FDB27_FUSPC
ID FDB27_FUSPC Reviewed; 476 AA.
AC K3UII4;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2012, sequence version 1.
DT 23-FEB-2022, entry version 26.
DE RecName: Full=Transmembrane transporter FPSE_08127 {ECO:0000303|PubMed:25727347};
DE AltName: Full=Fusarium detoxification of benzoxazolinone cluster protein FPSE_08127 {ECO:0000303|PubMed:25727347};
DE Short=FDB cluster protein FPSE_08127 {ECO:0000303|PubMed:25727347};
GN ORFNames=FPSE_08127;
OS Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=1028729;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CS3096;
RX PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT "Comparative pathogenomics reveals horizontally acquired novel virulence
RT genes in fungi infecting cereal hosts.";
RL PLoS Pathog. 8:E1002952-E1002952(2012).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=25727347; DOI=10.1111/mpp.12250;
RA Kettle A.J., Batley J., Benfield A.H., Manners J.M., Kazan K.,
RA Gardiner D.M.;
RT "Degradation of the benzoxazolinone class of phytoalexins is important for
RT virulence of Fusarium pseudograminearum towards wheat.";
RL Mol. Plant Pathol. 16:946-962(2015).
RN [3]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=26828593; DOI=10.1016/j.fgb.2016.01.015;
RA Kettle A.J., Carere J., Batley J., Manners J.M., Kazan K., Gardiner D.M.;
RT "The Fdb3 transcription factor of the Fusarium Detoxification of
RT Benzoxazolinone gene cluster is required for MBOA but not BOA degradation
RT in Fusarium pseudograminearum.";
RL Fungal Genet. Biol. 88:44-53(2016).
CC -!- FUNCTION: Transmembrane transporter; part of the Fusarium
CC detoxification of benzoxazolinone cluster involved in the degradation
CC of benzoxazolinones produced by the host plant (PubMed:25727347,
CC PubMed:26828593). Maize, wheat, and rye produce the 2 benzoxazinone
CC phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA)
CC and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their
CC inherent instability once released, spontaneously degrade to the more
CC stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone
CC (MBOA) and 2-benzoxazolinone (BOA), respectively (By similarity).
CC FPSE_08127 is proposed to shuttle metabolites of benzoxazolinone
CC degradation (Probable). {ECO:0000250|UniProtKB:W7MLD5,
CC ECO:0000269|PubMed:25727347, ECO:0000269|PubMed:26828593,
CC ECO:0000305|PubMed:26828593}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Expression is induced in response to 2-benzoxasolinone (BOA)
CC exposure (PubMed:25727347). Expression is also induced in response to
CC 6-methoxy-2-benzoxazolinone (MBOA) and 2-aminophenol (2-AP) treatment
CC (PubMed:26828593). {ECO:0000269|PubMed:25727347,
CC ECO:0000269|PubMed:26828593}.
CC -!- DISRUPTION PHENOTYPE: Shows significantly reduced growth but does not
CC affect tolerance to benzoxazolinone. {ECO:0000269|PubMed:26828593}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000305}.
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DR EMBL; AFNW01000283; EKJ71681.1; -; Genomic_DNA.
DR RefSeq; XP_009259520.1; XM_009261245.1.
DR EnsemblFungi; EKJ71681; EKJ71681; FPSE_08127.
DR GeneID; 20366745; -.
DR KEGG; fpu:FPSE_08127; -.
DR eggNOG; ENOG502SHQ6; Eukaryota.
DR HOGENOM; CLU_027816_3_1_1; -.
DR InParanoid; K3UII4; -.
DR Proteomes; UP000007978; Chromosome 2.
DR Proteomes; UP000007978; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR013057; AA_transpt_TM.
DR Pfam; PF01490; Aa_trans; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..476
FT /note="Transmembrane transporter FPSE_08127"
FT /id="PRO_0000454607"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 476 AA; 51198 MW; 61C1362FE5B6295A CRC64;
MASPTASSIL QYSGTGQKEK GTLDHGDVPS VDIGKGETKE VFQENVDGVE FRTVSWQRAT
VVFLKINFAM SILAIPAALG ALGSIGGSLC IIGYTSLNVY TGLILGDIKH NHTECHTLAD
MMGLIWGRWG RELVGVQIII AQTLVTAGGV VAITIGFNAL SDHGTCTVAF GLISAIAVTA
FSAIRTFSKL GWLTWIGFIT FVIGVFIFVV AVTQVDRPAA APQTGDFDLG WAPIAYPSFV
VGMVSVTNIF ISTCGSSNFI PVISEMKRPQ DYRKACLVAG FIVGAMYLSF SLVIYRYCGV
WLSTPAFASA GPIVKKVAYG VSLPGLILGV GIYQHVAAKY AFVRVLRDSK HLQANTFTHW
GTWLGINIAL GTAAFIVAEA VPILNYLLGL AGAICLAPFS LIFPALLWMH EFKKYKTGTT
TQKVKYSFHV LIMMFGFFMM IAGFYSVVVL IKEAFDTGTI AKVFDCADNS GFVQGK
