FD5_DROME
ID FD5_DROME Reviewed; 271 AA.
AC P32029; Q0IGQ4; Q9VBY0;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Fork head domain-containing protein FD5;
GN Name=fd96Cb; Synonyms=FD5; ORFNames=CG11922;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-125, FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=1356269; DOI=10.1073/pnas.89.18.8754;
RA Haecker U., Grossniklaus U., Gehring W.J., Jaeckle H.;
RT "Developmentally regulated Drosophila gene family encoding the fork head
RT domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8754-8758(1992).
CC -!- FUNCTION: Involved in development during embryogenesis.
CC {ECO:0000269|PubMed:1356269}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in early embryogenesis in 14 symmetrical
CC pairs of segmentally arranged neuroblasts and in developing peripheral
CC nervous system. Also, later in embryogenesis, in a cluster of cells in
CC head region. {ECO:0000269|PubMed:1356269}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos (maximal level between 5-12
CC hours) and at a low level in larvae. {ECO:0000269|PubMed:1356269}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF02178.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014297; AAF56397.1; -; Genomic_DNA.
DR EMBL; BT028866; ABI34247.2; -; mRNA.
DR EMBL; M96444; AAF02178.1; ALT_INIT; Genomic_DNA.
DR PIR; E46178; E46178.
DR RefSeq; NP_524496.1; NM_079772.2.
DR AlphaFoldDB; P32029; -.
DR SMR; P32029; -.
DR BioGRID; 67932; 7.
DR IntAct; P32029; 6.
DR STRING; 7227.FBpp0084146; -.
DR PaxDb; P32029; -.
DR DNASU; 43011; -.
DR EnsemblMetazoa; FBtr0084771; FBpp0084146; FBgn0004898.
DR GeneID; 43011; -.
DR KEGG; dme:Dmel_CG11922; -.
DR CTD; 43011; -.
DR FlyBase; FBgn0004898; fd96Cb.
DR VEuPathDB; VectorBase:FBgn0004898; -.
DR eggNOG; KOG3562; Eukaryota.
DR GeneTree; ENSGT00940000160522; -.
DR HOGENOM; CLU_084871_0_0_1; -.
DR InParanoid; P32029; -.
DR OMA; PCYQKTP; -.
DR OrthoDB; 1236900at2759; -.
DR PhylomeDB; P32029; -.
DR BioGRID-ORCS; 43011; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 43011; -.
DR PRO; PR:P32029; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004898; Expressed in embryonic ventral epidermis (Drosophila) and 16 other tissues.
DR ExpressionAtlas; P32029; baseline and differential.
DR Genevisible; P32029; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00059; FH; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..271
FT /note="Fork head domain-containing protein FD5"
FT /id="PRO_0000091913"
FT DNA_BIND 12..103
FT /note="Fork-head"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00089"
FT CONFLICT 33..34
FT /note="LL -> FV (in Ref. 4; AAF02178)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 31013 MW; AE7C06114CEDDCC2 CRC64;
MPRPLKMSYG DQKPPYSYIS LTAMAIIHSP QRLLPLSEIY RFIMDQFPFY RKNTQKWQNS
LRHNLSFNDC FIKVPRNVTK AGKGSYWTLH PMAFDMFENG SLLRRRKRFR VKQLEKDISN
WKLAAAANTE MVTHYLDDQL TQMAFADPAR HGHVLANASA AQMSPYKATP PILPTTVTQL
PARPKRAFTI ESLMAPDPAS TPNEGLVPME YGSPDAVALE KPPFNLPFNF NELAAQYQLY
FPSFFYNGQY GNIPCYQKTP PLFHNGPLPV F
