ID   FDB19_FUSPC             Reviewed;         296 AA.
AC   K3VFR5;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2012, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Solute carrier protein FPSE_08119 {ECO:0000305|PubMed:25727347};
DE   AltName: Full=Fusarium detoxification of benzoxazolinone cluster protein FPSE_08119 {ECO:0000303|PubMed:25727347};
DE            Short=FDB cluster protein FPSE_08119 {ECO:0000303|PubMed:25727347};
GN   ORFNames=FPSE_08119;
OS   Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=1028729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CS3096;
RX   PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA   Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA   Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT   "Comparative pathogenomics reveals horizontally acquired novel virulence
RT   genes in fungi infecting cereal hosts.";
RL   PLoS Pathog. 8:E1002952-E1002952(2012).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=25727347; DOI=10.1111/mpp.12250;
RA   Kettle A.J., Batley J., Benfield A.H., Manners J.M., Kazan K.,
RA   Gardiner D.M.;
RT   "Degradation of the benzoxazolinone class of phytoalexins is important for
RT   virulence of Fusarium pseudograminearum towards wheat.";
RL   Mol. Plant Pathol. 16:946-962(2015).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=26828593; DOI=10.1016/j.fgb.2016.01.015;
RA   Kettle A.J., Carere J., Batley J., Manners J.M., Kazan K., Gardiner D.M.;
RT   "The Fdb3 transcription factor of the Fusarium Detoxification of
RT   Benzoxazolinone gene cluster is required for MBOA but not BOA degradation
RT   in Fusarium pseudograminearum.";
RL   Fungal Genet. Biol. 88:44-53(2016).
CC   -!- FUNCTION: Solute carrier protein; part of the Fusarium detoxification
CC       of benzoxazolinone cluster involved in the degradation of
CC       benzoxazolinones produced by the host plant (PubMed:25727347,
CC       PubMed:26828593). Maize, wheat, and rye produce the 2 benzoxazinone
CC       phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA)
CC       and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their
CC       inherent instability once released, spontaneously degrade to the more
CC       stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone
CC       (MBOA) and 2-benzoxazolinone (BOA), respectively (By similarity).
CC       {ECO:0000250|UniProtKB:W7MLD5, ECO:0000269|PubMed:25727347,
CC       ECO:0000269|PubMed:26828593}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is induced in response to 2-benzoxasolinone (BOA)
CC       exposure (PubMed:25727347). Expression is also induced in response to
CC       6-methoxy-2-benzoxazolinone (MBOA) and 2-aminophenol (2-AP) treatment
CC       (PubMed:26828593). {ECO:0000269|PubMed:25727347,
CC       ECO:0000269|PubMed:26828593}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AFNW01000283; EKJ71673.1; -; Genomic_DNA.
DR   RefSeq; XP_009259512.1; XM_009261237.1.
DR   STRING; 101028.EKJ71673; -.
DR   EnsemblFungi; EKJ71673; EKJ71673; FPSE_08119.
DR   GeneID; 20366737; -.
DR   KEGG; fpu:FPSE_08119; -.
DR   eggNOG; KOG0759; Eukaryota.
DR   HOGENOM; CLU_015166_14_1_1; -.
DR   InParanoid; K3VFR5; -.
DR   Proteomes; UP000007978; Chromosome 2.
DR   Proteomes; UP000007978; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Repeat;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..296
FT                   /note="Solute carrier protein FPSE_08119"
FT                   /id="PRO_0000454606"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          16..102
FT                   /note="Solcar 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT   REPEAT          114..205
FT                   /note="Solcar 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
FT   REPEAT          213..296
FT                   /note="Solcar 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00282"
SQ   SEQUENCE   296 AA;  31915 MW;  FA9B0FC343C79BD1 CRC64;
     MTDAEVIPLT KGLAALQTAL PFIVGCGSGM VATTCVQPID TIKVRLQLAD RSVLRVTTWS
     IARDLMVEGG ILNMYQGLSA AIMRSLVYGT MRLGLFSTFE KELARRARER GTTLSFGERS
     LAGVGAGALA AVVGNPTEVI LIRMQTDGLK PLSQQARYSS AVDALRRIAS HEGVLALWKG
     AGPTLIRAMS INFGQLTSFS EAKNQLQEHT SLSPPVRTAV AAGIAGCLGA LISQPFDFVK
     TRLQNQVKTS PTVGLGSGEL LYKGTFDCLF KVIHKEGLFR LYRDILPYFM RIGPHS