMNRGRGADV LDALPHSSGS GGGVGGGSES
SRGSKYKSPY AFDVATVASA AGIPGHRDYA ERLSAGGGYM DLNVYNDDAD TEADAEAEGD
DDSCEDKIDV ESGNEQEDSH ISDSVDSACT NRLDAPPEAL IFEASAEASD SSPRRRFDSE
PLVLRTSKQS SAKDFRIETL IGHHLHRGGS QEETSD
