FD4_DROME
ID FD4_DROME Reviewed; 372 AA.
AC P32028; Q058R6; Q9VBY1;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Fork head domain-containing protein FD4;
GN Name=fd96Ca; Synonyms=FD4; ORFNames=CG11921;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125, FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=1356269; DOI=10.1073/pnas.89.18.8754;
RA Haecker U., Grossniklaus U., Gehring W.J., Jaeckle H.;
RT "Developmentally regulated Drosophila gene family encoding the fork head
RT domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8754-8758(1992).
CC -!- FUNCTION: Involved in development during embryogenesis.
CC {ECO:0000269|PubMed:1356269}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in early embryogenesis in 14 symmetrical
CC pairs of segmentally arranged neuroblasts. Also, later in
CC embryogenesis, in a cluster of cells in head region.
CC {ECO:0000269|PubMed:1356269}.
CC -!- DEVELOPMENTAL STAGE: Expressed in 5-12 hours embryos.
CC {ECO:0000269|PubMed:1356269}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF02179.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014297; AAF56396.1; -; Genomic_DNA.
DR EMBL; BT029152; ABJ17087.1; -; mRNA.
DR EMBL; M96443; AAF02179.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_001287516.1; NM_001300587.1.
DR RefSeq; NP_524495.1; NM_079771.2.
DR AlphaFoldDB; P32028; -.
DR SMR; P32028; -.
DR BioGRID; 67931; 5.
DR IntAct; P32028; 5.
DR STRING; 7227.FBpp0084145; -.
DR PaxDb; P32028; -.
DR DNASU; 43010; -.
DR EnsemblMetazoa; FBtr0084770; FBpp0084145; FBgn0004897.
DR EnsemblMetazoa; FBtr0339246; FBpp0308353; FBgn0004897.
DR GeneID; 43010; -.
DR KEGG; dme:Dmel_CG11921; -.
DR CTD; 43010; -.
DR FlyBase; FBgn0004897; fd96Ca.
DR VEuPathDB; VectorBase:FBgn0004897; -.
DR eggNOG; KOG3562; Eukaryota.
DR GeneTree; ENSGT00940000161970; -.
DR HOGENOM; CLU_040357_6_1_1; -.
DR InParanoid; P32028; -.
DR OMA; DKPEHHS; -.
DR OrthoDB; 1236900at2759; -.
DR PhylomeDB; P32028; -.
DR BioGRID-ORCS; 43010; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 43010; -.
DR PRO; PR:P32028; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004897; Expressed in maxillary sensory complex primordium (Drosophila) and 12 other tissues.
DR ExpressionAtlas; P32028; baseline and differential.
DR Genevisible; P32028; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..372
FT /note="Fork head domain-containing protein FD4"
FT /id="PRO_0000091912"
FT DNA_BIND 12..103
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT REGION 225..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 41723 MW; C3BEBEDC0EDAC1E3 CRC64;
MPRPSRESYG EQKPPYSYIS LTAMAIWSSP EKMLPLSDIY KFITDRFPYY RKNTQRWQNS
LRHNLSFNDC FIKVPRRPDR PGKGAYWALH PQAFDMFENG SLLRRRKRFK LHKNDKDLLN
EELTALANLN RFFFTTRNGG SAAHMSPLDM NNAAAMRLDP LPRSTAHMPN SLGPGVPLPH
VMPASMSGAD HTNLADMGLT NLPALTSSEI EGPLSLRPKR SFTIESLITP DKPEHPSEDE
DDEDDRVDID VVECSGISRY PTTPAASEEY MSASRSSRTE DPLPPMHTIN AGAHVPFLHY
ATGANVAGLP ASGIPNSPTT YELAISHPLF MMAAPIANMH NIYYNNVTLV APAQQYRSPE
VQNRIDNDMR TI
