FD4L1_ARATH
ID FD4L1_ARATH Reviewed; 295 AA.
AC O04584;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Fatty acid desaturase 4-like 1, chloroplastic;
DE Short=FAD4-L1;
DE EC=1.14.19.-;
DE Flags: Precursor;
GN Name=FAD4L1; OrderedLocusNames=At1g62190; ORFNames=F19K23.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19682287; DOI=10.1111/j.1365-313x.2009.04001.x;
RA Gao J., Ajjawi I., Manoli A., Sawin A., Xu C., Froehlich J.E., Last R.L.,
RA Benning C.;
RT "FATTY ACID DESATURASE4 of Arabidopsis encodes a protein distinct from
RT characterized fatty acid desaturases.";
RL Plant J. 60:832-839(2009).
CC -!- FUNCTION: Fatty acid desaturase involved in the production of
CC chloroplast-specific phosphatidylglycerol molecular species. Catalyzes
CC the formation of a trans double bond introduced close to the carboxyl
CC group of palmitic acid, which is specifically esterified to the sn-2
CC glyceryl carbon of phosphatidylglycerol (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Lipid metabolism; fatty acid metabolism.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase CarF family.
CC {ECO:0000305}.
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DR EMBL; AC000375; AAB60765.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33934.1; -; Genomic_DNA.
DR PIR; D96648; D96648.
DR RefSeq; NP_176410.1; NM_104900.3.
DR AlphaFoldDB; O04584; -.
DR STRING; 3702.AT1G62190.1; -.
DR PaxDb; O04584; -.
DR PRIDE; O04584; -.
DR ProteomicsDB; 230408; -.
DR EnsemblPlants; AT1G62190.1; AT1G62190.1; AT1G62190.
DR GeneID; 842515; -.
DR Gramene; AT1G62190.1; AT1G62190.1; AT1G62190.
DR KEGG; ath:AT1G62190; -.
DR Araport; AT1G62190; -.
DR TAIR; locus:2018022; AT1G62190.
DR eggNOG; KOG3011; Eukaryota.
DR HOGENOM; CLU_065233_0_0_1; -.
DR InParanoid; O04584; -.
DR OMA; RQFANNS; -.
DR PhylomeDB; O04584; -.
DR UniPathway; UPA00199; -.
DR PRO; PR:O04584; -.
DR Proteomes; UP000006548; Chromosome 1.
DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR019547; Lipid_desat.
DR Pfam; PF10520; Lipid_desat; 1.
PE 3: Inferred from homology;
KW Chloroplast; Fatty acid metabolism; Lipid metabolism; Membrane;
KW Oxidoreductase; Plastid; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..29
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 30..295
FT /note="Fatty acid desaturase 4-like 1, chloroplastic"
FT /id="PRO_0000429928"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 295 AA; 32954 MW; 489D390FA7EDA680 CRC64;
MAVSFQTKNP LRPITNIPRS YGPTRVRVTC SVTTTNPQLN HENLVVEKRL VNPPLSKNND
PTLQSTWTHR LWVAAGSTTI FASFAKSIIG GFGSHLWLQP ALACYAGYVF ADLGSGVYHW
AIDNYGGAST PIVGAQLEAS QGHHKYPWTI TKRQFANNSY TIARAITFIV LPLNLAINNP
LFHSFVSTFA FCILLSQQFH AWAHGTKSKL PPLVMALQDM GLLVSRKDHP GHHQAPYNSN
YCVVSGAWNK VLDESNLFKA LEMALFFQFG VRPNSWNEPN SDWTEETETN FFTKI