FDB3_GIBM7
ID FDB3_GIBM7 Reviewed; 748 AA.
AC W7N466; B6S1X9; W7MTI9; W7N2Q0;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Transcription factor FBD3 {ECO:0000303|PubMed:19302487};
DE AltName: Full=Fusarium detoxification of benzoxazolinone cluster 2 protein 3 {ECO:0000303|PubMed:19302487};
DE Short=FDB2 cluster protein 3 {ECO:0000303|PubMed:19302487};
GN Name=FDB3 {ECO:0000303|PubMed:19302487}; ORFNames=FVEG_12635;
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19302487; DOI=10.1111/j.1365-2672.2009.04246.x;
RA Glenn A.E., Bacon C.W.;
RT "FDB2 encodes a member of the arylamine N-acetyltransferase family and is
RT necessary for biotransformation of benzoxazolinones by Fusarium
RT verticillioides.";
RL J. Appl. Microbiol. 107:657-671(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP FUNCTION.
RX PubMed=11876429; DOI=10.1094/mpmi.2002.15.2.91;
RA Glenn A.E., Gold S.E., Bacon C.W.;
RT "Fdb1 and Fdb2, Fusarium verticillioides loci necessary for detoxification
RT of preformed antimicrobials from corn.";
RL Mol. Plant Microbe Interact. 15:91-101(2002).
RN [4]
RP FUNCTION.
RX PubMed=26808652; DOI=10.1371/journal.pone.0147486;
RA Glenn A.E., Davis C.B., Gao M., Gold S.E., Mitchell T.R., Proctor R.H.,
RA Stewart J.E., Snook M.E.;
RT "Two horizontally transferred xenobiotic resistance gene clusters
RT associated with detoxification of benzoxazolinones by Fusarium species.";
RL PLoS ONE 11:e0147486-e0147486(2016).
CC -!- FUNCTION: Transcription factor; part of the Fusarium detoxification of
CC benzoxazolinone cluster 2 (FDB2) involved in the degradation of
CC benzoxazolinones produced by the host plant (PubMed:19302487,
CC PubMed:26808652). Maize, wheat, and rye produce the 2 benzoxazinone
CC phytoanticipins 2,4-dihy-droxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA)
CC and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA) that, due to their
CC inherent instability once released, spontaneously degrade to the more
CC stable corresponding benzoxazolinones, 6-methoxy-2-benzoxazolinone
CC (MBOA) and 2-benzoxazolinone (BOA), respectively (PubMed:11876429).
CC FDB3 is not essentiel, but contributes to efficient BOA
CC biotransformation (PubMed:19302487). {ECO:0000269|PubMed:11876429,
CC ECO:0000269|PubMed:19302487, ECO:0000269|PubMed:26808652}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- INDUCTION: Expression is induced in response to 2-benzoxasolinone (BOA)
CC exposure. {ECO:0000269|PubMed:26808652}.
CC -!- DISRUPTION PHENOTYPE: Decreases, but does not eliminate the ability to
CC metabolize 2-benzoxasolinone (BOA). {ECO:0000269|PubMed:19302487}.
CC -!- MISCELLANEOUS: Fusarium verticillioides possesses 2 unlinked loci, FDB1
CC and FDB2, necessary for detoxification of antimicrobial compounds
CC produced by maize, including 2-benzoxazolinone (BOA) (Probable). The
CC FDB2 cluster arose as a duplication of the FDB1 cluster with
CC rearrangement and expansion by incorporating additional genes
CC (Probable). {ECO:0000305|PubMed:26808652}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACE00535.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EWG54415.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EWG54416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; EU567121; ACE00535.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DS022261; EWG54414.1; -; Genomic_DNA.
DR EMBL; DS022261; EWG54415.1; ALT_SEQ; Genomic_DNA.
DR EMBL; DS022261; EWG54416.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_018760605.1; XM_018901983.1.
DR RefSeq; XP_018760606.1; XM_018901984.1.
DR RefSeq; XP_018760607.1; XM_018901985.1.
DR GeneID; 30070063; -.
DR KEGG; fvr:FVEG_12635; -.
DR VEuPathDB; FungiDB:FVEG_12635; -.
DR eggNOG; ENOG502RD0D; Eukaryota.
DR OrthoDB; 1285920at2759; -.
DR Proteomes; UP000009096; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..748
FT /note="Transcription factor FBD3"
FT /id="PRO_0000454603"
FT DNA_BIND 32..59
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 82410 MW; 373249F9CCD7F632 CRC64;
MPEQPRRPSD QEQNQSETGP PTNKRRRIGL ACNACRSRKS RCDGQRPSCS SCLSLGFDCM
YEPGDSATNV IVRKDYVTDL EQRVSSVEHN LQRLNDVLKG HLSPCTNANT SPCHHGTINA
GPSMPSPAPT APTKASAPSG ARTGTCATSL EEPQDEEGIP NGMAMTFVEE KTSAFYGEAS
NINFTQLLLR AIAVAHDSPG APSGLDRASV LGESVVASVS QSKSSLGGTA TPFDSLPTAL
PSVEEMDTLL DLYFDTAGVV FPFIHEETMR KTYNECRLNG FTRARRTWLG TLNMVFAMAS
NFDRDYTTSS KKRFERSNIF YKRAMGLCNE LSKRVISLEI VHYLILVVLH CQGTSRSVQA
WNNYGLVIRS AMALGLHAES TERALNPVQK EYRRRTWVVI YCLDKVLSTA VGRPASIPDE
QMMRREPSSG RSPATSGNAA DLPGDFLAVS FRMYQVMSKS LVIQYGANLD HDSELDEMAH
LKASGELRKQ LRLWAANLPP HLQLCDVESD VLLQNTKANR LRVILTMRYH NLSILIHKPL
LSATILHLFR QGDAANDASS YLIQLAMAEA HECIRSAQLT IDIVHSVITV DATSKNNLGV
WYFTLYYVFT ASLVICGRLL WAQHGDTVVD EASASHMRFL LGKAETIFLN LDHENSLVLS
CLEYVRRLSR MCGIRETGPD AASASIHDNG SNSTGSADAM SFDLDNMDPF QLFASEMFDP
AIFDHFNQSP VDGMSFVNGL WDGFPCGG
